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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Mining and characterizing microsatellites from citrus ESTs显示文摘 | Chunxian Chen Ping Zhou Young A Choi Shu Huang Fred G. Gmitter | 2006 | Theoretical and Applied Genetics2006，，7： | 3 |
| 3 | An approximate analytical method for solving strong coupling Schr?dinger equation显示文摘 | Hibbert A Jonsson P | 1987 | Phys Rew D1987，36，： | 1 |
| 4 | Combining multipleclustering using ev- idence accumulation 显示文摘 | FRED A ANAL N | 2005 | IEEE Transactions on Pattern A- nalysis and Machine Intelligence2005，27，6： | 1 |
| 5 | Gelation of casein-whey protein mixtures显示文摘 | VASBINDER A J FRED V D V | 2004 | J Dairy Sci2004，87，： | 1 |
| 6 | Dynamic gas slippage: a unique equal mechanism approach to the flow gas slippage in tight formation显示文摘 | Turgay Eetekin Gregory A King Fred C Schwerer | 1986 | SPE Formation Evaluation1986，1，1： | 1 |
| 7 | Mining and characterizing microsatellites from citrus ESTs显示文摘 | CHEN C X ZHOU P CHOI Y A HUANG S FRED G GMITTER J | 2006 | Theor Appl Genet2006，112，： | 1 |
| 8 | Combining Multiple Clusterings Using Evidence Accumulation显示文摘 | Fred A L N Jain A K | | 0，，6： | 1 |
| 9 | A novel thermostable nitrile hydratase 显示文摘 | Rui A Dan G Fred A | 1998 | Extremophiles1998，2，2： | 1 |
| 10 | Balanced scorecard, activity-based costing and company performance: An empirical analysis 显示文摘 | ADAM S M FRED A J | 2003 | Journal of Managerial Issues2003，15，3： | 1 |
| 11 | Comparison of airborne hyperspectral data and EO-1 hyperion for mineral mapping 显示文摘 | Fred A Kruse Joseph W Boardman Jonathan F Huntington | 2003 | IEEE2003，41，6： | 1 |
| 12 | Distinguishing hope and optimism:two sides of a coin,or two separate coin显示文摘 | Fred B B Jamie A C | 2004 | Joumal of Social and Clinical Psychology2004，，： | 1 |
| 13 | SCTP What,Why and How显示文摘 | Preethi N Fred B Paul D A | 2009 | IEEE IntemetComputing2009，13，5： | 1 |
| 14 | Early detection of lung cancer:clinical perspectives of recent advances in biology and radiology 显示文摘 | Fred R Hirsch Wibur A | 2001 | Clin Cancer Res2001，7，1： | 1 |
| 15 | The role of orientation flights on homing performance in honeybees 显示文摘 | Elizabeth A Capaldi Fred C Dyer | 1999 | Experimental Biology1999，202，： | 1 |
| 16 | Child maltreatment and emergent person-ality or-ganization:perspectives from the five-factor model 显示文摘 | Fred A Dante C | 2004 | Journal of Abnormal Child Psychology2004，32，2： | 1 |
| 17 | In search of the essence of a good teacher:towards a more holistic approach in teacher education显示文摘 | KORTHAGEN FRED A J | 2004 | Teaching and Teacher Education2004，20，1： | 1 |
| 18 | Mechanical properties of the posterolateral structures of the knee显示文摘 | Robert F Laprade Timothy S Bollom Fred A Wentorf | | 0，，： | 1 |
| 19 | Catalysis of the electroreduetion of O2 by cobalt 5,10,15,20-tetra-phenylporphyrin dissolved in Thin Layers of Benzonitrile Oil Graphite Electrodes显示文摘 | Fred C A | 2001 | J Electroanai Chem2001，508，： | 1 |
| 20 | Meta-Analysis of the Impact of Positive Psychological Capital on Employee Atti- tudes, Behaviors, and Performance显示文摘 | James B A Rebecca J R Fred L Ketan H M | 2011 | Human Resource Develop- ment Quarterly2011，，2： | 1 |
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