|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 2 | A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B显示文摘 | CHANG T T GISH R G DE MAN R | 2006 | N Engl J Med2006，354，： | 1 |
| 3 | Bcr-Abl oncoproteins binddirectly toactivators of the Ras signalling pathway显示文摘 | Puil L Liu J Gish G | 1994 | EMBO J1994，13，4： | 1 |
| 4 | A comparison of Entecavir and lamivtldine for HBeAg-positive chronic Hepatitis B显示文摘 | Chang T T Gish R G Man R D | 2006 | N Engl Med2006，354，10： | 1 |
| 5 | Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype显示文摘 | Kunath T Gish G Lickert H | 2003 | Nat Biotechnol2003，21，： | 1 |
| 6 | Sustained response off-treatment to entecavir and lamivudine after 48 weeks of treatment in nucleoside-naYve, HBeAg+ patients : 24-week follow-up results of phase 3 study ETV-022 显示文摘 | GISH R G DE MAN R A PEDERSEN C | 2005 | J Hepatol2005，42，2： | 1 |
| 7 | A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B 显示文摘 | CHANG T T GISH R G DE MAN R | 2006 | N Engl J Med2006，354，10： | 1 |
| 8 | A Comparison of entecavir and lamivudine for HBeAgpositive chronic hepatitis B显示文摘 | Chang T T Gish R G de Man R | 2006 | N Engl J Med2006，354，10： | 1 |
| 9 | The discoidin domain receptor tyrosine kinases are actived by collagen显示文摘 | Vogel W Gish G Aires C | 1997 | Mol Cell1997，1，1： | 1 |
| 10 | Bcr-Abl oncoproteins bind directly to activators of the Ras signaling pathway显示文摘 | Pull L Liu J Gish G | 1994 | EMBO J1994，13，4： | 1 |
| 11 | Emecavir therapy for up to 96 weeks in patients wish, HBeAg-positive chronic hepatititis B显示文摘 | Gish R G Lok A S Chang T T et el | 2007 | Gastroenterplogy2007，133，5： | 1 |
| 12 | Primary biliary cirrhosis in monozygotic and dizygotic twins:genetics,epigeneties,and environment显示文摘 | Selmi C Mayo M J Bach N Ishibashi H Invernizzi P Gish R G | 2004 | Gastroenterology2004，127，： | 1 |
| 13 | Thunderstorms and the earth's general electrification 显示文摘 | Gish O H Wait G R | 1950 | Journal of Geophysical Research1950，55，4： | 1 |
| 14 | Transgenic RNA interference in ES cellderived embryos recapitulates a genetic null phenotype 显示文摘 | Kunath T Gish G Lickert H | 2003 | Nat Biotechnol2003，21，5： | 1 |
| 15 | A multidisciplinary approachto the management of hepatocellular carcinoma 显示文摘 | Gish R G Marrero J A Benson A B | 2010 | GastroenterolHepatol (N Y)2010，6，3： | 1 |
| 16 | Transgenic RNA interference in ES cell-derived embryonic recapitulates a genetic null phenotype 显示文摘 | KWNATH T GISH G LICKERT H | 2003 | Nat Biotechnol2003，21，5： | 1 |
| 17 | Bcr-abl oncoproteins bind directly to activators of the Ras signalling pathway显示文摘 | Puil L Liu J Gish G | | 0，，04： | 1 |
| 18 | Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide显示文摘 | Pascal S M Singer A U Gish G | 1994 | Cell1994，77，3： | 1 |
| 19 | Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway显示文摘 | Puil L Liu J Gish G | 1994 | EMBO J1994，13，4： | 1 |
| 20 | A randomized, douhlehlind comparison of 3 doses of emtrieitabine in patients with chronic hepatitis B given 48 weeks of treatment显示文摘 | LEUNG N GISH R G WANG C | 2001 | Hepatology2001，34，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员