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| 1 | Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models显示文摘Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation surgery.Understanding the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor grafts.The initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte necrosis.Some adaptive pathways are activated during reperfusion that reduce the reperfusion injury.IRI involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ pathways.Transgenic animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological studies.Targeted disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same protein.This article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI. | Gourab Datta Barry J Fuller Brian R Davidson | 2013 | World Journal of Gastroenterology2013，19，11： | 50 |
| 2 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 3 | 头颈部鳞癌的条件生存率显示文摘头颈部鳞癌(HNSCC)患者生存率的统计通常是从疾病被诊断时开始.但对疾病确诊后生存一段时间的患者很少应用条件生存率(conditional survival,CS)进行分析,CS分析能够提供判断患者预后的重要信息。该文旨在应用大规模的癌症数据库寻求CS参数。对1973~1998年间美国国立癌症研究院(the National Cancer Institute。NCI)的监测、流行病学和最终结果(the surveillance,epidemiology and end-results,SEER)计划(Surveillance.Epidemiology,and End Results, | Fuller CD Wang S J Thomas CR Jr | 2007 | 中国口腔颌面外科杂志2007，5，3： | 5 |
| 4 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 5 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 6 | Regulation of putative fatty acid transpoters and acyl-CoA synthetase in liver and adipose tissue in ob/ob Mice显示文摘 | Memon R A Fuller J Moser A H | 1999 | Diabetes1999，48，2： | 2 |
| 7 | Characteristics of wave propagation and energy distributions in cylindrical elastic shells filled with fluid显示文摘 | Fuller C R Fahy F J | 1982 | JSV1982，81，4： | 2 |
| 8 | Psychological benefits of greenspace increase with biodiversity显示文摘 | Fuller Richard A Irvine Katherine N Devine-Wright Patrick Warren Philip H Gaston Kevin J | 2007 | Biology Letters2007，，4： | 2 |
| 9 | The Characterisation and Measurement of Land Cover Change Through Remote Sensing: Problems in Operational Applications显示文摘 | Fuller R M Smith G M Devereux B J | 2003 | International Journal of Applied Earth Observation and Geoinformation2003，4，： | 1 |
| 10 | Magnetic material in the human hippocampus显示文摘 | Dunn JR Fuller M Zoeger J | 1995 | Brain Res Bull1995，36，2： | 1 |
| 11 | Content-based image and video retrieval显示文摘 | Bach J Fuller C Gupta A | 2005 | Signal Processing2005，85，2： | 1 |
| 12 | Sonic testing a simple nondestructive testing for verifying casting quality 显示文摘 | Fuller A G Emerson P J Rew R | 1963 | BCIRA Journal1963，，11： | 1 |
| 13 | Endovascular treatment of popliteal artery aneurysms: a single- center experience显示文摘 | Etezadi V Fuller J Wong S | 2010 | J Vasc Interv Radiol2010，21，： | 1 |
| 14 | Pheochromocytoma and pregnancy: a case report and review of anesthetic management显示文摘 | Dugas G Fuller J Singh S | 2004 | Can J Anaesth2004，51，2： | 1 |
| 15 | An error analysis of failure prediction techniques derived from fracture mechanics 显示文摘 | Wiederhom S M Fuller E R Mandel J | 1976 | Journal of the American Ceramic Society1976，59，910： | 1 |
| 16 | Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs显示文摘 | Russell J R Fuller J D Macaulay M | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
| 17 | Active control of coupled waved propagation in fluid-filled elastic shell 显示文摘 | Brevar B J Fuller C R | 1993 | Journal of Sound and Vibration :1993，94，3： | 1 |
| 18 | Characteristics of wave propagation and energy distributions in cylindrical elastic shells filled with fluid显示文摘 | Fuller C R Fahy F J | 1982 | Journal of Sound and Vibration1982，81，4： | 1 |
| 19 | Thermal stability of LixCoO2,LixNiO2 and LixMnO2 and consequences for the safety of Li-ion cells显示文摘 | DAHN J R FULLER E W OBROVAC M | 1994 | Solid State Ionics1994，69，： | 1 |
| 20 | Integrated CFD modeling of gas turbine combustion 显示文摘 | Fuller E J smith C E | 1993 | AIAA-93-21961993，，： | 1 |
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