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| 1 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Thrombogenic and atherogenic activities of lysophosphatidic acid显示文摘 | Wolfgang S Gabor T | 2004 | J Biol Chem2004，92，6： | 1 |
| 3 | Surface shading in the cuberille environment 显示文摘 | Chen L S Gabor T H | 1985 | IEEE Computer Graphics and Application1985，5，12： | 1 |
| 4 | Comparison of depositional sequences and tectonic styles among the West African deep- water frontiers of western Ivory Coast,southern Equatorial Guinea and northern Namibia显示文摘 | Katrina C Gabor C T Molnar J | 2002 | The Leading Edge2002，10，： | 1 |
| 5 | 查看详情显示文摘 | Gabor N M Song J Ma Q Nair N L Taychatanapat T Watanabe K Taniguchi T Levitov L S Jarillo-Herrero P | | 0，，： | 1 |
| 6 | Fractal dimension estimations of drainage network in the Carpathian-Pannonian system显示文摘 | ENDRE D GABOR T GABOR B | 2007 | Global and Planetary Change2007，58，： | 1 |
| 7 | Understanding delta-sigma data converters显示文摘 | RICHARD S GABOR C T | 2006 | IEEE Circuits and Devices Magazine2006，22，4： | 1 |
| 8 | The reaction of carbethoxymethylenetriphenylphosphorane with ketones显示文摘 | GABOR F ISTVAN T | 1961 | Tetrahedrola Lett1961，16，16： | 1 |
| 9 | Minimizing RO energy consumption under variable conditions of operation 显示文摘 | Manth T Gabor M Oklejas E | 2003 | Desalination2003，157，13： | 1 |
| 10 | Impact of nocturnalhemodialysis on the variability of heart rate and duration ofhypoxemia during sleep 显示文摘 | CHAN C T HANLY P GABOR J | 2004 | Kidney Int2004，65，2： | 1 |
| 11 | The Assessment of Community Vulnerability to Acute Hazardous Materials Incidents显示文摘 | Gabor T Griffith T K | 1980 | Journal of Hazardous Materials1980，8，1： | 1 |
| 12 | Influence of a TiO2 buffer layer on the magnetic properties of anatase Co: TiO2 thin films 显示文摘 | Gabor M S Petrisor T Tiusan C | 2012 | JAppl Phys2012，111，08： | 1 |
| 13 | Immo bilization of collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa ) with Telazol and xylazine 显示文摘 | GABOR T M HELLGREN E C SILVY N J | 1997 | J Wildl Dis1997，33，1： | 1 |
| 14 | Chiral separation by a monofuncticnalized cyclodextrin derivative: From selector to permethyl-β- cyclodextrin bonded stationary phase显示文摘 | GABOR V GABOR T K KRISZTINA N | 2010 | Pharm Biomed Anal2010，51，： | 1 |
| 15 | Expression of Transient Receptor Potential C6 Channels in Human Lung Macrophages显示文摘 | Finney-Hayward Tricia K Popa Mariana Oana Bahra Parmjit Li Su Poll Christopher T Gosling Martin Nicholson Andrew G Russell Richard E K Kon Onn Min Jarai Gabor Westwick John Barnes Peter J Donnelly Louise E | 2010 | American Journal of Respiratory Cell and Molecular Biology2010，，3： | 1 |
| 16 | The efficacy of ECT treatment in depression: a meta-analysis显示文摘 | Gabor G Laszl6 T | 2005 | Psychiatr Hung2005，20，3： | 1 |
| 17 | A comparison of established and new approaches in ovine and bovine nuclear transfer 显示文摘 | Teijat T Penra T T Gabor V | 2003 | Cloning and Stem Cells2003，4，： | 1 |
| 18 | An ecologically-based method for selecting ecological indicators for assessing risks to biological diversity from genetically-engineered plants显示文摘The environmental risks associated with genetically-engineered( GE) organisms have been controversial,and so have the models for the assessment of these risks. We propose an ecologically-based environmental risk assessment( ERA) model that follows the 1998 USEPA guidelines,focusing on potential adverse effects to biological diversity. The approach starts by( 1) identifying the local environmental values so the ERA addresses specific concerns associated with local biological diversity. The model simplifies the indicator endpoint selection problem by( 2) classifying biological diversity into ecological functional groups and selecting those that deliver the identified environmental values.( 3) All of the species or ecosystem processes related to the selected functional groups are identified and( 4) multi-criteria decision analysis( MCDA) is used to rank the indicator endpoint entities,which may be species or ecological processes. MCDA focuses on those species and processes that are critical for the identified ecological functions and are likely to be highly exposed to the GE organism. The highest ranked indicator entities are selected for the next step.( 5) Relevant risk hypotheses are identified. Knowledge about the specific transgene and its possible environmental effects in other countries can be used to assist development of risk hypotheses.( 6) The risk hypotheses are ranked using MCDA with criteria related to the severity of the potential risk. The model emphasizes transparent,expert-driven,ecologically-based decision-making and provides formal methods for completing a screening level-ERA that can focus ERA on the most significant concerns. The process requires substantial human input but the human capital is available in most countries and regions of the world. | D.A.Andow Gabor L.Lvei Salvatore Arpaia Lewis Wilson Eliana M.G.Fontes Angelika Hilbeck Andreas Lang Nguyên Vǎn Tu't C.S.S.Pires E.R.Sujii Claudia Zwahlen A.N.E.Birch Deise M.F.Capalbo Kristina Prescott Celso Omoto Adam R.Zeilinger | 2013 | 生物安全学报2013，22，3： | 1 |
| 19 | Complex phytohormone responses during the cold acclimation of two wheat cultivars differing in cold tolerance, winter Samanta and spring Sandra显示文摘 | Klára Kosová Ilja Tom Prá?il Pavel Vítámvás Petre Dobrev Václav Motyka Kristyna Floková Ond?ej Novák Veronika Ture?ková Jakub Rol?ik Bed?ich Pe?ek Alena Trávni?ková Alena Gaudinová Gabor Galiba Tibor Janda Eva Vlasáková Pavla Prá?ilová Radomíra Vanková | | Journal of Plant Physiology0，，： | 1 |
| 20 | Herman and abraham naparstek, fast image reconstruction based on a formula appropriate for rapidly collected data显示文摘 | Gabor T | 1977 | SIAM Journal on Appli1977，33，： | 1 |
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