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| 1 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 2 | Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G_1 cell cycle arrest and apoptosis: A quantitative proteomic study显示文摘Objective: The present study aimed to investigate the molecular events in alisol B 23-acetate(ABA) cytotoxic activity against a liver cancer cell line.Methods: First, we employed a quantitative proteomics approach based on stable isotope labeling by amino acids in cell culture(SILAC) to identify the different proteins expressed in HepG2 liver cancer cells upon exposure to ABA. Next, bioinformatics analyses through DAVID and STRING on-line tools were used to predict the pathways involved. Finally, we applied functional validation including cell cycle analysis and Western blotting for apoptosis and mTOR pathway-related proteins to confirm the bioinformatics predictions.Results: We identified 330 different proteins with the SILAC-based quantitative proteomics approach. The bioinformatics analysis and the functional validation revealed that the mTOR pathway, ribosome biogenesis, cell cycle, and apoptosis pathways were differentially regulated by ABA. G1 cell cycle arrest, apoptosis and mTOR inhibition were confirmed.Conclusions: ABA, a potential mTOR inhibitor, induces the disruption of ribosomal biogenesis. It also affects the mTOR-MRP axis to cause G1 cell cycle arrest and finally leads to cancer cell apoptosis. | Ji Xia Qiang Luo Shengbin Huang Fuquan Jiang Lin Wang Guanghui Wang Jingjing Xie Jie Liu Yang Xu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
| 3 | Preparative separation of alkaloids from The root of Sophora flavescens Ait by pH-zone-refining counter-current chromatography显示文摘 | Fuquan Yang Jiang Quan Tianyou Zhang | 1998 | Chromatogr A1998，822，2： | 1 |
| 4 | Multidimensional Counter-current Chromatographic System and its Application显示文摘 | Yang Fuquan Quan Jiang Zhang Tianyou | 1998 | Chromatogr A1998，803，： | 1 |
| 5 | Large-scale synthesis well-dispersed ZnS microspheres and their photoluminescence, photocatalysis properties显示文摘 | Xinjun Wang Fuquan Wan Kun Han Chunxia Chai Kai Jiang | 2008 | Materials Characterization2008，，： | 1 |
| 6 | Fingerprinting quality control of Qianghuo by high - performance liquid chromatography - photodiode array detection显示文摘 | Fuquan Jiang Yanduo Tao Yun Shao | 2007 | Journal of Ethnopharmacology2007，111，： | 1 |
| 7 | Multidimensional counter-current chromatographic system and its application显示文摘 | Fuquan Yang Jiang Quan Tian You Zhang | 1998 | Journal of Chromatography A1998，802，： | 1 |
| 8 | Amplification and cloning of the full-length genome of Japanese encephalitis virus by a novel long RT-PCR protocol in a cosmid vector显示文摘 | Fuquan Zhang Qingsheng Huang Wenyu Ma Shaozhun Jiang Yingru Fan Hongyi Zhang | 2001 | Journal of Virological Methods2001，，2： | 1 |
| 9 | Preparative separation of alkaloids from the root of Sophora flaveseens Air by pH- zone- refining counter- current chromatography 显示文摘 | Fuquan Yang Jiang Quan Tianyou Zhang | 1998 | Journal of Chromatography A1998，822，： | 1 |
| 10 | A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome显示文摘As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B. | Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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