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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Thyroid function tests in non-alcoholic cirrhotic patients with hepatic encephalopathy 显示文摘 | Guven K Keletimur F Yucesoy M | 1993 | Eur J Med1993，2，： | 1 |
| 3 | The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning显示文摘 | Guven M Sungur M Eser B | 2004 | J Toxicol Clin Toxicol2004，42，5： | 1 |
| 4 | The use of screw at the frac- ture level in the treatment of thoracolumbar burst fractures 显示文摘 | Guven O Kocaoglu B Bezer M | 2009 | J Spinal Disord Tech2009，22，6： | 1 |
| 5 | Urolithiasis in the first year of life显示文摘 | Guven AG Koyun M Baysal YE | 2010 | Pediatr Nephrol2010，25，1： | 1 |
| 6 | The use of screw at the fracture level in the treatment of thoracolumbar burst fractures显示文摘 | Guven O Kocaoglu B Bezer M | | 0，，： | 1 |
| 7 | The use of screw at the fracture level in the treatment of thoracolumbar burst fractures显示文摘 | Guven O Kocaoglu B Bezer M | | 0，，06： | 1 |
| 8 | Congestion-driven transmission planning considering the impact of generator expansion显示文摘 | Tor O B Guven A N Shahidehpour M | | 0，，02： | 1 |
| 9 | Autologous fat augmen- tation for voice and swallow improvement after cordectomy 显示文摘 | Guven M Suoglu Y Kiyak E | 2006 | ORL J Otorhinolaryngol Relat Spec2006，68，： | 1 |
| 10 | The use of screw at the fracture level in the treatment of thoracolumbar burst fractures显示文摘 | Guven O Kocaoglu B Bezer M | 2009 | J Spinal Disord Tech2009，22，6： | 1 |
| 11 | Influence of starters on chemical, biochemical,and sensory changes in Turkish White-Brined Cheese during ripening显示文摘 | Hayalogu A A Guven M Fox P F | 2005 | Journal of Dairy Science2005，，10： | 1 |
| 12 | Protective effeets of chronic melatonin treatmenr against renal injury in streptozo- tocin- induced diabetic rats显示文摘 | Cam M Yavuz O Guven F | 2003 | J Pineal Res2003，35，3： | 1 |
| 13 | A new current model flux observer for wide speed range sensorless control of an induction machine 显示文摘 | Rehman H Derdiyok A Guven M K XU Longya | 2002 | IEEE Trans on P E2002，17，6： | 1 |
| 14 | The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep ap-nea显示文摘 | GUVEN S F TURKKANI M H CIFTCI B | 2012 | Sleep Breath2012，16，： | 1 |
| 15 | The use of screw at the frac- ture level in the treatment of thoraeolumbar burst fractures 显示文摘 | Guven O Kocaoglu B Bezer M | 2009 | J Spinal Disord Tech2009，22，6： | 1 |
| 16 | Totally tubeless percutaneous nephrolithotomy:is it safe and effective in preschool Children?显示文摘 | Ozturk A Guven S Kilinc M | 2010 | J Endourol2010，5，24： | 1 |
| 17 | Correlation between posteromedial or postemlateral displacement and cubitus varus deformity in supraeondylar humerus fractures in children显示文摘 | EREN A GUVEN M EROL B | 2008 | J Child Orthop2008，2，2： | 1 |
| 18 | Intensive care management of organophosphate insecticide poisoning 显示文摘 | Sungur M Guven M | 2001 | Crit Care2001，5，4： | 1 |
| 19 | The use of screw at the fracture level in the treatment of thoracolumbar burst fractures 显示文摘 | Guven O Kocaoglu B Bezer M | 2009 | JSpinal Disord Tech2009，22，6： | 1 |
| 20 | Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus显示文摘 | Guven MA Kilinc M Batukan C | 2006 | Arch Gynecol Obstet2006，274，6： | 1 |
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