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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Mesenchymal stem cells :clinical applications and biological characteriation显示文摘 | Frank PB Murphy JM | 2004 | Intern J Biochem Cell Biol2004，36，： | 1 |
| 3 | Advanced glycation end products and the kidney 显示文摘 | Bohlender JM Franke S Stein G | 2005 | Am J Physiol Renal Physiol2005，289，4： | 1 |
| 4 | The efficacy of magnetic resonance imaging in pediatric cervical spine clearance显示文摘 | Frank JB Lim CK Flynn JM | 2002 | Spine2002，27，11： | 1 |
| 5 | Tachycardia-mediated cardiomy opathy and the permanent form of junctional reciprocating tachycardia显示文摘 | Bensler JM Frank CM Razavi M | 2010 | Tex Heart Inst J2010，37，6： | 1 |
| 6 | Serum anti-müllerian hormone levels best re?ect the reproductive decline with age in normal women with proven fertility: a longitudinal study显示文摘 | Rooij IA Frank JM Scbeffe GJ | 2005 | Fertil Steril2005，83，4： | 1 |
| 7 | Stresses and satisfactions of family caregivers to older stroke patients显示文摘 | Kinney JM Stephens MA Frank MM | 1995 | The Journal of Applied Gerontology1995，14，1： | 1 |
| 8 | Temperature monito- ring practices during regional anesthesia 显示文摘 | Frank SM Nguyen JM Garcia CM | 1999 | Anesth Analg1999，88，2： | 1 |
| 9 | Revascularization during acute myocardial infarction:risks and benefits revisited 显示文摘 | Albes JM Gross M Franke U | 2002 | Ann Thorac Surg2002，74，1： | 1 |
| 10 | Advanced glycation end products and the kidney显示文摘 | Bohlender JM Franke S Stein G | 2005 | Am J Physiol Renal Phys- iol2005，289，4： | 1 |
| 11 | Cloning of wound-induced cytochrome P450 monooxygenases expressed in pea 显示文摘 | Frank MR Deyneka JM Schuler MA | 1996 | Plant Physiol1996，110，3： | 1 |
| 12 | Five-year outcome for maintenance therapies in recurrent depression 显示文摘 | Kupfer DJ Frank E Perel JM | 1992 | Arch Gen Psychiatry1992，49，10： | 1 |
| 13 | Short echo time projection reconstruction MR imaging of cartilage :camparsion with fatsuppressed spoiled GRASS and magnetization transfer contrast MR imaging显示文摘 | Rossmann J Frank LR Pauly JM | 1997 | Radiology1997，203，2： | 1 |
| 14 | Sudden gains in interpersonal psychotherapy for depression 显示文摘 | Kelly MA Cyranowski JM Frank E | 2007 | Behav Res Ther2007，45，11： | 1 |
| 15 | Three - year outcomes for maintenance therapies in recurrent depression显示文摘 | Frank E Kupfer D J Perel JM | 1990 | Arch Gen Psy- chiatry1990，47，12： | 1 |
| 16 | Predictors of poor o-varian response in invitro fertilization: a prospective study comparing basal markers of ovarian reserve 显示文摘 | Bancsi Frank JM Brroekmans | 2002 | Fertil Steril2002，77，2： | 1 |
| 17 | Five-year outcome for main- tenance therapies in recurrent depression显示文摘 | Kupfer D J Frank E Perel JM | 1992 | Arch Gen Psychia- try1992，49，10： | 1 |
| 18 | Suboccipital decompression tor Chiari I malformation :outcome comparison of duraplasty with expanded polytetrafluoroethylene dural substitute versus pericrmlial autograft 显示文摘 | Frank JA Matthew JM Giannina LG-A | 2009 | Child''s Nervous System2009，25，： | 1 |
| 19 | The effect of R-40244 on male reproductive function in the rabiit and nonhuman prime显示文摘 | Wilczynski SL Killinger JM Frank DW | 1986 | J Adrol1986，7，2： | 1 |
| 20 | Relationship of pharmaco- logic compliance to long-term prophylaxis in recurrent depression 显示文摘 | Frank E Perel JM Mallinger AG | 1992 | Psychopharmacol Bulletin1992，28，3： | 1 |
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