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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Influence of pesticides and alfalfa on soilbiological properties显示文摘Several biochemical parameters, such as respiration rate (RIP) , biomass - C oxygen demand , andATP reflecting microorganism biomass and activities were determined. All soil samples were incubated at22℃ , 14. 5 ℃ for 60, 192 and 480h, respectively. All th | Ma Ruixia Sun Sien(Research Center for Eco Environmental Sciences , Chinese Academy of Sciences . Beijing 100085 , China) R. Hantschel, F. Beese(GSF - Institut fur the ecologic, Ingolstter Landstraβe 1 , D-8042 Neuherberg, Germany) | 1995 | Journal of Environmental Sciences1995，7，2： | 2 |
| 3 | Magnetic resonance imaging reveals functional diversity of the vasculature in benign and malignant breast lesions显示文摘 | FUR MAN-HARAN E SCHECHTMAN E KELCZ F | | 0，，04： | 1 |
| 4 | Lobectomy performed through a video-assisted minithoracotomy as a new technique in our clinical practice显示文摘 | Furák J Bács E Grochulski R | 2008 | Magy Seb2008，61，1： | 1 |
| 5 | Excavations in molecular crystals 显示文摘 | Le Fur E Dcmcrs E Maris T | 2003 | Chem Commun2003，，： | 1 |
| 6 | Effects of exercise- induced intracellular acidosis on the phosphocreatiue recovery kinetics: a ^31P- MRS study in three muscle groups in humans显示文摘 | Layec G Malucelli E Le Fur Y | 2013 | NMR Biomed2013，26，11： | 1 |
| 7 | Phylogeny of Cyperaceae based on DNA sequence data- a new rbcL analysis 显示文摘 | Simpson DA Muasya AM Alves MV Bruhl J J Dhooge S Chase MW Furness CA Ghamkhar K Goetghebeur P Hodkinson TR Marchant AD Reznicek AA Nieuwborg R Roalson EH Smets E Starr JR Thomas WW Wilson KL Zhang XF | 2007 | Ali- so2007，23，： | 1 |
| 8 | Magnetic and Thermal Properties of Vanadium Phosphates Hydrates MⅡ(VOPO)2*4H2O (MⅡ=Ca2+,Ba2+ and Cd2+)显示文摘 | Le Fur E Pena O Pivan J Y | 1999 | Journal of Alloys and Compounds1999，285，： | 1 |
| 9 | Car colour and risk of car crash injury: population based case control study显示文摘 | Furness S Connor J Robinson E | 2003 | BMJ2003，327，7429： | 1 |
| 10 | Localiza- tion of P2X2 and P2X3 receptors in rat trigeminal ganglion neu- rons显示文摘 | Staikopoulos V Sessle B J Furness J B Jennings E A | 2007 | Neuroscience2007，144，： | 1 |
| 11 | Lobectomy performed through avideo-assisted mini thoracotomy as a new technique in our clinical practice显示文摘 | Furák J Bács E Grochulski R | 2008 | Magy Seb2008，61，1： | 1 |
| 12 | Inter- ventions for treating oral mucositis for patient with can- cer receiving treatment显示文摘 | Clarkson J E Worthington H V Furness S | 2010 | Cochrane Dtabase Syst Rev2010，，8： | 1 |
| 13 | The brightness distribution over the moon's disk at 6 cm wavelength 显示文摘 | Hirth W Butz M Furs E | 1976 | Earth Moon and Planets1976，15，3： | 1 |
| 14 | Reconstruetive of bladder using porcine acellaular matrix显示文摘 | KOLLIYIAN M E FURNESS P D | 1997 | Pediatrics1997，100，3： | 1 |
| 15 | The participation of the sympathetic innervation of the gastrointestinal tract in disease states显示文摘 | Lomax A E Sharkey K A Furness J B | 2010 | Neurogastroenterol Motil2010，22，1： | 1 |
| 16 | Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by non-isotopic in situ hybridization 显示文摘 | Bailey E Bottomley MJ Westwell S Pringle JH Furness PN Feehally J | 1999 | J Clin Pathol1999，52，10： | 1 |
| 17 | Inter- ventions for treating oral mucositis for patients with cancer receiving treatment显示文摘 | Clarkson J E Worthington H V Furness S | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 18 | The participation of the sympathetic innervation of the gastrointestinal tract in disease states 显示文摘 | Lomax A E Sharkey K A Furness J B | 2010 | Neurogastroenterol Motil2010，22，1： | 1 |
| 19 | Magnetothermal Analysis of Nanocrystallization of Amorphous and Relaxations of Nanocrystalline Materials显示文摘For a few years it has been realized that nanocrystalline phases can be formed during crystallization of amorphous alloys annealed isothermally below the crystallization temperature of usual heating experiments. Data of this transformation monitored by the measurement of magnetic susceptibility are presented. A method using a magnetic balance with electronic stabilisation and combined computer facilities is applied. Constant heating and cooling rates as well as isothermal heat treatments are used. Magnetic measurements are able to detect the onset of the transformation of amorphous Ni-P alloys much earlier than was possible with differential scanning calorimetry. The transformation kinetics can be analyzed by means of the Avrami plot based on the Johnson-Mehl-Avrami equation.The kinetics of solid state reactions in the nanostructured material can be investigated similarly. Formation of a Ni-phase in a nanostructured Hf-Ni alloy could be detected in a very early stage, where calorimetric methods are not sensitive. Segregation phenomena could be detected from the experiments even after long time. The sensitivity of the applied method is not dependent on the heating rate as the sensitivity of scanning calorimetry | Reinhard L■ck(Max-Planck-Institut fur Metallforschung, Institut fur Werkstoffwissechaft,Seestraβe 75,D-70174 Stuttgart, Germany) | 1997 | Journal of Materials Science & Technology1997，13，4： | 0 |
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