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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | 气候变化和紫外线辐射对北极淡水鱼类及溯河产卵鱼类渔业的影响显示文摘北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引导北极未来的渔业走向可持续性。当务之急是为商业渔业选择灵活和快速反应的'适宜管理'方式;改变生计渔业的当地土地和资源利用模式;改变很多休闲渔业的特性、管理方式和地点。总的来说,在气候变化及其对北极淡水水域和生物区影响的复杂性和不确定性情况下,为保证生态系统和主导鱼种有足够的恢复力和应对将来变化的能力,需要对渔业的各个方面实施更保守的管理办法。 | James D.Reist Frederick J.Wrona Terry D.Prowse J.Brian Dempson Michael Power Günter Kck Theresa J.Carmichael Chantelle D.Sawatzky Hannu Lehtonen Ross F.Tallman 曾首英 | 2006 | AMBIO-人类环境杂志2006，35，7： | 4 |
| 3 | Quantitative aspects of reversible osmotic opening of the blood-brain barrier显示文摘 | Rapoport S I Fredericks W R Ohno K | 1980 | Am J Physiol1980，238，5： | 2 |
| 4 | Pbarmackinelics and bioavailability of the isoflavone hiochanin A in rats显示文摘 | Moon YJ Sagawa K Frederick K | 2006 | AAPS J2006，8，3： | 1 |
| 5 | Optimal Path Planning for UCAV to Defeat Radar Tracking 显示文摘 | Pierre T K Semyou M M Frederick H Z | 2006 | Journal of Guidance Control and Dynamics March-April2006，29，2： | 1 |
| 6 | Risk Factors for hepatic morbidity following nonoperative management显示文摘 | Rosemary A K Frederick A M Clay C | 2006 | Archives of Surgery2006，141，5： | 1 |
| 7 | Finite element analysis of steel girder highway bridges 显示文摘 | Mabsout M E Tarhini K M Frederick G R Tayar C | 2002 | Journal of bridge Engineering2002，7，5： | 1 |
| 8 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-- Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percu- taneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) : A Report of the American College of Cardi- ology Foundation/American Heart Association Task Force on Prac- tice Guidelines显示文摘 | Frederick G K Mary H Sidney C S | 2009 | JACC2009，54，23： | 1 |
| 9 | Prevalence and associa tions of 25-hydroxyvitamin D deficiency in US children NHANES 2001- 2004 显示文摘 | Juhi K Paul M Frederick JK | 2009 | Pediatrics2009，124，3： | 1 |
| 10 | Life threat and posttraumatic stress in school -age children显示文摘 | Pynoos RS Frederick C Nader K | 1987 | Archiees of General Psychiatry1987，44，12： | 1 |
| 11 | A Randomized Controlled Trial to Deter mine the Effect of Depth of Anesthesia on Emergence Agitation in Children 显示文摘 | Frederick HJ Wofford K De LDG | 2016 | Anesth Analg2016，122，4： | 1 |
| 12 | Wheel load distribution in I-girder highway bridges显示文摘 | Tarhini K M Frederick G R | 1992 | ASCE Journal of Structural Engineering1992，118，5： | 1 |
| 13 | 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission显示文摘 | Pagel John M Appelbaum K Frederick R | 2006 | Blood2006，107，5： | 1 |
| 14 | Changing practice patterns for children with heart disease: a clinical pathway apprcach显示文摘 | Uzark K Frederick C Lamberti JJ | 1998 | Am J crit care1998，7，： | 1 |
| 15 | Benefit of transferring ST segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase显示文摘 | Pinto D S Frederick P D Chakrabarti A K | 2011 | Circulation2011，124，23： | 1 |
| 16 | Orien- ted silicon carbide nanowires: Synthesis and field emis- sion properties 显示文摘 | PAN Z W LAI H L FREDERICK C K | 2000 | Adv Mater2000，12，16： | 1 |
| 17 | Changing practice patterns for children with heart disease : a clinicalpathway approach显示文摘 | UZARK K FREDERICK C LAMBERTI JJ | 1998 | Am J Crit Care1998，7，2： | 1 |
| 18 | Increasing socioeconomic disparities in adolescent obesity 显示文摘 | Frederick CB Snellman K Putnam RD | 2014 | Proc Natl Acad Sci USA2014，111，4： | 1 |
| 19 | Effect of sorghum flour composition and particle size on quality properties of gluten-free bread显示文摘 | Emily Frederick T Hanna K Fadi A | 2015 | Food Science&Technology International2015，21，3： | 1 |
| 20 | Changing Practice Patterns for Childrens with Heart Disease a Clinical Pathway Apprcath显示文摘 | Uzark K Frederick C Lamberti J J | 1998 | Am J Crit1998，7，12： | 1 |
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