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| 1 | Non-invasive assessment of barrier integrity and function of the human gut显示文摘Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function. | Joep Grootjans Geertje Thuijls Froukje Verdam Joep PM Derikx Kaatje Lenaerts Wim A Buurman | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 18 |
| 2 | Coronary pressure-flow relations as basis for the understanding of coronary physiology显示文摘 | Tim P. van de Hoef Froukje Nolte M. Cristina Rolandi Jan J. Piek Jeroen P.H.M. van den Wijngaard Jos A.E. Spaan Maria Siebes | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 1 |
| 3 | Improved oxygenation in patient with acute respiratory failure:the prone position显示文摘 | Douglas WW Rehder K Froukje MB | 1977 | American Review of Respiratory Disease1977，115，： | 1 |
| 4 | Environmental risk assessment for the polycyclic musks AHTN and HHCB in the EU显示文摘 | Froukje Balk Richard A. Ford | 1999 | Toxicology Letters1999，，1： | 1 |
| 5 | Long-term results of stomach-conserving therapy in gastric MALT lymphoma显示文摘 | Conny Vrieling Daphne de Jong Henk Boot Jan Paul de Boer Froukje Wegman Berthe M.P. Aleman | 2008 | Radiotherapy and Oncology2008，，3： | 1 |
| 6 | Bariatfic surgery in morbidly obese adolescents:a systematic review and meta-a- nalysis 显示文摘 | Givan F Paulus Loes EG de Vaan Froukje J Verdam | 2015 | Obesity Surgery2015，25，5： | 1 |
| 7 | Improved oxygenation in patient with acute respiratory failure:The prone position显示文摘 | Douglas WW Rehder K Froukje MB | | 0，，： | 1 |
| 8 | Improved oxygenation in patient with acute respiratory failure:the prone position显示文摘 | DOUGLAS W W REHDER K FROUKJE M B | 1977 | Am Rev Respir Dis1977，115，4： | 1 |
| 9 | Presupplementary Motor Area Hyperactivity During Response Inhibition: A Candidate Endophenotype of Obsessive-Compulsive Disorder显示文摘 | de Wit Stella J de Vries Froukje E van der Werf Ysbrand D Cath Danielle C Heslenfeld Dirk J Veltman Eveline M van Balkom Anton JLM Veltman Dick J van den Heuvel Odile A | 2012 | The American Journal of Psychiatry2012，，10： | 1 |
| 10 | A framework for empathy in design: stepping into and out of the user’s life显示文摘 | Merlijn Kouprie Froukje Sleeswijk Visser | 2009 | Journal of Engineering Design2009，，5： | 1 |
| 11 | Scale dependent effects of grazing and topographic heterogeneity on plant spe- cies richness in a Dutch salt marsh ecosystem显示文摘 | Jasper L R Froukje P Han () Christian S | 2014 | Applied Vegetation Science2014，17，4： | 1 |
| 12 | The Blue Revolution in Asia: Upgrading and Governance in Aquaculture Value Chains 显示文摘 | Ponte Stefano Kelling Ingrid Jespersen Karen Sau Krui- jssen Froukje | 2014 | WOR- LD DEVELOPMENT2014，，64： | 1 |
| 13 | Improved oxygenation in patient with acute respiratory failure: The prone position显示文摘 | Douglas WW Rehder K Froukje MB | 1977 | American Review of Respiratory Disease1977，115，： | 1 |
| 14 | Influence of high versus low intestinal concentration of Gram-negative bacteria and Endotoxin on the susceptibility of murine myelopoiesis in bone marrow and spleen to cytostatic treatment sith Ara-C显示文摘 | Simon Daenen Henk Gores Froukje de Boer | | Leu0，，： | 1 |
| 15 | Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions: Adenosine-Free Assessment of Functional Coronary Lesion Severity显示文摘 | Tim P. van de Hoef Froukje Nolte Peter Damman Ronak Delewi Matthijs Bax Steven A.J. Chamuleau Michiel Voskuil Maria Siebes Jan G.P. Tijssen Jos A.E. Spaan Jan J. Piek Martijn Meuwissen | 2012 | Circulation: Cardiovascular Interventions2012，，： | 1 |
| 16 | 硝酸银诱导的大豆子叶中大豆Kunitz胰蛋白酶抑制剂的研究显示文摘采用二维电泳技术对硝酸银诱导的大豆子叶微粒体膜蛋白进行分离,利用四极杆-飞行时间串联质谱,对仅存在于诱导样品而不存在于对照样品中的蛋白质点进行氨基酸序列测定和分析,以期研究硝酸银处理对大豆子叶微粒体蛋白质的影响。结果显示:硝酸银可以诱导大豆Kunitz胰蛋白酶抑制剂(SKTI)的产生,在诱导处理的子叶中大量存在其成熟形式,也存在其5 kDa小亚基,小亚基含有“GIGTIISSPER”和“FIAEGNPLR”氨基酸序列。该研究结果为SKTI的深入研究提供了实践依据,并为其分离纯化提供了简便途径,从而有利于对其更多性质的进一步研究。 | 乞永艳 刘富海 Arnaud Bovy Jan Corde wener Froukje vander wal | 2007 | 河北农业大学学报2007，30，4： | 0 |
| 17 | 二维电泳技术在大豆子叶微粒体膜结合蛋白研究中的应用显示文摘以硝酸银诱导的大豆子叶为材料,初步探讨了二维电泳技术在分离大豆子叶微粒体膜结合蛋白中的应用,研究了重新水化溶液的组成、加样量、等电聚焦的total voltage hours以及不同pH梯度范围IPG(固相pH梯度)胶条等因素对膜蛋白的溶解和二维电泳图像的影响。结果表明对于70×3×0.5mmIPG胶条,能够溶解较多蛋白质和获得高质量二维电泳图像的优化条件为:由尿素、硫脲、三丁基膦和C7BZO组成的重新水化溶液(TUC7T2)、80μg的加样量和20000vhr的totalvoltage hour。在此优化条件下,与宽范围pH梯度IPG胶条相比,使用窄范围pH梯度胶条可以观察到更多的和质量更好的蛋白质点,结果发现至少有13个点只存在于硝酸银诱导的样品中,而不存在于对照中,其代表的蛋白质的等电点在4.0-8.0。 | 乞永艳 刘富海 Arnaud Bovy Jan Cordewener Froukje Vander Wal | 2007 | 大豆科学2007，26，1： | 0 |
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