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| 1 | Gene Expression Versus Sequence for Predicting Function: Glia Maturation Factor Gamma Is Not A Glia Maturation Factor显示文摘It is standard practice, whenever a researcher finds a new gene, to search databases for genes that have a similar sequence. It is not standard practice, whenever a researcher finds a new gene, to search for genes that have similar expression (coexpression). Failure to perform co-expression searches has lead to incorrect conclusions about the likely function of new genes, and has lead to wasted laboratory attempts to confirm functions incorrectly predicted. We present here the example of Glia Maturation Factor gamma (GMF-gamma). Despite its name, it has not been shown to participate in glia maturation. It is a gene of unknown function that is similar in sequence to GMF-beta. The sequence homology and chromosomal location led to an unsuccessful search for GMF-gamma mutations in glioma.We examined GMF-gamma expression in 1432 human cDNA libraries. Highest expression occurs in phagocytic, antigen-presenting and other hematopoietic cells.We found GMF-gamma mRNA in almost every tissue examined, with expression in nervous tissue no higher than in any other tissue. Our evidence indicates that GMF-gamma participates in phagocytosis in antigen presenting cells. Searches for genes with similar sequences should be supplemented with searches for genes with similar expression to avoid incorrect predictions. | Michael G.Walker | 2003 | Genomics, Proteomics & Bioinformatics2003，1，1： | 1 |
| 2 | A LONGITUDINAL EXAMINATION OF CONCOMITANT CHANGES IN TEAM LEADERSHIP AND CUSTOMER SATISFACTION显示文摘 | ALAN G.WALKER JAMES W.SMITHER DAVID A.WALDMAN | 2008 | Personnel Psychology2008，，3： | 1 |
| 3 | Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence显示文摘 | S. W.Bell K. G.Walker M. J. F. X.Rickard G.Sinclair O. F.Dent P. H.Chapuis E. L.Bokey | 2003 | Br J Surg2003，，10： | 1 |
| 4 | Psychological distress and visual functioning in relation to vision‐related disability in older individuals with cataracts显示文摘 | J. G.Walker K. J.Anstey S. R.Lord | 2010 | British Journal of Health Psychology2010，，2： | 1 |
| 5 | A LONGITUDINAL EXAMINATION OF CONCOMITANT CHANGES IN TEAM LEADERSHIP AND CUSTOMER SATISFACTION显示文摘 | ALAN G.WALKER JAMES W.SMITHER DAVID A.WALDMAN | 2008 | Personnel Psychology2008，，3： | 1 |
| 6 | 碳酸盐造岩矿物中Mn^2+中心的发光光谱显示文摘在室温和77K条件下测定了方解石、白云石、菱镁矿、锰方解石和菱锰矿中Mn^2+的阴极发光发射谱和光激发谱。根据激发谱计算了配位场参数以反映被Mn^2+占据的金属离子晶格的大小。光激发谱技术可以分别确定白云石中Mg和Ca格点上Mn^2+的吸收分布。通过简单的模式阐明和讨论了白云石中Mg和Ca格点之间Mn^2+分布变化的规律。结论表明,白云石中Mn^2+的分布能够很好地提供关于形成条件及后来蚀变情况的资料。 | G.Walker 覃建雄 等 | 1991 | 国外地质(成都)1991，0，2： | 0 |
| 7 | 大型斯特林低温冷却器的设计原则显示文摘斯特林机可用作从高温热源吸热而发出动力的原动机,或从低温吸热在高温放热而耗功的制冷机和热泵。 | G.Walker 周立平 周志舰 | 1985 | 低温与特气1985，3，1： | 0 |
| 8 | 光前放接收机的噪声与灵敏度(Ⅰ):理论显示文摘光前置放大器在强度调制——直接检测(IMDD)系统中的应用,使常规的IMDD系统灵敏度接近了同类外差接收机的指标,而在系统可靠性、稳定性和成本等方面则优于外差接收系统。本文从理论上分析了IMDD系统光前放接收机的噪声和灵敏度特性,给出了具体计算公式。这些计算公式均以系统元部件可测参数来表示,因此对实际的系统设计和性能评价有重大实用价值。 | 杨淑雯 姚建国 N.Walker G.Walker R.Steel | 1993 | 深圳大学学报(理工版)1993，10，1： | 0 |
| 9 | Are Gene Expression Microarray Analyses Reliable? A Review of Studies of Retinoic Acid Responsive Genes显示文摘Microarray analyses of gene expression are widely used, but reports of the same analyses by different groups give widely divergent results, and raise questions regarding reproducibility and reliability. We take as an example recent published reports on microarray experiments that were designed to identify retinoic acid responsive genes. These reports show substantial differences in their results. In this article, we review the methodology, results, and potential causes of differences in these applications of microarrays. Finally, we suggest practices to improve the reliability and reproducibility of microarray experiments. | Peter J.van der Spek Andreas Kremer Lynn Murry Michael G.Walker | 2003 | Genomics, Proteomics & Bioinformatics2003，1，1： | 0 |
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