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| 1 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | The safety of dedicated-team catheter-based diagnostic cerebral angiography in the era of advanced noninvasive imaging显示文摘 | Thiex R Norbash AM Frerichs KU | | 0，，2： | 1 |
| 4 | Fibrin sealing and histometrical changes in conventionally sutured microvascular anastomoses显示文摘 | Bschorer R Frerich B Wolburg H | 1993 | J Craniomaxillofic Surg1993，21，5： | 1 |
| 5 | Optical sensor systems for bioprocess monitoring显示文摘 | Ulber R Frerichs J G Beutel S | 2003 | Anal Bioanal Chem2003，376，： | 1 |
| 6 | 显示文摘 | CHI K M FRERICHS S R STEIN B K | 1988 | J Am Chem Soc1988，110，： | 1 |
| 7 | Five-year fllow-up of cognitive impairment with no dementia显示文摘 | Tuokko H Frerichs R Craham J | 2003 | Arch Nearol2003，60，4： | 1 |
| 8 | Five - year follow - up of cog-nitive impairment with no dementia 显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neurol2003，60，4： | 1 |
| 9 | Ulcerativerhabdovirus in fish in South-East Asia 显示文摘 | Frerichs G N Millar S D Roberts R J | 1986 | Nature1986，322，6076： | 1 |
| 10 | Sim ultaneous determination of eortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, my- cophenolicacid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tan- dem mass spectrometry显示文摘 | Difranceseo R Frerichs V Donnelly J | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，859，1： | 1 |
| 11 | Simultaneous determination of cortisol,dexamethasone,methyl-prednisolone,prednisone,prednisolone,myeophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tandem mass spectrometry显示文摘 | Difrancesco R Frerichs V Donnelly J | | 0，，： | 1 |
| 12 | Five-year follow-up of Cognitive Impairment with no dementia显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neurol2003，60，4： | 1 |
| 13 | Five-year follow-up of cognitive impairment with no dementia显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neurol2003，60，4： | 1 |
| 14 | The safety of dedicated-team catheter-based diagnostic cerebral angiography in the era of advanced noninvasive imaging显示文摘 | Thiex R Norbash AM Frerichs KU | 2009 | AJNR Am J Neuroradiol2009，2009，： | 1 |
| 15 | Cadmium Sulfide X-Ray Detector显示文摘 | Frerichs R | 1959 | J Appl Phys1959，30，： | 1 |
| 16 | Dissemination of hepatocellular carcinoma ismediated via chemokine receptor CXCR4显示文摘 | Schimanski C C Bahre R Gockel I Müller A Frerichs K Hrner V | 2006 | Br J Cancer2006，95，： | 1 |
| 17 | Five-year follow- up of cognitive impairment with no dementia显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neural2003，60，4： | 1 |
| 18 | Five-year follow-up of cognitive impairment with no dementia显示文摘 | Tuokko H Frerichs R Graham J | | 0，，04： | 1 |
| 19 | Five-year follow-up of cognitive impaimmnt with no dementia显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neurol2003，60，4： | 1 |
| 20 | Five-year follow-up of cognitive impairment with no dementia显示文摘 | Tuokko H Frerichs R Graham J | 2003 | Arch Neurol2003，60，4： | 1 |
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