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| 1 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Effective Determination of Mobile Agent Itineraries for Data Aggregation on Sensor Networks显示文摘 | Konstantopoulos C Mpitziopoulos A Gavalas D | 2010 | IEEE Transactions on Knowledge and Data Engineering2010，22，12： | 1 |
| 3 | Inhibition of rennin-angiotensin system and advanced glycation end products formation:a promising therapeutic approach targeting on cardiovascular diseases显示文摘 | Geronikaki A Gavalas A Dislian V | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，： | 1 |
| 4 | Intraoarticle Mass Transfer in Coal Pyrolysis 显示文摘 | Gavalas G R Wilks K A | 1980 | AIChE1980，26，2： | 1 |
| 5 | Anterior Hox genes interact with components of the neural crest specification network to induce neu- ral crest fates 显示文摘 | Gouti M Briscoe J Gavalas A | 2011 | Stem Cells2011，29，5： | 1 |
| 6 | Retinoid signaling and hindbrain patterning显示文摘 | Gavalas A Krumlauf R | 2000 | Curt Opin Genet Dev2000，10，： | 1 |
| 7 | JAID: An algorithm for data fusion and jamming avoidance on distributed sensor networks 显示文摘 | MPITZIOPOULOS A GAVALAS D KONSTANTOPOULOS C | 2009 | Pervasive and Mobile Computing2009，5，2： | 1 |
| 8 | Analysis of the chicken GPAT/AIRC bidirectional promoter for de novo pu rine nucleotide synthesis显示文摘 | GAVALAS A ZALKIN H | 1995 | J Biol Chem1995，270，5： | 1 |
| 9 | Fullerene- mediated amperometricbiosensors显示文摘 | Gavalas V G Chaniotakis N A | 2000 | Anal Chim Acta2000，409，： | 1 |
| 10 | Polyelectrolyte stabilized oxidase based biosensors: effect of diethylaminoethyl - dextran on the stabilization of glucose and lactate oxidases into porous conductive carbon显示文摘 | Gavalas V G Chaniotakis N A | 2000 | Anal Chim Acta2000，404，： | 1 |
| 11 | Analysis of the Chicken GPAT/AIRC Bidirectional Promoter for de Novo Purine Nucleotide Synthesis 显示文摘 | GAVALAS A ZALKIN H | 1995 | Journal of Biological Chemis- try1995，270，5： | 1 |
| 12 | Phosphate biosensor based on polyelectrolyte -stabilized pyruvate oxidase 显示文摘 | Gavalas V G Chaniotakis N A | 2001 | Anal Chim Acta2001，427，： | 1 |
| 13 | Nutritional evaluation and bioactive microconstituents (carotenoids, tocopherols, sterols and squalene ) of raw and roasted chicken fed on DHA-rich microalgae 显示文摘 | Kalogeropoulos N Chiou A Gavala E | 2010 | Food Research International2010，43，8： | 1 |
| 14 | Effective determination of mobile agent itineraries for data aggregation on sensor networks 显示文摘 | KONSTANTOPOULOS C MPIZIOPOULOS A GAVALAS D | 2010 | Knowledge and Data Engineering IEEE Transactions on2010，22，12： | 1 |
| 15 | An approach for near-optimal distributed data fusion in wireless sensor networks显示文摘 | GAVALAS D MPIZIOPOULOS A PANTZIOU G | 2010 | Wireless Networks2010，16，5： | 1 |
| 16 | Autoimmunity as an aetiological factor in vitiligo 显示文摘 | Rezaei N Gavalas N G Weetman A P | 2007 | J Eur Acad Dermatol Venereol2007，21，7： | 1 |
| 17 | Neuronal defects in the hindbrain of Hoxa1,Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes显示文摘 | Gavalas A Ruhrberg C Livet J | 2003 | Development2003，130，： | 1 |
| 18 | Inhibition of renin - angiotensin system and advanced glycation end products formation: a promising therapeutic approach targeting on cardiovascular diseases 显示文摘 | Geronikaki A Gavalas A Dislian V | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，4： | 1 |
| 19 | Polyelectrolyte stabilized oxidase based biosensor: effect of diethylaminoethy- dextran on the stabilization of glucose and lactate oxidase into porous conductive carbon显示文摘 | GAVALAS V G CHANIOTAKIS N A | 2000 | Analytica Chimica Acta2000，404，： | 1 |
| 20 | Inhibition of rennin - angiotensin system and advanced glycation end products formation : a promising therapeutic approach targeting on cardiovascular diseases显示文摘 | Geronikaki A Gavalas A Dislian V | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，： | 1 |
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