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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 3 | Outcomes of right-lobe and left-lobe living-donor liver transplantations using small-for-size grafts显示文摘AIM To analyze the outcomes of living-donor liver transplantation(LDLT) using left-lobe(LL) or right-lobe(RL) small-for-size(SFS) grafts.METHODS Prospectively collected data of adult patients who underwent LDLT at our hospital in the period from January 2003 to December 2013 were reviewed. The patients were divided into the RL-LDLT group and the LL-LDLT group. The two groups were compared in terms of short-and long-term outcomes, including incidence of postoperative complication, graft function, graft survival, and patient survival. A SFS graft was defined as a graft with a ratio of graft weight(GW) to recipient standard liver volume(RSLV)(GW/RSLV) of < 50%. The Urata formula was used to estimate RSLV.RESULTS Totally 218 patients were included for analysis, with 199 patients in the RL-LDLT group and 19 patients in the LL-LDLT group. The two groups were similar in terms of age(median, 53 years in the RL-LDLT group and 52 years in the LL-LDLT group, P = 0.997) but had significantly different ratios of men to women(165:34 in the RL-LDLT group and 8:11 in the LL-LDLT group, P < 0.0001). The two groups were also significantly different in GW(P < 0.0001), GW/RSLV(P < 0.0001), and graft cold ischemic time(P = 0.007). When it comes to postoperative complication, the groups were comparable(P = 0.105). Five patients died in hospital,4(2%) in the RL-LDLT group and 1(5.3%) in the LLLDLT group(P = 0.918). There were 38 graft losses, 33(16.6%) in the RL-LDLT group and 5(26.3%) in the LL-LDLT group(P = 0.452). The 5-year graft survival rate was significantly better in the RL-LDLT group(95.2% vs 89.5%, P = 0.049). The two groups had similar 5-year patient survival rates(RL-LDLT: 86.8%, LL-LDLT: 89.5%, P = 0.476).CONCLUSION The use of SFS graft in LDLT requires careful tailormade surgical planning and meticulous operation. LLLDLT can be a good alternative to RL-LDLT with similar recipient outcomes but a lower donor risk. Further research into different patient conditions is needed in order to validate the use of LL graft. | Wong Hoi She Kenneth SH Chok James YY Fung Albert CY Chan Chung Mau Lo | 2017 | World Journal of Gastroenterology2017，23，23： | 4 |
| 4 | Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model显示文摘 | Ferrier MC Sarin H Fung SH | 2007 | Neoplasia2007，9，7： | 1 |
| 5 | Estimation of the basic reproduction number of enterovirus 71 and coxsackie virus A16 in hand, foot and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 6 | Adefovir resistant hepatitis B can be associated with viral rebound and hepatic decompensation显示文摘 | Fung SK Andreone P Han SH | 2005 | J Hepatol2005，43，6： | 1 |
| 7 | Oncogenic role of EIF-5A2 inthe development of ovarian cancer显示文摘 | Guan XY Fung JM Lau SH | 2004 | Cancer Res2004，64，： | 1 |
| 8 | Anti-NMDA receptor en- cephalitis with atypical brain changes on MRI 显示文摘 | Chan SH Wong VC Fung CW | 2010 | Pediatr Neu- ro12010，43，4： | 1 |
| 9 | Estimation of the basic reproduction number of enterovirus 71 and Coxsackievirus A16 in hand, foot, and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infact Dis J2011，30，8： | 1 |
| 10 | MR diffusion imaging in ischemic stroke 显示文摘 | Fung SH Roccatagliata L Gilberto RG | 2011 | Neuroimaging Clin N Am2011，21，2： | 1 |
| 11 | Anti-NMDA receptor encephalitis with atypical brain changes on M RI 显示文摘 | Chan SH Wong VC Fung CW | 2010 | Pediatr Neurol2010，43，4： | 1 |
| 12 | Renal papillary necrosis:review and comparison of findings at multi-detector row CT and intravenous urography显示文摘 | Fung DC Kim SH Fung SI1 | 2006 | Radiographics2006，26，： | 1 |
| 13 | Evaluation of the Confusion Assessment Method (CAM) as a screening tool for delirium in the emergency room显示文摘 | Monette JV Galbaud du Fort G Fung SH | 2001 | Gen Hop Psychiatry2001，23，1： | 1 |
| 14 | Estimation of the basic reproduc- tion number of enterovirus 71 and coxsackievirus A16 in hand, foot, and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 15 | Adefovir - resistant hepatitis B can be associated with viral rebound andhepatic de- compensation显示文摘 | Fung SK Andrcone P Han SH | 2005 | J Hepatol2005，43，6： | 1 |
| 16 | Stroke risk among Chinese immigrants in New York City显示文摘 | Fang J Foo SH Fung C | 2006 | J Immigr Minor Health2006，8，： | 1 |
| 17 | Estimation of the basic reproduc- tion number of enterovirus 71 and coxsackievirus AI6 in hand, foot, and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 18 | Estimation of the basic reproduction number of enterovirus 71 and coxsakie-virus A16 in hand,and mouth disease outbreak显示文摘 | MA E FUNG C YIP SH | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 19 | Adefovir-resistant hepatitis B can be associated with viral rebounde and hepatic decomposition 显示文摘 | Fung SK Andreone P Han SH | 2005 | J Heppatol2005，43，6： | 1 |
| 20 | A graph-theoretical analysis algo- rithm for quantifying the transition from sensory in- put to motor output by an emotional stimulus 显示文摘 | Karmonik C Fung SH Dulay M Verma A Grossman RG | 2013 | Conf Proc IEEE Eng Med Biol Soc2013，2013，： | 1 |
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