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| 1 | DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus显示文摘Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric cancer.In particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric carcinogenesis.The etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(H.pylori)and Epstein-Barr virus(EBV),are known to participate in gastric carcinogenesis.Chronic inflammation of the gastric epithelium due to H.pylori infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric cancer.In addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target genes.Here,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with H.pylori and EBV. | Keisuke Matsusaka Sayaka Funata Masashi Fukayama Atsushi Kaneda | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 2 | Hybrid Rubisco with Complete Replacement of Rice Rubisco Small Subunits by Sorghum Counterparts Confers C4 Plant-like High Catalytic Activity显示文摘Photosynthetic rate at the present atmospheric condition is limited by the CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)because of its extremely low catalytic rate(kcat)and poor affinity for C02(Kc)and specificity for CO2(Sc/O).Rubisco in C4 plants generally shows higher k cat than that in C3 plants.Rubisco consists of eight large subunits and eight small subunits(RbcS).Previously,the chimeric incorporation of sorghum C4-type RbcS significantly increased the k cat of Rubisco in a C3 plant,rice.In this study,we knocked out rice RbcS multigene family using the CRISPR-Cas9 technology and completely replaced rice RbcS with sorghum RbcS in rice Rubisco.Obtained hybrid Rubisco showed almost C4 plant-like catalytic properties,i.e.,higher kcai,higher Kc,and lower Sc/O.Transgenic lines expressing the hybrid Rubisco accumulated reduced levels of Rubisco,whereas they showed slightly but significantly higher photosynthetic capacity and similar biomass production under high C 02 condition compared with wild-type rice.High-resolution crystal structural analysis of the wild-type Rubisco and hybrid Rubisco revealed the structural differences around the central pore of Rubisco and the pC-pD hairpin in RbcS.We propose that such differences,particularly in the pC-pD hairpin,may impact the flexibility of Rubisco catalytic site and change its catalytic properties. | Hiroyoshi Matsumura Keita Shiomi Akito Yamamoto Yuri Taketani Noriyuki Kobayashi Takuya Yoshizawa Shun-ichi Tanaka Hiroki Yoshikawa Masaki Endo Hiroshi Fukayama | 2020 | Molecular Plant2020，13，11： | 8 |
| 3 | HER-2阳性胃癌对曲妥珠单抗为基础化疗的病理反应显示文摘以曲妥珠单抗为基础的化疗是目前治疗HER-2阳性晚期胃癌的标准方法,能有效延长晚期HER-2阳性胃癌患者总生存期和无进展生存率。由于手术标本较少,HER-2阳性胃癌曲妥珠单抗治疗后的组织病理学变化迄今尚未阐明。作者旨在描述HER-2阳性胃癌曲妥珠单抗治疗后胃癌组织反应及其与HER-2状态的相关性。 | Urabe M Ushiku T Seto Y Fukayama M 黄爱清 余英豪 | 2017 | 临床与实验病理学杂志2017，33，5： | 5 |
| 4 | 残胃中EB病毒相关性胃癌:新生和异时残胃癌 | Kaizaki Y. Hosokawa O. Sakurai S. Fukayama M. 李宏宇 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 3 |
| 5 | Epstein-Barr virus-associated gastric carcinoma显示文摘 | Masashi Fukayama Tetsuo Ushiku | 2011 | Pathology - Research and Practice2011，，9： | 2 |
| 6 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
| 7 | Fibrillary inclusions in neoplastic and fetal acinar cells of the pancreas显示文摘 | Chong JM Fukayama M Shiozawa Y | 1996 | Virchows Arch1996，428，45： | 1 |
| 8 | Diagnostic utility of biopsy specimens for autoimmune pancreatitis显示文摘 | Kenji Hirano Noriyoshi Fukushima Minoru Tada Hiroyuki Isayama Suguru Mizuno Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Takashi Sasaki Hirofumi Kogure Yousuke Nakai Naoki Sasahira Takeshi Tsujino Takao Kawabe Masashi Fukayama Masao Omata | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 9 | Photocatalytic activity and photo-induced wettability conversion of TiO2 thin film prepared by sol-gel process on a soda-lime glass显示文摘 | Watanabe Toshiya Fukayama Shigemichi Miyauchi Masahiro Fujishima Akira Hashimoto Kazuhito | 2000 | Journal of Sol-Gel Science and Technology2000，19，13： | 1 |
| 10 | 显示文摘 | Konda H Sugano K Fukayama N | 1994 | Cancer1994，73，6： | 1 |
| 11 | Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics显示文摘 | Noriyoshi Fukushima Masashi Fukayama | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，3： | 1 |
| 12 | Fibrillary inclusions in neoplastic and fetal acinar ceils of the pan- creas显示文摘 | Chong J M Fukayama M Shiozawa Y | 1996 | Virchows Arch1996，428，45： | 1 |
| 13 | Photocataiytic activity and photo-induced wettability conversion of TiO2 thin film prepared by sol-gel process on a sodalime glass显示文摘 | Watanabe T Fukayama S Fujishima M | 2000 | J Sol-Gel Sci & Tech2000，，19： | 1 |
| 14 | Overexpression of CDK4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma 显示文摘 | DOBASHI Y GOTO A FUKAYAMA M | 2004 | Int J Cancer2004，110，4： | 1 |
| 15 | High-level expression of maize phosphoenolpyruvate carboxylase in transgenic rice plants显示文摘 | Ku M.S.B Agarie S Nomurn M Fukayama H Tsuchida H Ono K Hirose S Toki S Miyao M and Matsuoka M | | 0，，： | 1 |
| 16 | Pulmonary fibrosis and lung carcinoma:a comparative study of metaplastic epithelia in honeycombed areas of usual interstitial pneumonia with or without lung carcinoma显示文摘 | Hironaka M Fukayama M | | 0，，： | 1 |
| 17 | Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse显示文摘 | Murril s RJ Fukayama S Boschel i F | | 0，，03： | 1 |
| 18 | Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol 显示文摘 | Klokkevold PR Subar P Fukayama H | 1992 | J Oral Maxillofac surg1992，50，1： | 1 |
| 19 | The different effects of intravenous propofol and midazolam sedation on hemody- namic and heart rate variability显示文摘 | Win NN Fukayama H Kohase H | 2005 | Anesth Analg2005，101，1： | 1 |
| 20 | Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma 显示文摘 | Fukayama M Hino R Uozaki H | 2008 | Cancer Sci2008，99，9： | 1 |
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