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| 1 | Measurement and Analysis of Formation Conditions of Dew in Carex lasiocarpa Marsh显示文摘In order to investigate the dew amounts and analysis formation conditions of dew by examining the correlations between dew amounts and meteorological factors in Carex lasiocarpa marsh in the Sanjiang Plain,the dew amounts and several meteorological factors were monitored during the growing season from June to September in 2005 and 2008 at the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences.Dew was collected by woodstick made by poplar tree in Carex lasiocarpa marsh and the amounts were estimated by subtraction method.The results indicated that average daily accumulated dew amounts reached the peak in August.The highest dew amounts in Carex lasiocarpa marsh were 0.201 mm/d,and the most frequent dew volume ranged from 0.08 mm/d to 0.14 mm/d.The amounts correlated positively with relative humidity,dew point temperature,and water vapor pressure.Whereas it correlated negatively with wind speed.The dew production in Carex lasiocarpa marsh more frequently occurred under the conditions of wind speed around 2.0 m/s,the water vapor pressure above 9 hPa;the relative humidity between 90% and 95% and dew point temperature above 6 ℃. | XU Yingying YAN Baixing GUO Yuedong | 2009 | 湿地科学2009，7，2： | 6 |
| 2 | Dynamics of dissolved organic carbon in the mires in the Sanjiang Plain,Northeast China显示文摘Mires in boreal area had proved to be an important dissolved organic carbon (DOC) reserve for the sensitivity to climate change and human interfering. The study was focused on the temporal and spatial dynamics and controlling factors of DOC in a seasonally-waterlogged mire (SLM) and perennially-waterlogged mire (PLM) in the Sanjiang Plain, Northest China. In the two mires, DOC concentrations in both surface water and upper soil strata experienced pronounced seasonal variation. DOC concentrations in the surface waters were the greatest and averagely was 47.82 in SLM and 34.84 mg/L and PLM, whereas that in soil water at 0.3-m depth had little difference (20.25 mg/L in SLM and 26.51 mg/L in PLM). Results revealed that DOC concentrations declined 5-8 times vertically from the surface down to groundwater. DOC in the groundwater only was in a very small part with the average concentration of 5.18 mg/L. In relation to the surface water, DOC concentrations varied positively with temperature just before 8 August, and only in early spring and later autumn DOC concentrations exhibited identifiable spatial trends along with standing water depths in PLM. It was supposed that the influences from standing water depth took effect only in conditions of low temperature, and temperature should be the most powerful factor controlling DOC dynamics in the mires. Redox potential (Red) showed negative relationship with DOC values while total nitrogen (TN) and the majority of free ions in the soil solution exhibited no relationship. High soil TOC/TN ratio and low redox potentials also led to DOC accumulation in the mires in the Sanjiang Plain. | Yuedong Guo Zhongmei Wan Deyan Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 5 |
| 3 | Diagenesis-Mineralization and Ore Prospecting of the Yangla Copper Deposit, Yunnan Province, Southwest China显示文摘The large-scale Yangla copper deposit,located in the central part of the Sanjiang Tethys polymetallic belt,is structurally controlled by the Jinsha River Fault and Yangla Fault.This deposit consists of seven ore blocks,including the Beiwu,Nilv,Jiangbian,Linong,Lunong, | LI Bo HUANG Zhilong ZHOU Jiaxi ZOU Guofu TANG Guo LIU Yuedong | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 4 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 5 | Nanocatalytic bacteria disintegration reverses immunosuppression of colorectal cancer显示文摘Tumor-associated bacteria(TAB)play a critically important role in regulating the microenvironment of a tumor,which consequently greatly deteriorates the therapeutic effects by chemo-and radiotherapy deactivation and,more considerably,leads to substantial immunosuppression.On the contrary,herein we propose a nanocatalytic tumor-immunotherapeutic modality based on the bacteria disintegration by bacteria-specific oxidative damage under magnetic hyperthermia for highly effective immune response activation-promoted tumor regression.A monodispersed and superparamagnetic nanocatalytic medicine modified by arginyl-glycyl-aspartic acid(RGD)and(3-carboxypropyl)triphenylphosphonium bromide(TPP),named as MNP-RGD-TPP herein,has been synthesized,which features selective accumulation at the TAB by the electrostatic affinity,enabling effective TAB disintegration by the nanocatalytic Fenton reaction producing abundant cytotoxic hydroxyl radicals in situ under alternating magnetic field-induced hyperthermia.More importantly,the lipopolysaccharide has been metabolically secreted from the destructed TAB as pathogen-associated molecular patterns(PAMPs)to M1-polarize tumor-associated macrophages(TAMs)and promote the maturation of dendritic cells(DCs)for innate immuno-response activation of TAMs,followed by cytotoxic T lymphocytes awakening under the PAMPs presentation by the mature DCs against tumor cells.The integrated innate and adaptive immunity activations based on this TAB-promoted nanocatalytic immunomedicine,instead of magnetic heating-induced hyperthermia or the released Fe2+/Fe3+Fenton agent,has been found to achieve excellent therapeutic efficacy in an orthotopic colorectal cancer model,demonstrating the great potential of such an integrated immunity strategy in clinical tumor immunotherapy. | Han Jiang Yuedong Guo Zhiguo Yu Ping Hu Jianlin Shi | 2022 | National Science Review2022，9，11： | 1 |
| 6 | Power and energy management of grid/PEMFC/batter- y/supercapacitor hybrid power sources for UPS appli- cations显示文摘 | ZHAN Yuedong GUO Youguang ZHU Jianguo | 2015 | Electrical Power and Energy Systems2015，67，： | 1 |
| 7 | Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma显示文摘Gastric carcinoma (GC) progression is mainly caused by local aggression and lymph node metastasis. However, some patients with early T-stage disease have lymph node metastasis, whereas some patients with late T-stage disease do not have lymph node metastasis, which indicates that invasion and metastasis are not always sequential in some GC patients. In the present study, the data of 101 GC cases were acquired from TCGA and divided into T-late-N-negative and T-early-N-positive groups according to pathological stages. A total of 338 genes were identified as differential genes between the T-late-N-negative and T-early-N-positive groups. GSEA showed that epithelial cell signaling in the Helicobacter pylori (HP ) infection pathway was enriched in the T-early-N-positive group. MB staining indicated that the HP infection rate was 63% (39/62) in N-positive patients compared to 42% (16/38) in N-negative patients. To investigate the potential mechanism, we focused on the gene chemokine (C-X-C motif) receptor 2 (CXCR2), which was not only clustered in the gene set of epithelial cells signaling in the HP infection pathway but also significantly upregulated in T-early-N-positive GC by the analysis of the different genes based on the TCGA dataset. A meta-analysis showed that CXCR2 expression was positively correlated with N-stage but not with T-stage in GC. This study indicated that invasion and metastasis could be independent processes driven by different molecular mechanisms in some GC patients. HP infection was a potential factor that promoted lymph node metastasis by upregulating CXCR2 expression. | Lang Zha Xiong Guo Xiaolong Liang Yuedong Chen Deyong Gan Wenwen Li Ziwei Wang Hongyu Zhang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 8 | Nanomedicine-Leveraged Intratumoral Coordination and Redox Reactions of Dopamine for Tumor-Specific Chemotherapy显示文摘Great efforts have been made in investigating the neurotoxicity of dopamine(DA)in the presence of manganous ions.In contrast,here,we probe the possibility of DA-based cancer chemotherapy by leveraging intratumoral redox reactions of DA for producing cytotoxic species in situ.For this purpose,we have constructed a Mn-engineered,DA-loaded nanomedicine.Based on the unique size effect of the nanocarrier,this nanomedicine will not enter the central nervous system but can effectively accumulate in the tumor region,after which the nanocarrier can degrade to release Mn^(2+)and DA in response to the mild acidic intracelluar microenvironment of cancer cells.DA can chelate Mn^(2+)to form a binary coordination complex,where the strong metal-ligand interaction significantly promotes electron delocalization and elevates the reducibility of Mn center,favoring two sequential one-electron oxygen reduction reactions forming H_(2)O_(2),which can be further converted into highly oxidizing ·OH under the cocatalysis by Mn^(2+)and intracellular Fe^(2+).Additionally,as a twoelectron oxidation product of DA ligand,DA-oquinone is potent in exhausting cellular sulfhydryl and depleting reduced glutathione,inhibiting the intrinsic antioxidative mechanism of cancer cells,finally triggering severe oxidative damages in a synergistic manner.It is expected that such a strategy of nanotechnology-mediated metal-ligand coordination and subsequent nontoxicity-to-toxicity transition of DA in tumor may provide a promising prospect for future chemotherapy design. | Bowen Yang Yuedong Guo Yuemei Wang Jiacai Yang Heliang Yao Jianlin Shi | 2022 | CCS Chemistry2022，4，5： | 0 |
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