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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | 针灸科研需解决的问题显示文摘指出针灸科研需要解决的问题。到目前为止,针灸还没有合适的对照:假性针灸并不是非常有别于真性针灸;安慰剂针灸由于针的压力可能引发机械刺激,会导致疼痛传导,另外可能与影响神经系统的化学物质效应相关。对照安慰剂的随机临床试验由于缺乏没有任何操作的对照而很难实施,因此,发现针灸的作用以建立合适的对照尤其重要。应该重视与传统治疗(药物等)对照的针灸试验,以证明哪些疾病采用针灸治疗具有无副作用且费用低廉的优势。 | Carlo Maria Giovanardi | 2011 | 南京中医药大学学报2011，27，4： | 3 |
| 3 | US-elastography in the differential diagnosis of benign and malignant thyroid nodules 显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，5： | 1 |
| 4 | US - elastography in the differential diagnosis of benign and malignant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，5： | 1 |
| 5 | Ischemic Preconditioning Protects the Pig Liver by Preserving the Mitochondrial Structure and Downregulating Caspase-3 Activity显示文摘 | Rafael Omar Giovanardi Ernani Luis Rhoden Carlos Thadeu Cerski Miriam Salvador Antonio Nocchi Kalil | 2009 | Investigative Surgery2009，，2： | 1 |
| 6 | Uelastog- raphy in the differential diagnosis of benign and malig- nant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，5： | 1 |
| 7 | US-elastography in the differ-ential diagnosis of benign and malignant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，5： | 1 |
| 8 | Glomerular filtration rates in HIV-infeeted patients treated with and without tenofovir: a prospective, observational study显示文摘 | Guaraldi G Roverato A Giovanardi C | 2009 | J Antimicrob Chemother2009，63，2： | 1 |
| 9 | US-Elastography in the differential diagnosis of benign and maligrtant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A et a l | 2008 | Thyroid2008，18，5： | 1 |
| 10 | Corrosion resistance of HVOF-sprayed coatings for hard chrome replacement 显示文摘 | Bolelli G Giovanardi R Lusvarghi L | 2006 | Corrosion Science2006，，48： | 1 |
| 11 | Tailored preoperative treatment of locally advanced triple negative(hormone receptor negative and HER2negative)breast cancer with epirubicin,cisplatin,and infusional fluorouracil followed by weekly paclitaxel显示文摘 | Torrisi R Balduzzi A Ghisini R Rocca A Bottiglieri L Giovanardi F | 2008 | Cancer Chemother Pharmacol2008，62，4： | 1 |
| 12 | US - elastogra- phy in the differential diagnosis of benign and malignant thy- roidnodules 显示文摘 | Asteria C Giovanardi A Pizzocaro A etal | 2008 | Thyroid2008，18，5： | 1 |
| 13 | US-elastography in tial diagnosis of benign and malignant thyroid nodules 显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，： | 1 |
| 14 | US-elastography in the differential diagnosis of benign and malignant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A | | 0，，： | 1 |
| 15 | A new environmentally friendly process for the recovery of gold from electronic waste显示文摘 | Luisa Barbieri Roberto Giovanardi Isabella Lancellotti Marco Michelazzi | | Environmental Chemistry Letters0，，： | 1 |
| 16 | Ambulatory measurement of shoulder and elbow kinematics through inertial and magnetic sensors显示文摘 | CUTTI A G GIOVANARDI A ROCCHI L | 2008 | Medical and Biological Engineering and Computing2008，46，16： | 1 |
| 17 | US-elastography in the differential diagnosis of benign and malignant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzoearo A | 2008 | Thyroid2008，18，5： | 1 |
| 18 | Corrosion Resistance of HVOF- sprayed Coatings for Hard Chrome Replacement 显示文摘 | Bolelli G Giovanardi R | 2008 | Corrosion Science2008，48，： | 1 |
| 19 | US-elastography in the differential diagnosis of begnign and malignant thyroid nodules显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，： | 1 |
| 20 | US elastography in the differential diagnosis of' benign and malignant thyroid nodules 显示文摘 | Asteria C Giovanardi A Pizzocaro A | 2008 | Thyroid2008，18，： | 1 |
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