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| 1 | Identification of Ubiquitinated Proteins from Human Multiple Myeloma U266 Cells by Proteomics显示文摘Objective To identify ubiquitinated proteins from complex human multiple myeloma (MM) U266 cells,a malignant disorder of differentiated human B cells.Methods Employing a globally proteomic strategy combining of immunoprecipitation,LC-MS/MS and SCX-LC-MS analysis to identified ubiquitination sites,which were identified by detecting signature peptides containing a GG-tag (114.1 Da) and an LRGG-tag (383.2 Da).Results In total,52 ubiquitinated proteins containing 73 ubiquitination sites of which 14 and 59 sites contained LRGG-tag and GG-tag were identified,respectively.Conclusion Classification analysis by of the proteins identified in the study based on the PANTHER showed that they were associated with multiple functional groups.This suggested the involvement of many endogenous proteins in the ubiquitination in MM. | JIA HongLing LIU ChaoWu GE Feng XIAO ChuanLe LU ChunHua WANG Tong HE QingYu | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 2 | Aberrant microRNA expression in the development of breast carcinoma显示文摘microRNAs,a class of small non-coding regulatory RNAs,are involved in oncogenesis and cancer development.Studies have shown that aberrant miRNA expression occurs in breast cancer and is associated with specific clinicopathological features.Some miRNAs might act as suppressor genes or oncogenes,which can be considered as novel markers for breast cancer diagnosis and as prognostic factors.Here we present a review of recent discoveries on miRNAs involved in breast cancer tumorigenesis,invasion,and metastasis. | WU Qian LI HaiLing LU JiaFeng GE QingYu LU ZuHong | 2010 | Chinese Science Bulletin2010，55，31： | 0 |
| 3 | Recent advances in directα-C(sp^(3))-H bond functionalization of thioethers显示文摘Thioether skeletons are widely present in drugs,natural products,functional materials,and life science.In the past decade,the selective C–H functionalization of thioethers has been extensively studied to construct novel thioether derivatives.This mini-review systematically introduces the recent advances in the field of the directα-C(sp^(3))-H functionalization of thioethers. | Long Tang Qingyue Hu Ke Yang Mazen Elsaid Chong Liu Haibo Ge | 2022 | Green Synthesis and Catalysis2022，3，3： | 0 |
| 4 | Iron acquisition by Streptococcus species: An updated review显示文摘Streptococcus is a genus of spherical Gram-positive bacteria responsible for many cases of meningitis,bacterial pneumonia, endocarditis, erysipelas, and necro-tizing fasciitis. To survive in the host environment withlimited free iron available, Streptococcus species havedeveloped various mechanisms to uptake iron as anessential nutrient. They can directly extract the metalions from host iron-containing proteins such as ferritin,transferrin, lactoferrin, and hemoproteins. Other iron-uptake strategies, which are broadly distributed in thestrains, include the employment of specialized secretedhemophores to acquire heme and the usage of smallmolecules called siderophores as high-affinity ferricchelators. This review intends to discuss the most recentdiscoveries of these iron acquisition systems and theirrelevant regulators in Streptococcus species. | Ruiguang GE Xuesong SUN Qingyu HE | 2009 | Frontiers in Biology2009，4，4： | 0 |
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