4篇
您的检索式：作者名="Gabriel Ferrer"
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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Drag reduction via turbulent boundary layer flow control显示文摘Turbulent boundary layer control(TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational-simulation capabilities,which have improved the understanding of the flow structures of turbulence.Advances in micro-electronic technology have enabled the fabrication of active device systems able to manipulating these structures.The combination of simulation,understanding and micro-actuation technologies offers new opportunities to significantly decrease drag,and by doing so,to increase fuel efficiency of future aircraft.The literature review that follows shows that the application of active control turbulent skin-friction drag reduction is considered of prime importance by industry,even though it is still at a low technology readiness level(TRL).This review presents the state of the art of different technologies oriented to the active and passive control for turbulent skin-friction drag reduction and contributes to the improvement of these technologies. | ABBAS Adel BUGEDA Gabriel FERRER Esteban FU Song PERIAUX Jacques PONS-PRATS Jordi VALERO Eusebio ZHENG Yao | 2017 | Science China(Technological Sciences)2017，60，9： | 4 |
| 3 | Numerical modeling of cracking pattern's influence on the dynamic response of thickened tailings disposals: a periodic approach显示文摘Copper production is an essential component of the Chilean economy. During the extraction process of copper, large quantities of waste materials(tailings) are produced, which are typically stored in large tailing ponds. Thickened Tailings Disposal(TTD) is an alternative to conventional tailings ponds. In TTD, a considerable amount of water is extracted from the tailings before their deposition. Once a thickened tailings layer is deposited, it loses water and it shrinks, forming a relatively regular structure of tailings blocks with vertical cracks in between, which are then filled up with 'fresh' tailings once the new upper layer is deposited. The dynamic response of a representative column of this complex structure made out of tailings blocks with softer material in between was analyzed using a periodic half-space finite element model. The tailings' behavior was modeled using an elasto-plastic multi-yielding constitutive model, and Chilean earthquake records were used for the seismic analyses. Special attention was given to the liquefaction potential evaluation of TTD. | Gabriel Ferrer Esteban Sáez Christian Ledezma | 2018 | Earthquake Engineering and Engineering Vibration2018，17，1： | 1 |
| 4 | Contemporary comparison of aortic arch repair by endovascular and open surgical reconstructions显示文摘 | Paola De Rango Ciro Ferrer Carlo Coscarella Francesco Musumeci Fabio Verzini Gabriele Pogany Andrea Montalto Piergiorgio Cao | 2014 | Journal of Vascular Surgery2014，，： | 1 |
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