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| 1 | Novel nanometer scaffolds regulate the biological behaviors of neural stem cells显示文摘Ideal tissue-engineered scaffold materials regulate proliferation, apoptosis and differentiation of cells seeded on them by regulating gene expression. In this study, aligned and randomly oriented collagen nanofiber scaffolds were prepared using electronic spinning technology. Their diameters and appearance reached the standards of tissue-engineered nanometer scaffolds. The nanofiber scaffolds were characterized by a high swelling ratio, high porosity and good mechanical properties. The proliferation of spinal cord-derived neural stem cells on novel nanofiber scaffolds was obviously enhanced. The proportions of cells in the S and G 2 /M phases noticeably increased. Moreover, the proliferation rate of neural stem cells on the aligned collagen nanofiber scaffolds was high. The expression levels of cyclin D1 and cyclin-dependent kinase 2 were increased. Bcl-2 expression was significantly increased, but Bax and caspase-3 gene expressions were obviously decreased. There was no significant difference in the differentiation of neural stem cells into neurons on aligned and randomly oriented collagen nanofiber scaffolds. These results indicate that novel nanofiber scaffolds could promote the proliferation of spinal cord-derived neural stem cells and inhibit apoptosis without inducing differentiation. Nanofiber scaffolds regulate apoptosis and proliferation in neural stem cells by altering gene expression. | Jihui Zhou Fuge Sui Meng Yao Yansong Wang Yugang Liu Feipeng Tian Qiang Li Xiaofeng He Lin Shao Zhiqiang Liu | 2013 | Neural Regeneration Research2013，8，16： | 2 |
| 2 | A clinical features, risk factors and outcome of thrombotic thrombocytopenic purpura occurring after done marrowtransplantation 显示文摘 | Fuge R Bird JM Fraser A | 2001 | Br J Haematol2001，113，： | 1 |
| 3 | A clinical feature,risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation显示文摘 | Fuge R Bird JM Fraser A | 2001 | Br J Haematol2001，113，： | 1 |
| 4 | Sulfur doping of diamond films:Spectroscopic, electronic, and gas-phase studies 显示文摘 | JAMES R PETHERBRIDGE PAUL W MAY GARETH M FUGE | 2002 | Journal of Applied Physics2002，91，6： | 1 |
| 5 | Synthesis of aligned arrays of ultrathin ZnO nanotubes on a Si wafer coated with a thin ZnO film 显示文摘 | Y Sun GM Fuge NA Fox | 2005 | Advanced Materials2005，17，： | 1 |
| 6 | Evolving kernel principal component analysis for fault diagnosis显示文摘 | SUN Rui-xiang FUGEE T QU Liang-sheng | 2007 | Computers & Induetrial Engineering2007，53，： | 1 |
| 7 | The clinical features,risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation显示文摘 | Fuge R Brid JM Fraser A | 2001 | Br J Haematol2001，113，2： | 1 |
| 8 | On the behaviour of fluorine and chlorine during mag matic differentiation显示文摘 | Fuge R | 1977 | Contributions to Mineralogy and Pe- trology1977，61，3： | 1 |
| 9 | Sources of halogens in the environment,influences on human and animal health显示文摘 | Fuge R | 1988 | Environmental Geochemistry and Health1988，10，2： | 1 |
| 10 | A Mean-shift Pattern Study on Integration of SPC and APC for Process Monitoring显示文摘 | Tsung Fugee Tsui Kwok-leung | 2003 | IIE Trans2003，35，3： | 1 |
| 11 | A study of variable EWMA controller显示文摘 | Sheng-Tsaing Tseng Arthur B Yeh Fugee Tsung | 2003 | IEEE Trans on Semicon Manu2003，16，4： | 1 |
| 12 | A clinical features, risk fhctors and outcome of thrombotic thrombocytopenic purpura occurring ailcr bone marrow transplantation显示文摘 | Fuge R Bird JM Fraser A | 2001 | Br J Haemato12001，113，1： | 1 |
| 13 | The Dynamic T^2 Chart for Monitoring Feedback-controlled Processes显示文摘 | Tsung Fugee Apley Daniel W | 2002 | IIE Trans2002，34，12： | 1 |
| 14 | A clinical feature, risk factors and outcome of thrombotic thombocytopenic purpura occurring after bone marrow transplantation显示文摘 | Fuge R Bird JM Fraser A | 2001 | Br J Haematol2001，113，： | 1 |
| 15 | Synthesis of aligned arrays of ultra-thin ZnO nanotubes on a thin ZnO film-coated Si wafer 显示文摘 | Sun Y Fuge G M Fox N A | 2005 | Adv Mater2005，17，20： | 1 |
| 16 | The geochemistry of iodine — a review显示文摘 | Ronald Fuge Christopher C. Johnson | 1986 | Environmental Geochemistry and Health1986，，2： | 1 |
| 17 | The clinical features,risk factors and outcome of thrombotic thrombocytopenie purpura occurring after bone marrow transplantation显示文摘 | Fuge R Bird JM Fraser A | | 0，，01： | 1 |
| 18 | Geochemistry of Cd in the secondary near abandoned metalliferous mines in Wlaes显示文摘 | Fuge R Pearce F M Pearce N J G | | 0，，： | 1 |
| 19 | The geochemistry of iodine — a review显示文摘 | Ronald Fuge Christopher C. Johnson | 1986 | Environmental Geochemistry and Health1986，，2： | 1 |
| 20 | 显示文摘 | Sun Y Fuge G M | 2006 | Superlattices and Microstructures2006，39，： | 1 |
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