|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs显示文摘This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in combination,on growth performance,antioxidation,inflammation and intestinal function of weaned pigs.One hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per pen.Dietary treatments included the following:1)control diet(CON),2)CON with 300 mg/kg essential oils(EO),3)CON with 500 mg/kg protease(PRO),4)CON with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for sampling.The remaining pigs were fed for an additional week and growth performance was monitored during this period.Dietary treatments had no marked effects(P>0.05)on the growth performance of pigs.However,pigs receiving EO diet had higher(P<0.05)serumglutathione peroxidase(GSH-Px)activity,and tended to decrease(P=0.063)serum concentration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(P<0.05)abundances of phylum Actinobacteria,and genera Bifidobacterium,and lower(P<0.05)phylum Bacteroidetes and genera Alloprevotella in colonic digesta.Pigs receiving PRO diet decreased(P<0.05)the serum concentration of malondialdehyde(MDA)and diamine oxidase activity,increased(P<0.05)the villus height and the ratio of villus height to crypt depth in duodenum,increased sucrase activity in jejunal mucosa,and also increased the abundance of phylum Actinobacteria in colonic digesta.Furthermore,the synergistic effects of EO and PROwas observed(P<0.05)for pigs with decreasing serum TNF-a concentration and increasing serum GSH-Px activity.Collectively,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned pigs.EO diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on reducing inflammatory parameters in weaned pigs. | Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che | 2022 | Animal Nutrition2022，，2： | 8 |
| 2 | Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function显示文摘Background: Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is hypothesized to correlate with changes in the glutathione(GSH)redox system. Therefore, these parameters were simultaneously measured throughout the weaning phase, in piglets differing in birth weight category and weaning age, as these pre-weaning factors are important determinants for the weaning transition. Low birth weight(LBW) and normal birth weight(NBW) littermates were assigned to one of three weaning treatments;i.e. weaning at 3 weeks of age(3 w), weaning at 4 weeks of age(4 w) and removal from the sow at 3 d of age and fed a milk replacer until weaning at 3 weeks of age(3 d3 w). For each of these treatments, six LBW and six NBW piglets were euthanized at 0, 2, 5, 12 or 28 d post-weaning piglets, adding up 180 piglets.Results: Weaning increased the glutathione peroxidase activity on d 5 post-weaning in plasma, and duodenal and jejunal mucosa. Small intestinal glutathione-S-transferase activity gradually increased until d 12 post-weaning, and this was combined with a progressive rise of mucosal GSH up till d 12 post-weaning. Oxidation of the GSH redox status(GSH/GSSG Eh) was only observed in the small intestinal mucosa of 3 d3 w weaned piglets at d 5 postweaning. These piglets also demonstrated increased fluorescein isothiocyanate dextran(FD4) and horseradish peroxidase fluxes in the duodenum and distal jejunum during the experiment, and specifically demonstrated increased FD4 fluxes at d 2 to d 5 post-weaning. On the other hand, profound villus atrophy was observed during the weaning transition for all weaning treatments. Finally, LBW and NBW piglets did not demonstrate notable differences in GSH redox status, small intestinal barrier function and histo-morphology throughout the experiment.Conclusion: Although moderate changes in the GSH redox system were observed upon weaning, the GSH redox status remained at a steady state level in 3 w and 4 w weaned piglets and was therefore not associated with weaning induced villus atrophy. Conversely, 3 d3 w weaned piglets demonstrated GSH redox imbalance in the small intestinal mucosa, and this co-occurred with a temporal malfunction of their intestinal barrier function. | Jeroen Degroote Hans Vergauwen Wei Wang Chris Van Ginneken Stefaan De Smet Joris Michiels | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 2 |
| 3 | Artificial rearing influences the morphology,permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets显示文摘Background: In this study the physiological implications of artificial rearing were investigated. Low(LBW) and normal birth weight(NBW) piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW piglets from 16 litters suckled the sow until d19 of age or were artificially reared starting at d3 until d19 of age. Blood and tissue samples that were collected after euthanasia at 0, 3, 5, 8 and 19 d of age. Histology, ELISA, and Ussing chamber analysis were used to study proximal and distal small intestine histomorphology, proliferation, apoptosis, tight junction protein expression, and permeability. Furthermore, small intestine,liver and systemic redox parameters(GSH, GSSG, GSH-Px and MDA) were investigated using HPLC.Results: LBW and NBW artificially reared piglets weighed respectively 40 and 33% more than LBW and NBW sowreared piglets at d19(P < 0.01). Transferring piglets to a nursery at d3 resulted in villus atrophy, increased intestinal FD-4 and HRP permeability and elevated GSSG/GSH ratio in the distal small intestine at d5(P < 0.05). GSH concentrations in the proximal small intestine remained stable, while they decreased in the liver(P < 0.05). From d5 until d19, villus width and crypt depth increased, whereas PCNA, caspase-3, occludin and claudin-3 protein expressions were reduced. GSH,GSSG and permeability recovered in artificially reared piglets(P < 0.05).Conclusion: The results suggest that artificial rearing altered the morphology, permeability and redox state without compromising piglet performance. The observed effects were not depending on birth weight. | Hans Vergauwen Jeroen Degroote Sara Prims Wei Wang Erik Fransen Stefaan De Smet Christophe Casteleyn Steven Van Cruchten Joris Michiels Chris Van Ginneken | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 2 |
| 4 | Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials 显示文摘 | VERKERK A O VAN GINNEKEN A C BERECKI G | 2006 | Cardiovasc Res2006，70，3： | 1 |
| 5 | Automatic segmentation of pulmonary segments from volumetric chest CT scans 显示文摘 | Van Rikxoort E M de Hoop B van de Vorst S ProkopM van Ginneken B | 2009 | Medical Imaging IEEE Transactions on2009，28，4： | 1 |
| 6 | Information fusion for diabetic retinopathy CAD in digital color fundus photographs显示文摘 | Niemeijer M Abra'moff M D van Ginneken B | 2009 | IEEE Tran Med Imaging2009，28，5： | 1 |
| 7 | Remote monitoring of implantable cardioverter defibrillator patients: a safe, time-saving, and cost-effective means for follow-up显示文摘 | Raatikainen MJ Uusimaa P van Ginneken MM | 2008 | Europaee2008，10，10： | 1 |
| 8 | Gardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube显示文摘 | Fijnvandraat AC van Ginneken AC de Boer PA | 2003 | Cardiovasc Res2003，58，2： | 1 |
| 9 | The Netherlands:Health system review显示文摘 | Sch fer W Kroneman M Boerma W van den Berg M Westert G Devill é W and van Ginneken E | | 0，，01： | 1 |
| 10 | Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes 显示文摘 | Verkerk AO van Ginneken AC van Veen TA | 2007 | Europace2007，9，8： | 1 |
| 11 | Comparison and evaluation of methods for liver segmentation from CT datasets 显示文摘 | HEIMANN T GINNEKEN B MARTIN A | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 12 | Automatic segmentation of hmg fields in chest radiographs 显示文摘 | Ginneken B V Romeny B 3' H | 2000 | MedPhys2000，27，10： | 1 |
| 13 | Distribution of atrial and nodal cells within rabbit sinoatrial node :models of sinoatrialtransition显示文摘 | Verheijck EE Wessels A van Ginneken AC et aft | 1998 | Circu lation1998，97，16： | 1 |
| 14 | Remote monitoring of implantable cardioverter defibrillator patients : a safe, time-saving, and cost-effective means for follow-up 显示文摘 | Raatikainen MJ Uusimaa P van Ginneken MM | 2008 | Europace2008，10，10： | 1 |
| 15 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner M A | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 16 | Effects of a rehabilitation programme on daily functioning, participation, health-related quality of life, anxiety and depression in liver transplant recipients显示文摘 | B.T.J. Van Ginneken H.J.G. Van Den Berg-emons H.J. Metselaar H.W. Tilanus G. Kazemier H.J. Stam | 2010 | Disability & Rehabilitation2010，，25： | 1 |
| 17 | Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocar,dium显示文摘 | Fijmvandraat AC van Ginneken AC Schumacher CA | 2003 | Md Cell Cardiol2003，35，12： | 1 |
| 18 | Fast detection of the optic disc and fovea in color fundus photographs显示文摘 | NIEMEIJER M ABRMOFF M D VAN GINNEKEN B | 2009 | Medical Image Analysis2009，13，6： | 1 |
| 19 | Mutation in the KCNQ1 gene leading to the short QT-interval syndrome显示文摘 | Bellocq C van Ginneken ACC Bezzina CR | 2004 | Circulation2004，109，： | 1 |
| 20 | A computer-aided diagnosis system for detection of lung nodules in chest radiographs with an evaluation on a public database显示文摘 | Schitham AMR van Ginneken B Loog M | 2006 | Medical Image Analysis2006，10，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员