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| 1 | Predictive findings forHelicobacter pylori-uninfected, -infected and -eradicated gastric mucosa: Validation study显示文摘AIM:To validate the usefulness of screening endoscopy findings for predictingHelicobacter pylori (H. pylori) infection status. METHODS:H. pylori infection status was determined by histology, serology, and the urea breast test in 77 consecutive patients who underwent upper endoscopy. Based on the findings, patients were categorized as H. pylori -uninfected, -infected, or -eradicated cases. Using six photos of certain sites in the stomach per case, we determined the presence or absence of the following endoscopic findings:regular arrangement of collecting venules (RAC), linear erythema, hemorrhage, fundic gland polyp (FGP), atrophic change, rugal hyperplasia, edema, spotty erythema, exudate, xanthoma, and mottled patchy erythema (MPE). The diagnostic odds ratio (DOR) and inter-observer agreement (Kappa value) for these 11 endoscopic findings used in the determination of H. pylori infection status were calculated. RESULTS:Of the 77 patients [32 men and 45 women; mean age (SD), 39.7 (13.4) years] assessed, 28 were H. pylori uninfected, 28 were infected, and 21 were eradicated. DOR values were significantly high (< 0.05) for the following H. pylori cases:uninfected cases with RAC (11.5), linear erythema (24.5), hemorrhage (4.1), and FGP (34.5); for infected cases with atrophic change (8.67), rugal hyperplasia (15.8), edema (14.2), spotty erythema (11.5), and exudate (3.52); and for eradicated cases with atrophic change (32.4) and MPE (103.0). Kappa values were excellent for FGP (0.93), good for RAC (0.63), hemorrhage (0.79), atrophic change (0.74), and MPE (0.75), moderate for linear erythema (0.51), rugal hyperplasia (0.49), edema (0.58), spotty erythema (0.47), and exudate (0.46), and poor for xanthoma (0.19). CONCLUSION:The endoscopic findings of RAC, hemorrhage, FGP, atrophic change, and MPE will be useful for predicting H. pylori infection status. | Kazuhiro Watanabe Naoyoshi Nagata Ryo Nakashima Etsuko Furuhata Takuro Shimbo Masao Kobayakawa Toshiyuki Sakurai Koh Imbe Ryota Niikura Chizu Yokoi Junichi Akiyama Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，27： | 17 |
| 2 | Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer显示文摘AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice variants.METHODS:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by immunohistochemistry.The association between VEGF-A expression status and clinicopathological factors was investigated.Twenty freshfrozen samples were obtained for laser capture microdissection to analyze the splice variants of VEGF-A.RESULTS:VEGF-A was expressed in 53.9% and 42.4% of tumor and stromal cells,respectively.VEGF-A expression in tumor cells(t-VEGF-A) was associated with advanced clinical stage(stage 0,1/9;stage 1,2/16;stage 2,32/55;stage 3,38/66;stage 4,16/19,P < 0.0001).VEGF-A expression in stromal cells(s-VEGF-A) increased in the earlier clinical stage(stage 0,7/9;stage 1,6/16;stage 2,33/55;stage 3,22/66;stage 4,5/19;P = 0.004).Multivariate analyses for risk factors of recurrence showed that only s-VEGF-A expression was an independent risk factor for recurrence(relative risk 0.309,95% confidence interval 0.141-0.676,P = 0.0033).The five-year disease-free survival(DFS) rates of t-VEGF-A-positive and-negative cases were 51.4% and 62.9%,respectively.There was no significant difference in t-VEGF-A expression status.The five-year DFS rates of s-VEGF-A-positive and-negative cases were 73.8% and 39.9%,respectively.s-VEGFA-positive cases had significantly better survival than s-VEGF-A-negative cases(P = 0.0005).Splice variant analysis revealed that t-VEGF-A was mainly composed of VEGF165 and that s-VEGF-A included both VEGF165 and VEGF165b.In cases with no venous invasion(v0),the level of VEGF165b mRNA was significantly higher(v0 204.5 ± 122.7,v1 32.5 ± 36.7,v2 2.1 ± 1.7,P = 0.03).The microvessel density tended to be lower in cases with higher VEGF165b mRNA levels.CONCLUSION:s-VEGF-A appears be a good prognostic factor for colorectal cancer and includes VEGF165 and VEGF165b. | Makoto Tayama Tomohisa Furuhata Yoshiko Inafuku Kenji Okita Toshihiko Nishidate Toru Mizuguchi Yasutoshi Kimura Koichi Hirata | 2011 | World Journal of Gastroenterology2011，17，44： | 10 |
| 3 | Feasibility and safety of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors, including esophagogastric junction tumors显示文摘 | Shu Hoteya Shusuke Haruta Hisashi Shinohara Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Toshifumi Mitani Osamu Ogawa Akira Matsui Toshiro Iizuka Harushi Udagawa Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，4： | 4 |
| 4 | Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Determining Tumor Invasion Depth in Early Gastric Cancer显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Sumio Watanabe Mitsuru Kaise Guido Schumacher | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 5 | Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes显示文摘 | Shu Hoteya Naohisa Yahagi Toshiro Iizuka Daisuke Kikuchi Toshifumi Mitani Akira Matsui Osamu Ogawa Satoshi Yamashita Tsukasa Furuhata Akihiro Yamada Ryusuke Kimura Kosuke Nomura Yasutaka Kuribayashi Mitsuru Kaise | 2013 | EIO2013，，01： | 2 |
| 6 | Delayed bleeding after endoscopic submucosal dissection for non‐ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors显示文摘 | Shu Hoteya Mitsuru Kaise Toshiro Iizuka Osamu Ogawa Toshifumi Mitani Akira Matsui Daisuke Kikuchi Tsukasa Furuhata Satoshi Yamashita Akihiro Yamada Ryusuke Kimura Kousuke Nomura Yasutaka Kuribayashi Yoshifumi Miyata Naohisa Yahagi | 2015 | Digestive Endoscopy2015，，3： | 2 |
| 7 | Isolation of a novel GPI-anchored gene specifically regulated by p53;correlation between its expression and anti-cancer drug sensitivity 显示文摘 | Furuhata T Toldno T Urano T | 1996 | Oncogene1996，13，9： | 1 |
| 8 | Application of ther- apeutic insonation to malignant gliomacells and facilitation by echo - contrast microbubbles of Levovist 显示文摘 | Manome Y Furuhata H Hashimoto A | 2009 | Anticancer Research2009，29，： | 1 |
| 9 | GML sensitizes cancer cells to Taxol by induction of apoptosis显示文摘 | r Kimura Y Furuhata T Shiratsuchi T et aI | 1997 | Oncogene1997，5，11： | 1 |
| 10 | Design and testing of the organic Rankine cycle显示文摘 | Yamamoto T Furuhata T Arai N | 2001 | Energy2001，26，3： | 1 |
| 11 | 查看详情显示文摘 | Matsuura T Miyamoto T Kageyama T Ohta M Matsui Y Furuhata T Koyama F | | 0，，： | 1 |
| 12 | Identification of chemical structure of antibacterial components anainst Lenionella paeumphi- la in a coffee beverage显示文摘 | Donasaki C Shindo T Furuhata K | 2002 | Ynaeugaku Znsshi2002，122，： | 1 |
| 13 | Formation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model 显示文摘 | Kawai Y Furuhata A Toyokuni S | 2003 | Journal of Biological Chimestry2003，278，50： | 1 |
| 14 | Relationship between the pressure and diameter of the carotid artery in humans显示文摘 | Sugawara M Niki K Furuhata H | 2000 | Heart Vessels2000，15，1： | 1 |
| 15 | Decreased GlcNAc 6-O-sulfotransferase activity in the cornea with macular corneal dystrophy显示文摘 | Hasegawa N Torii T Kato T Miyajima H Furuhata A Nakayasu K | 2000 | Invest Ophthalmol Vis sci2000，41，12： | 1 |
| 16 | Relationship between the pressure and diameter of the carotid artery in humans 显示文摘 | Sugawara M Niki K Furuhata H | 2000 | Heart and Vessels2000，15，4： | 1 |
| 17 | Design and testing of the organic Rankine cycle显示文摘 | Takahisa Yamamoto Tomohiko Furuhata | 2001 | Energy2001，26，3： | 1 |
| 18 | Pharmacokinetics of S -1 显示文摘 | Hirata K Horikoshi N Furuhata T | 2006 | Gan To Kagaku Ryoho2006，331，： | 1 |
| 19 | p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation显示文摘 | A. Furuhata A. Kimura K. Shide K. Shimoda M. Murakami H. Ito S. Gao K. Yoshida Y. Tagawa K. Hagiwara A. Takagi T. Kojima M. Suzuki A. Abe T. Naoe T. Murate | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 20 | Vascular, endothelial growth factor C promotes gastric carcinoma lymph node metastasis in mice 显示文摘 | Yanai Y Furuhata T Ktmura Y | 2001 | J Exp Clin Cancer Res2001，20，： | 1 |
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