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| 1 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 2 | Endothelial nitric oxide synthasegene polymorphism as a possible risk factor inaneurysmal subarachnoid haemorrhage显示文摘 | Ozum U Bolat N Gul E | 2008 | Acta Neurochir (Wien)2008，150，1： | 1 |
| 3 | Discretionary-accruals models and audit qualifications显示文摘 | Bartov E Gul F Tsui J | 2000 | Journal of Accounting and Economics2000，30，3： | 1 |
| 4 | Changes in smile parameters asperceived by orthodontists, dentists, artists, and laypeople显示文摘 | Gul -e -Erum Fida M | 2008 | World J Orthod2008，9，2： | 1 |
| 5 | Discretionary-accruals models and audit qualifications显示文摘 | BARTOV E GUL F A TSUI J S L | 2000 | Journal of Accounting and Economics2000，30，3： | 1 |
| 6 | Conspiciousconsumption patterns of Turkish youth : case of celluarphones显示文摘 | AEIKALIN S GUL E DKVELIOGLU K | 2009 | Young Consumers2009，10，3： | 1 |
| 7 | Thrombolysis in patients with pulmonary embolism and elevated heart-type fatty acid-binding protein levels显示文摘 | Gul E E Can I Kayrak M | 2014 | J Thromb Thrombolysis2014，37，4： | 1 |
| 8 | THE EFFICACY OF DOPPLER ULTRASOUND ON CHRONIC SUPPURATIVE OT1TIS MEDIA显示文摘 | Gul A Akdag M Ozkurt F E | 2015 | Acta Medica Mediterranea2015，31，1： | 1 |
| 9 | Inflammatory pseudotumor of the kidney: a case report 显示文摘 | Tarhan F Gul A E Karadayi N | 2004 | Int Urol Nephrol2004，36，2： | 1 |
| 10 | Discretionary-Accruals Model and Audit Qualifications 显示文摘 | Bartov E Gul F A Tsui J S | 2001 | Journal of Accounting and Economics2001，30，03： | 1 |
| 11 | Analyzing power disturb-ances using the residuals of AR models 显示文摘 | Gul Y H Styvaktakis E Bollen M H J | 2000 | IEEE Power Engi-neering Review2000，20，4： | 1 |
| 12 | Comparison of hysterosalpingography and laparoscopy in the evaluation of infertile women显示文摘 | Sakar M N Gul T Atay A E | 2008 | SaudiMedJ2008，29，9： | 1 |
| 13 | Nanons: a nanoscale network simulator famework for molecular communications显示文摘 | GUL E ATAKAN B AKAN O | 2010 | Nano Com- munication Networks2010，1，2： | 1 |
| 14 | Prophylactic balloon occlusion of the common iliae arteries for the management of suspected placenta acere- ta/percreta : conclusions from a short case series 显示文摘 | Minas V Gul N Shaw E | 2014 | Arch Gynecol2014，291，2： | 1 |
| 15 | Differentiation of be- nign and malignant cervical lymph nodes: value of B-mode and color Doppler sonography 显示文摘 | Adibelli ZH Unal G Gul E | 1998 | Eur J Radiol1998，28，3： | 1 |
| 16 | Dermatological findings in the senior population of nursing homes in Turkey 显示文摘 | Kilic A Gul U Aslan E | 2008 | Arch Gerontol Geriatr2008，47，1： | 1 |
| 17 | Laaksonen, et al, Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin - induced diabetic rats 显示文摘 | Mustafa Gul David E | 2002 | Scandinavian Journal of Medicine & Science in Sports2002，12，3： | 1 |
| 18 | The efficiency ofproanthocyanidin in an experimental pulmonary fibrosis model:comparison with taurine 显示文摘 | Agackiran Y Gul H Gunay E | 2012 | Inflammation2012，35，4： | 1 |
| 19 | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at in- termediate risk 显示文摘 | GUL E E CAN I GULER I | 2012 | Diagnostic and Interventional Radiology2012，18，6： | 1 |
| 20 | Index of myocardial performance in pa- tients with type 2 diabetes without hypertension and its relationship with clinical and echocardiographic parameters显示文摘 | Saglam H Seyfeli E Gul I | 2009 | J Diabetes2009，1，1： | 1 |
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