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| 1 | Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer显示文摘AIM:To investigate differences between common gastric cancer andα-fetoprotein(AFP)-producing gastric cancer according to the presence or absence of liver metastasis.METHODS:Between 1997 and 2011,1299 patients underwent gastrectomy for gastric cancer(GC)at our institute and their hospital records were reviewed retrospectively.Patients were immunohistochemically divided into two groups:23 patients(1.8%)with AFPproducing GC and 1276 patients(98.2%)without it.RESULTS:AFP-producing GC patients had a significantly higher incidence of deeper tumors,venous invasion,lymphatic invasion,lymph node metastasis,and liver metastasis and a poorer prognosis(P<0.005)than those without AFP-producing GC.However,multi-variate analysis revealed that AFP-positivity was not an independent prognostic factor.The prognosis of AFPproducing GC was similar to that of AFP-non producing GC according to the presence or absence of liver metastasis.Concerning recurrence,47.8%of patients(11/23)with AFP-producing GC and 20.0%of patients(256/1276)without AFP-producing GC exhibited recurrence.Liver metastasis[90.9%(10/11)]was the most prevalent in AFP-producing GC patients.Multivariate analysis revealed that liver metastasis was the only independent prognostic factor in AFP-producing GC(HR=17.6,95%CI:2.1-147.1;P=0.0081).CONCLUSION:AFP-producing GC is similar to common GC without liver metastasis,which should be specifically targeted in an effort to improve the prognosis of AFP-producing GC patients. | Shoji Hirajima Shuhei Komatsu Daisuke Ichikawa Takeshi Kubota Kazuma Okamoto Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Hisashi Ikoma Eigo Otsuji | 2013 | World Journal of Gastroenterology2013，19，36： | 33 |
| 2 | Linking uric acid metabolism to diabetic complications显示文摘Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase(XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid(UA) generation inhibitor in the 1950 s and has been routinely used for gout prevention since then. Serum UA levels are an important risk factor of disease progression for various diseases, including those related to lifestyle. Recently, other UA generation inhibitors such as febuxostat and topiroxostat were launched. The emergence of these novel medications has promoted new research in the field. Lifestyle-related diseases, such as metabolic syndrome or type 2 diabetes mellitus, often have a common pathological foundation. As such, hyperuricemia is often present among these patients. Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Interventional studies for UA generation, not UA excretion revealed XDH/XO can be the therapeutic target forvascular injury and renal dysfunction. In this review, the relationship between UA metabolism and diabetic complications is highlighted. | Akifumi Kushiyama Kentaro Tanaka Shigeko Hara Shoji Kawazu | 2014 | World Journal of Diabetes2014，5，6： | 19 |
| 3 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 4 | Treatment of gastric remnant cancer post distal gastrectomy by endoscopic submucosal dissection using an insulation-tipped diathermic knife显示文摘AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with gastric remnant cancer. METHODS: Thirty-two patients with early gastric cancer in the remnant stomach, who underwent distal gastrectomy due to gastric carcinoma, were treated with endoscopic mucosal resection (EMR) or ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 10-year period from January 1998 to December 2007, including 17 patients treated with IT-ESD. Retrospectively, patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, and perforation rate were compared between patients treated with conventional EMR and those treated with IT-ESD. RESULTS: The CR rate (40% in the EMR group vs 82% in the IT-ESD group) was significantly higher in the IT-ESD group than in the EMR group; however, the operation time was significantly longer for the IT- ESD group (57.6 ± 31.9 min vs 21.1 ± 12.2 min). No significant differences were found in the rate of underlying cardiopulmonary disease (IT-ESD group, 12% vs EMR group, 13%), one-piece resection rate (100% vs 73%), bleeding rate (18% vs 6.7%), and perforation rate (0% vs 0%) between the two groups. CONCLUSION: IT-ESD appears to be an effective treatment for gastric remnant cancer post distal gastrectomy because of its high CR rate. It is useful for histological confirmation of successful treatment. Thelong-term outcome needs to be evaluated in the future. | Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujitav Shuji Matsumura Seiyuu Suzuki | 2008 | World Journal of Gastroenterology2008，14，16： | 18 |
| 5 | Present status of endoscopic mastectomy for breast cancer显示文摘Endoscopy is now being used for breast cancer surgery. Though it is used for mastectomy, lymph node dissection, and breast reconstruction, its prime use is for mastectomy. Because an incision can be placed inconspicuously in the axillary site, a relatively largeincision can be created. A retractor with an endoscope, CO2, and an abrasion device with the endoscope are used for operation space security. It is extremely rare that an endoscope is used for lymph node dissection. For breast reconstruction, it may be used for latissimus muscle flap making, but an endoscope is rarely used for other reconstructions. Endoscopic mastectomy is limited to certain institutions and practiced hands, and it has not been significantly developed in breast cancer surgery. On the other hand, endoscopic surgery may be used widely in breast reconstruction. With respect to the spread of robotic surgery, many factors remain uncertain. | Tetsuhiro Owaki Yuko Kijima Heiji Yoshinaka Munetsugu Hirata Hiroshi Okumura Simiya Ishigami Yasuhito Nerome Toshiro Takezaki Shoji Natsugoe | 2015 | World Journal of Clinical Oncology2015，6，3： | 15 |
| 6 | Innovative use of controlled availability fertilizers with high performance for intensive agriculture and environmental conservation显示文摘A variety of slow release fertilizers, controlled release (availability) fertilizers (CAFs),and stability fertilizers have been developed in response to the serious drawbacks of the conventional fertilizers since the early 1960's. Of these fertilizers, CAFs which are coated with resin are consumed in the largest quantity in the world. Selecting CAFs with higher performance, the author will discuss about: 1) Innovation of agro-technologies for various field crops including new concepts of fertilizer application, 2) high yielding of field crops, 3) enhancing quality and safety of farm products, and 4) controlling the adverse effect of intensive agriculture on the environment. | Sadao SHOJI | 2005 | Science China(Life Sciences)2005，48，z2： | 14 |
| 7 | Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife显示文摘AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with over 20 mm early gastric cancer (EGC). METHODS: A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group (21-40 mm)] and the remaining patients (under 20 mm group). RESULTS: We found no significant difference in the rate of underlying cardiopulmonary disease (over 20 mm group vs under 20 mm group, 5.0% vs 5.6%), one- piece resection rate (95% vs 96%), CR rate (85% vs 89%), operation time (72.3 min vs 66.5 min), bleeding rate (5% vs 4.2%), and perforation rate (0% vs 1.4%) between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION: There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future. | Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujita Fusao Ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki | 2007 | World Journal of Gastroenterology2007，13，29： | 13 |
| 8 | Comparison of conventional and inverted A^2/O processes:Phosphorus release and uptake behaviors显示文摘Two full-scale systems operated in parallel,a conventional A 2 /O system consisting of anaerobic,anoxic and oxic compartments in succession and an inverted system consisting of anoxic,anaerobic and oxic compartments without internal recycle,were compared in terms of their phosphorus removal performance,with an emphasis on phosphate(P) release behaviors,using both operational data and simulation results.The inverted system exhibited better long-term phosphorus removal performance(0.2 ± 0.3 vs.0.7 ± 0.7 mg/L),which should be attributed to the higher P release rate(0.79 vs.0.60 kg P/(kg MLSS·day)) in the non-aerated compartments.The P release occurred in both the anoxic and anaerobic compartments of the inverted system,resulting in more efficient P release.Although the abundances of the 'Candidatus Accumulibacter phosphatis' population in the two systems were quite similar((19.1 ± 3.27)% and(18.4 ± 4.15)% of the total microbe(DAPI stained particles) population in the inverted and conventional systems,respectively,by fluorescence in situ hybridization(FISH)),the high-concentration DAPI staining results show that the abundances of the whole polyphosphate accumulating organisms(PAOs) in the aerobic ends were quite different(the average ratios of the poly-P granules to total microbes(DAPI stained particles) were(45 ± 4.18)% and(35 ± 5.39)%,respectively).Both the operational data and simulation results showed that the inverted system retained more abundant PAO populations due to its special configuration,which permitted efficient P release in the non-aerated compartment and better P removal. | Rong Qi Tao Yu Zheng Li Dong Li Takashi Mino Tadashi Shoji Kochi Fujie Min Yang | 2012 | Journal of Environmental Sciences2012，24，4： | 11 |
| 9 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 10 | The Clock Protein CCA1 and the bZIP Transcription Factor HY5 Physically Interact to Regulate Gene Expression in Arabidopsis显示文摘生理节奏的钟调整象编码轻收获的叶绿素 A/B (Lhcb ) 的那些那样的一连串的 Arabidopsis 基因的表示蛋白质。我们以前学习了二这些 Arabidopsis genesLhcb1 *1 的倡导者, Lhcb1 *3and 识别了绑钟蛋白质的一个序列联系的生理节奏的钟 1 (CCA1 ) 。这个序列,指明的 CCA1 有约束力的地点(CBS ) ,为 phytochrome 和这些基因的生理节奏的应答是必要的。在到这个序列的靠近的最近,在那里存在被显示了在另外的调整光的植物倡导者绑 bZIP 抄写因素 HY5 的一个 G 盒子核心元素。在现在的学习,我们检验了抄写因素绑定的相互作用的重要性在 Lhcb 基因的正常生理节奏的有韵律的表示的控制的 CBS 和 G 盒子核心元素。我们的结果证明 HY5 能明确地在 Lhcb 倡导者绑 G 盒子元素并且 CCA1 能改变 HY5 的有约束力的活动。我们进一步证明 CCA1 和 HY5 罐头身体上交往并且他们能在酵母记者基因试金对抄写 synergistically 起作用。HY5 的缺席导致 Lhcb1 *1 的一个更短的时期生理节奏的表示但是不影响 CATALASE3 (CAT3 ) 的生理节奏的表示,其倡导者缺乏一个 G 盒子元素。我们的结果建议 Lhcb 倡导者上的 HY5 和 CCA1 蛋白质的那个相互作用为 Lhcb 基因的正常生理节奏的表示是必要的。 | Christos Andronis Simon Barak Stephen M. Knowles Shoji Sugano Elaine M. Tobin | 2008 | Molecular Plant2008，1，1： | 9 |
| 11 | Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts显示文摘以前的研究显示了那脂肪的多糖(LPS ) 在匾的 fromGram 否定的细菌导致前列腺素 E_2 (PGE_2 ) 的版本,它在吸烟的 periodontitis,和那棵烟草支持牙槽的骨头再吞可能是为 periodontitis 的发展和严厉的一个重要风险因素。我们在碱性磷酸酶(ALPase ) 上决定了烟碱 andLPS 的效果活动, PGE_2 生产,和表示 ofcyclooxygenase (COX-1, COX-2 ) , PGE_2 受体 Ep1-4,和在人的 osteoblastic Saos-2 房间的巨噬细胞殖民地刺激因素(M-CSF ) 。房间与 10 ~ 是有教养的(-3) M 烟碱面对 0, 1,或 10 μ g /ml LPS,或与 LPS 独自一个。ALPase 活动独自在与烟碱或 LPS 有教养的房间减少了,并且在与烟碱和 LPS 有教养的那些进一步减少了,而 PGE_2 生产显著地在前者增加了并且在后者进一步增加了。由自己,烟碱没影响 COX-1, COX-2,任何 PGE_2 受体,或 M-CSF 的表示,但是烟碱和 LPS 什么时候是现在, COX-2 的表示, Ep3, Ep4,和 M-CSF,显著地增加。10 ~ 的同时的增加(-4) M 消炎痛在 ALPase 活动, PGE_2 生产,和 M-CSF 表示消除了烟碱和 LPS 的效果。proteinkinase A 的 Phosphorylation 在与烟碱和 LPS 有教养的房间高。这些结果建议 LPS 由造骨细胞的 COX-2 表示的增加提高导致烟碱的 PGE_2 的生产, thatnicotine-LPS-induced PGE_2 首先在 autocrine orparacnne 模式与造骨细胞 Ep4 受体交往,并且 nicotine-LPS-induced PGE_2 然后减少 ALPase 活动和 increasesM-CSF 表示。 | Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 9 |
| 12 | Chemical Studies on the Glycosides in the Leaves of Oplopanax Elatus Nakai(Ⅳ)显示文摘ChemicalStudiesontheGlycosidesintheLeavesofOplopanaxElatusNakai(Ⅳ)*WANGGuang-shuandXUJing-da(NormanBethuneUniversityofMedical... | WANG Guang shu and XU Jing da (Norman Bethune University of Medical Sciences, Changchun, 130021) MA Xiu li, SUN Yun xiu and LIU Ju zheng (Department of Chemistry, Jilin University, Changchun, 130023) Tetsuya Murayama and Junzo Shoji (Schoo | 1997 | Chemical Research in Chinese Universities1997，13，1： | 6 |
| 13 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 14 | Occurrence of perfluoroalkyl acids in precipitation from Shenyang,China显示文摘Perfluorosulfonates (PFSAs) and perfluorocarboxylates (PFCAs) in precipitation collected from Shenyang, China were determined. Snow samples were collected in the snow event on March 4, 2007 from 34 sites involving both the urban and suburban areas in Shenyang. The snowmelt was preconcentrated by solid phase extraction and analyzed using LC-MS method. Measurable amounts of perfluoroalkyl acids (PFAS) were found in precipitation samples from Shenyang, demonstrating that wet deposition is one possible pathway for the removing of the selected PFAS chemicals from atmosphere. Major PFAS detected were PFOS (<0.38―51 ng/L), PFOA (0.82―13 ng/L) and PFHpA (0.76―11 ng/L), with their mean concentration of 5.4, 3.3 and 2.9 ng/L, respectively. Other PFSAs and PFCAs were detected at much lower frequency or below the limit of detection in all the samples. The work presented here offers some basis for the investigation on the environmental behavior and the evaluation of human exposure to PFAS. | LIU Wei DONG GuangHui JIN YiHe SASAKI Kazuaki SAITO Norimitsu SATO Itaru TSUDA Shuji NAKAYAMA Shoji F | 2009 | Chinese Science Bulletin2009，54，14： | 6 |
| 15 | 膨胀石墨吸油特性的研究显示文摘通过对不同形态和填充密度的膨胀石墨(EG)进行的毛细吸附实验,着重研究了EG的比表面积和填充密度对吸油特性的影响.实验结果表明:细颗粒状EG样品的比表面积从0 624m2/g到34 20m2/g显著变化时,对柴油吸附率的改善并不显著;与细颗粒状EG样品相比,大颗粒蠕虫状样品具有更高的吸附率;填充密度的变化对A级重油吸附率有显著影响. | 陈跃军 Shoji Muro Jǖrgen Walter 戴光泽 | 2003 | 西南交通大学学报2003，38，6： | 6 |
| 16 | Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin显示文摘 | Takahiro Araki Masanori Emoto Megumi Teramura Hisayo Yokoyama Katsuhito Mori Sawako Hatsuda Takaaki Maeno Kayo Shinohara Hidenori Koyama Tetsuo Shoji Masaaki Inaba Yoshiki Nishizawa | 2006 | Metabolism2006，，8： | 5 |
| 17 | Homologue of mammalian apolipoprotein A-II in non-mammalian vertebrates显示文摘尽管有分子的重量的 apolipoprotein 14 kDa (apo-14 kDa ) 与鱼血浆被联系高密度的脂蛋白(HDL ) , apo-14 kDa 是否是哺乳动物的 apoA-II 的相当或相同事物,尚待坚定。我们获得了编码日本鳗和彩虹鳟鱼 apo-14 kDa 的完整的 cDNA 序列。日本鳗 apo-14 kDa 顺序的相当或相同事物能在在 DDBJ/EMBL/GenBank 或 TGI 数据库扔的 14 鱼种类被发现。鱼 apo-14 kDa 缺乏 propeptide 并且比哺乳动物的 apoA-II 包含更内部的重复。不过,种系发生的分析允许鱼 apo-14 kDa 是哺乳动物的 apoA-II 的相当或相同事物。在 TGI 克隆的 silico,另外, Ensembl,或 NCBI 数据库表明在狗,鸡,绿 anole 蜥蜴,和非洲人的 apoA-IIs 抓了其序列到目前为止一直不可得到的青蛙,建议两 apoA -- 我和 apoA-II 脊椎动物 HDL 的同样基本的成分。 | Malay Choudhury Shoji Yamada Masaharu Komatsu Hideki Kishimura Seiichi Ando | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 5 |
| 18 | CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis显示文摘Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from surgery.Methods: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December 2012.These patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate analyses.Results: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL. | Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 19 | Topical nitrate drip infusion using cystic duct tube for retained bile duct stone:A six patients case series显示文摘A retained bile duct stone after operation for cholelithiasis still occurs and causes symptoms such as biliary colic and obstructive jaundice.An endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy(EST),followed by stone extraction,are usually an effective treatment for this condition.However,these procedures are associated with severe complications including pancreatitis,bleeding,and duodenal perforation.Nitrates such as glyceryl trinitrate(GTN) and isosorbide dinitrate(ISDN) are known to relax the sphincter of Oddi.In 6 cases in which a retained stone was detected following cholecystectomy,topical nitrate drip infusion via cystic duct tube(C-tube) was carried out.Retained stones of 2-3 mm diameter and no dilated common bile duct in 3 patients were removed by drip infusion of 50 mg GTN or 10 mg ISDN,which was the regular dose of intravenous injection.Three other cases failed,and EST in 2 cases and endoscopic biliary balloon dilatation in 1 case were performed.One patient developed an adverse event of nausea.Severe complications were not observed.We consider the topical nitrate drip infusion via C-tube to be old but safe,easy,and inexpensive procedure for retained bile duct stone following cholecystectomy,inasmuch as removal rate was about 50% in our cases. | Masatoshi Shoji Hiroshi Sakuma Yutaka Yoshimitsu Tsutomu Maeda Masuo Nakai Hiroshi Ueda | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 4 |
| 20 | Isolation and Structure Elucidation of New Glycosides from the Leaves of Oplopanax Elatus Nakai(Ⅱ)显示文摘IsolationandStructureElucidationofNewGlycosidesfromtheLeavesofOplopanaxElatusNakai(Ⅱ)WANGGuang-shu,ZHAOChun-fangandXUJing-da(... | WANG Guang-shu ZHAO Chun-fang and XU Jing-da(Bethune University of Medical Sciences, Changchun,130021 )Tetsuya Murayama and Junzo Shoji(School of Pharmaceutical Showa University,Tokyo 142 ) | 1994 | Chemical Research in Chinese Universities1994，10，4： | 4 |
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