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| 1 | Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules显示文摘The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases.Nephrin,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit diaphragm.Podocin was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of French.Podocin binds the cytoplasmic domain of nephrin.After then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.In order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic syndrome.Then we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to nephrin.It is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier function.These molecules could be targets to establish a novel therapy for nephrotic syndrome. | Yoshiyasu Fukusumi Naoko Miyauchi Taeko Hashimoto Akira Saito Hiroshi Kawachi | 2014 | World Journal of Nephrology2014，3，3： | 9 |
| 2 | Low tem- perature bonding process using mixed Cu-Ag nanopartieles显示文摘 | MORISADA Y NAGAOKA T FUKUSUMI M A | 2010 | Journal of Electronic Materials2010，39，12： | 1 |
| 3 | High-temperature oxidation resistance of Ni-A1 Alloy films, prepared by heating electrodeposited composite 显示文摘 | IZAKI M FUKUSUMI M ENOMOTO H OMI T NAKAYAMA Y | 1993 | J Japan lnst Met1993，57，： | 1 |
| 4 | Molecular properties of apelin:tissue distribution and receptor binding显示文摘 | Kawamata Y Habata Y Fukusumi S | | 0，，2： | 1 |
| 5 | New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals显示文摘 | Hinuma S Shintani Y Fukusumi S | 2000 | Nature Cell Biology2000，2，10： | 1 |
| 6 | Molecular properties of apelin:tissue distribution and receptor binding 显示文摘 | Kawamata Y Habata Y Fukusumi S | 2001 | Biochim Biophys Acta2001，1538，23： | 1 |
| 7 | Joint strength of aluminum ultrasonic soldered under liquidus temperature of Sn-Zn hypereutectic solder 显示文摘 | Nagaoka T Morisada Y Fukusumi M | 2009 | Journal of Materials Process- ing Technology2009，209，11： | 1 |
| 8 | Diffuse vascular injury: convergent-type hemorrhage in the supratentorial white matter on susceptibility-weighted image in cases of severe traumatic brain damage显示文摘 | Iwamura A Taoka T Fukusumi A | 2012 | Neuroradiology2012，54，4： | 1 |
| 9 | Joint strength of aluminum ultrasonic soldered under liquidus temperature of Sn-Zn hypereuteetie solder显示文摘 | NAGAOKA T MORISADA Y FUKUSUMI M TAKEMOTO A | 2009 | Journal of Materials Processing Technology2009，209，： | 1 |
| 10 | A new electric current control strategy for EPS motors显示文摘 | Masahiko Kurishige Kouji Fukusumi Noriyuki Inoue | 2001 | SAE2001，，1： | 1 |
| 11 | Joint strength of a- luminum ultrasonic soldered under liquidus temperature of Sn-Zn hypereutectie solder显示文摘 | Nagaokaa T Morisada Y Fukusumi M | 2009 | Journal of Materials Processing Technol- ogy2009，209，11： | 1 |
| 12 | Superplasticity in a fullerene-dispersed Mg-Al-Zn alloy composite显示文摘 | WATANABE H FUKUSUMI M ISIKAWA K SHIMIZU T | 2006 | Scripta Materialia2006，54，： | 1 |
| 13 | Fabrication of nanostructured tool steel layer by combination of laser cladding and friction stir processing显示文摘 | Yoshiaki Morisada Hidetoshi Fujii Tadashi Mizuno Genryu Abe Toru Nagaoka Masao Fukusumi | 2010 | Surface & Coatings Technology2010，，11： | 1 |
| 14 | High-temperature compressive deformation behavior of Mg97Zn1Y2 extruded alloy containing a long-period stacking ordered (LPSO) phase 显示文摘 | Hagihara K Kinoshita A Fukusumi Y | 2013 | Materials Science and Engineering A2013，560，： | 1 |
| 15 | Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor显示文摘 | Kazuhiko Tatemoto Masaki Hosoya Yugo Habata Ryo Fujii Tadao Kakegawa Min-Xu Zou Yuji Kawamata Shoji Fukusumi Shuji Hinuma Chieko Kitada Tsutomu Kurokawa Haruo Onda Masahiko Fujino | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 16 | Molecular properties of apelin:tissue distribution and receptor binding显示文摘 | Kawamata Y Habata Y Fukusumi S | 2001 | Biochim Biophys Acta2001，1538，23： | 1 |
| 17 | Molecular properties of apelin:tissue distribution and receptor binding显示文摘 | Kawamata Y Habata Y Fukusumi S | | 0，，： | 1 |
| 18 | Analyses for susceptibility of rat anterior pituitary cells to prolactin-releasing peptide显示文摘 | KAWAMATA Y FUJII R FUKUSUMI S | 2000 | Endocrine2000，12，3： | 1 |
| 19 | Mechanical properties and texture of a superplastical deformed AZ31 magnesium alloy显示文摘 | Watanabe H Fukusumi M | 2008 | Materials Science and Engineering A2008，477，： | 1 |
| 20 | Molecular properties of apelin: tissue distribution and receptor binding显示文摘 | Kawamata Y Habata Y Fukusumi S | 2001 | Biochem Biophys Acta2001，1538，23： | 1 |
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