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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 3 | 高应变区裂纹尖端张开位移COD表达式显示文摘根据工程构件常呈现局部高应变梯度的特征而不是全面屈服状态的事实,本文提出了高应变区中LiCOD表达式。将其与从Dugdale-Muskhelivili模型导得的低应力范围内的COD表达式相结合,即可得到全部应力应变范围内的COD表达式。作者设计了两种SCT试样,试验结果表明:在很大的应力应变范围内,该表达式计算值与试验数据相符。试验还证明:SCT试样成功地再现了实际工程构件(如压力容器接管)高应变梯度区的特征,且不再出现宽板标定曲线的COD冻结等奇异现象,从而证明该表达式可以应用于工程结构。 | 李泽震 Solomos G Lucia A Volta G | 1989 | 压力容器1989，6，5： | 3 |
| 4 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 5 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 6 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | LUCIA R V DARIO G L EMANUELA P | 2007 | Nature2007，445，： | 1 |
| 7 | Quantitative analysis of 2-furfural and 5-methyl furfural in different Italian vinegars by headspace solid-phase microextraetion coupled to gas chromatography mass spectrometry using isotope dilution 显示文摘 | G Lucia R Calabrese | 2003 | Journal of Chromatography A2003，1017，： | 1 |
| 8 | Pharyngeal airway vol- ume and shape from cone--beam computed tomography-- re- lationship to facial morphology 显示文摘 | Dan G Lucia SH Martin A | 2009 | Am J Orthod Dentofacial Orthop2009，136，6： | 1 |
| 9 | Microbiological effects of acid decontamination of pork carcasses at various locations in processing 显示文摘 | PRASAI R K ACUFF G R LUCIA L M | 1992 | Meat Science1992，32，4： | 1 |
| 10 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 11 | ACE gene polymorphism and insulin action in older subjects and healthy centenarians显示文摘 | Paolisso G Tagliamonte MR De Lucia D | 2001 | J Am Geriatr Soc2001，49，： | 1 |
| 12 | New insights into lignin modification during chlorine dioxide bleaching sequences ( Ⅰ ) : Chlorine dioxide delignifieation显示文摘 | BROGDON B N MANCOSKY D G LUCIA L A | 2005 | Journal of Wood Chemistry and Technology2005，24，3： | 1 |
| 13 | Determination of bisphenol A and bisphenol B residues in canned peeled tomatoes by reversed-phase liquid chromatography显示文摘 | LUCIA G DOMENICO M SERENELLA S | 2008 | J Agric Food Chem2008，56，10： | 1 |
| 14 | Transformation of maltose into prebiotic isomaltooligosaccharides by a novela-glucosidase from Xantophyllomyces dendrorhous 显示文摘 | Lucia F A Dolores M Aranzazu G | 2007 | Process Biochemistry2007，42，： | 1 |
| 15 | Occurrence of trichothecene mycotoxins in Brazilian corn-based food products显示文摘 | THAIS V M LUCIA M V BAPTISTA G G | 2006 | Food Control2006，17，： | 1 |
| 16 | 2 Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alphastimulated gene 6 显示文摘 | Garcia G E Wisniewski H G Lucia M S | 2006 | Clin Cancer Res2006，12，31： | 1 |
| 17 | Bone cemen textracts modulate the osteoprotegerin/osteoprotegerin ligand expressionin MG63 osteoblast-like cells显示文摘 | Donatella G Elisabetta C Lucia S | 2002 | Biomaterials2002，23，15： | 1 |
| 18 | Hormone Research显示文摘 | Chicharro J L Hoyos J Bandres F Gallego F G Perez M Lucia A | 2001 | 55(3):1552001，55，3： | 1 |
| 19 | Effect of different land use on soil erosion in the pre-alpine fringe (North-East Italy):ion budget and sediment yield显示文摘 | Claudio B Serena G Lucia Z | 2006 | Science of Total Environment2006，369，： | 1 |
| 20 | Trocar site hernia after lapamscopic ventral hernia repair显示文摘 | Boldo' E Perez de Lucia G Aracil JP | 2007 | Sung Endosc2007，21，5： | 1 |
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