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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | Two pathways for base excision repair in mammalian cells显示文摘 | Frosina G Fortini P Rossi O | 1996 | J Biol Chem1996，271，16： | 1 |
| 3 | Intraepithelial CDS+ tumor-infiltrating lymphocytes and a high CD8+/regnlatory T cell ratio are associated with favorable prognosis in ovarian cancer显示文摘 | Sato E Olson SH Ahn J Bundy B Nishikawa H Qian F Jungbluth AA Frosina D Gnjatic S Ambrosone C Kepner J Odunsi T Ritter G Lele S Chen YT Ohtani H Old LJ Odunsi K | 2005 | Proc Natl Acad Sci USA2005，102，18： | 1 |
| 4 | The bright and the dark sides of DNA repair in stem cells显示文摘 | Frosina G | 2010 | J Biomed Biotechnol2010，2010，84： | 1 |
| 5 | Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes显示文摘 | Frosina G | 2001 | Carcinogenesis2001，22，9： | 1 |
| 6 | Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes显示文摘 | Guido Frosina | 2001 | Carcinogenesis2001，22，9： | 1 |
| 7 | DNA Repair and Resistance of Gliomas to chemotherapy and Radiotherapy 显示文摘 | Guido Frosina | 2009 | Mol Cancer Res2009，7，： | 1 |
| 8 | Stem cell-mediated delivery of therapies in the treatment of glioma显示文摘 | Frosina G | 2011 | Mini Rev Med Chem2011，11，7： | 1 |
| 9 | Counteracting spontaneous transformation via overexpression of rate limitingDNA base excision repair enzymes 显示文摘 | Guido Frosina | 2001 | Carcinogenesis2001，22，9： | 1 |
| 10 | Frontiers in targeting glioma stem cells 显示文摘 | Frosina G | 2011 | Eur J Canc-er2011，47，4： | 1 |
| 11 | Involvement of XRCCl and DNA ligase III gene products in DNA base excision repair显示文摘 | CAPPELLI E TAYLOR R CEVASCO M ABBONDANDOLO A CALDECOTT K FROSINA G | 1997 | J Biol Chem1997，272，23： | 1 |
| 12 | Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes显示文摘 | Cubeddu TL Frosina G | 1985 | Diabetologia1985，28，9： | 1 |
| 13 | Frontiers in targeting glioma stem cells 显示文摘 | Frosina G | 2011 | Eur J Cancer2011，47，4： | 1 |
| 14 | Stem Cell-Mediated Delivery of Therapies in the Treat- ment of Glioma 显示文摘 | Frosina G | 2011 | Mini-Reviews in Medicinal Chemistry2011，11，7： | 1 |
| 15 | Gene prophylaxis by a DNA repair function显示文摘 | FROSINA G | 2007 | Mol Aspects Med2007，28，34： | 1 |
| 16 | DNA repair and resistance of gliomas to chemotherapy and radiotherapy显示文摘 | Frosina G | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 17 | Contrast-enhanced ultrasound appearances of enhancement patterns of intrahepatic cholangiocarcinoma: correlation with pathological findings显示文摘 | Francesco Loria Giuseppe Loria Salvatore Basile Giuseppe Crea Luciano Frosina Isidoro Di Carlo | 2014 | Updates in Surgery2014，，2： | 1 |
| 18 | DNA repair and resistance of gliomas to chemotherapy and radiotherapy显示文摘 | Frosina G | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 19 | Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes 显示文摘 | Frosina G | 2001 | Carcinogenesis2001，22，9： | 1 |
| 20 | Role of contrast-enhanced ultrasound in the evaluation of vascularization of hepatocellular carcinoma显示文摘Aim:Early individualization of hepatocellular carcinoma is crucial to obtain good therapeutic results,thanks to several options such as percutaneous therapies,surgical resections and transplant.Aim of this study is to evaluate the vascularization of hepatocarcinoma using contrast enhanced ultrasound(CEUS)in comparison with multislice computed thomography(MSCT).Methods:Between January 2009 and May 2014,67 patients affected by hepatocarcinoma,who presented an overall of 92 nodules,were examined and enrolled in the study.Results:There was a significant difference in the percentage of comparison of the vascularization between the nodules situated at a depth not greater than 9 cm,compared to those studied at a greater depth.In reference to the size of the lesion,the percentage of vascularization to the CEUS in arterial phase,compared with the MSCT,was 84%in lesions with dimensions equal or less than 1 cm,91%in lesions with dimensions included between 1 and 2 cm,and 96%in the lesions greater than 2 cm.Conclusion:CEUS is a method capable of documenting with very reliable accuracy the intralesional vascularization of hepatic carcinoma,in a superimposable manner to the MSCT.However,CEUS also presents some limitations,mainly in relation to the site of lesions. | Francesco Loria Giuseppe Loria Salvatore Basile Giuseppe Crea Luciano Frosina Francesca Frosina | 2016 | Hepatoma Research2016，2，1： | 1 |
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