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| 1 | 轿车变速器的表面致密化粉末冶金齿轮的使用性能显示文摘选择性表面致密化是改进粉末冶金钢的一种方法,高负载齿轮经过这种加工工艺处理,就能达到使用要求。本文介绍了粉末冶金螺旋齿轮的制造工艺与性能,用三轴总成成对试验台架、承载能力试验台架及噪声试验台架测定了齿轮的使用性能,并把试验结果和具有同样几何形状与表面质量的锻钢齿轮的数据进行了比较。结果表明,粉末冶金齿轮的承载能力与噪声级可和锻钢齿轮相媲美。 | Cünter Rau Lorenz S Sigl Gerold Mrk Frank Wattenberg 韩凤麟 | 2012 | 粉末冶金技术2012，30，4： | 2 |
| 2 | Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobinuria显示文摘 | Moore JG Humphries RK Frank MM | 1986 | Exp Hematol1986，14，： | 1 |
| 3 | The antral follicle count is a better marker than basal follicle-stimulating hormone for the selection of older patients with acceptable pregnancy prospects after in vitro fertilization显示文摘 | Ellen RK Frank JMB Caspar WNL | 2005 | Fertil Steril2005，83，3： | 1 |
| 4 | Animation of the dynamical events of the elongation cycle based on cryoelectron microscopy of functional complexes of the ribosome显示文摘 | Heagle AB Agrawal RK | 1999 | J Struct Biol1999，128，： | 1 |
| 5 | A ratchet-like inter-subunit reorganization of the ribosome during translocation显示文摘 | Agrawal RK | 2000 | Nature2000，406，： | 1 |
| 6 | Genotype - phenotype relationship in multiple endocrine neoplasiatype 2, implications for clinical management 显示文摘 | Raue F Frank RK | 2009 | Hormones(Athens)2009，8，1： | 1 |
| 7 | Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobin- uria显示文摘 | Moore JG Humphries RK Frank MM | 1986 | Exp Hematol1986，14，3： | 1 |
| 8 | Postharvest seed maturation of American ginseng: stratification temperatures and delay ofstratification显示文摘 | Jaeseong J Frank AB Thomas RK | 1988 | Hort Science1988，23，： | 1 |
| 9 | Local ization of L11 protein on the ribosome and elucidation of its in volvement in EF-G-dependent translocation 显示文摘 | Agrawal RK Linde J Sengupta J Nierhaus KH Frank J | 2001 | J Mol Biol2001，311，4： | 1 |
| 10 | Novel Isatin-Schiff Base Cu (II) and Ni(II) Complexes. X-ray Crystal Structure of Bis[3-(4-hexylphenylimino)-1H-indol-2(3H)-one]-dichlorocopper(II) Complex显示文摘Schiff base ligand (HL) derived from 4-hexylaniline with isatin (1H-indole-2,3-dione)and its complexes with Cu(II), Ni(II) were prepared and characterized by analytical, spectroscopic(IR, UV-Vis, Mass) techniques, electrical conductivity, magnetic and thermal measurements. Thecrystal and molecular structure of [Cu(HL)2Cl2] was determined by a single-crystal X-raydiffraction study. The molecular structure of the title compound has an inversion center on theCu atom. | Ayse ERCAG Sema Oztürk YILDIRIM Mehmet AKKURT Mahmure Ustün OZGUR Frank W. HEINEMANN | 2006 | Chinese Chemical Letters2006，17，2： | 0 |
| 11 | finDr:A web server for in silico D-peptide ligand identification显示文摘In the rapidly expanding field of peptide therapeutics,the short in vivo half-life of peptides represents a considerable limitation for drug action.D-peptides,consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids(AAs),do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation,resulting in a favourable pharmacokinetic profile.To experimentally identify D-peptide binders to interesting therapeutic targets,so-called mirror-image phage display is typically performed,whereby the target is synthesized in D-form and L-peptide binders are screened as in conventional phage display.This technique is extremely powerful,but it requires the synthesis of the target in D-form,which is challenging for large proteins.Here we present finDr,a novel web server for the computational identification and optimization of D-peptide ligands to any protein structure(https://findr.biologie.uni-freiburg.de/).finDr performs molecular docking to virtually screen a library of helical 12-mer peptides extracted from the RCSB Protein Data Bank(PDB)for their ability to bind to the target.In a separate,heuristic approach to search the chemical space of 12-mer peptides,finDr executes a customizable evolutionary algorithm(EA)for the de novo identification or optimization of D-peptide ligands.As a proof of principle,we demonstrate the validity of our approach to predict optimal binders to the pharmacologically relevant target phenol soluble modulin alpha 3(PSMα3),a toxin of methicillin-resistant Staphylococcus aureus(MRSA).We validate the predictions using in vitro binding assays,supporting the success of this approach.Compared to conventional methods,finDr provides a low cost and easy-to-use alternative for the identification of D-peptide ligands against protein targets of choice without size limitation.We believe finDr will facilitate D-peptide discovery with implications in biotechnology and biomedicine. | Helena Engel Felix Guischard Fabian Krause Janina Nandy Paulina Kaas Nico Hofflin Maja Kohn Normann Kilb Karsten Voigt Steffen Wolf Tahira Aslan Fabian Baezner Salom´e Hahne Carolin Ruckes Joshua Weygant Alisa Zinina Emir Bora Akmeriç Enoch B.Antwi Dennis Dombrovskij Philipp Franke Klara L.Lesch Niklas Vesper Daniel Weis Nicole Gensch Barbara Di Ventura Mehmet Ali Oztürk | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 0 |
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