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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 3 | Seismic tomography imaging of an unstable embankment 显示文摘 | GIAN P D GAETANO R | 2005 | Engineering Geology2005，82，1： | 1 |
| 4 | Nerve growth factor in- duces angiogenic activity in a mouse model of hindlimb ischemia 显示文摘 | Turrini P Gaetano C Antonelli A | 2002 | Neurosci Lett2002，323，： | 1 |
| 5 | A Framework for User Experi- ence, Needs and Affordanees显示文摘 | FRANCESCO P GAETANO C | 2014 | Design Studies2014，35，2： | 1 |
| 6 | Brain cancer immunoediting:novel examples provided by immunotherapy of malignant gliomas显示文摘 | Serena P Lucia C Gaetano F | | 0，，11： | 1 |
| 7 | Prognostic value of the metabolic syndrome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coll Cardiol2004，43，10： | 1 |
| 8 | Manipulation of the blue light photoreceptor cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content显示文摘 | Leonardo G Gaetano P Patrizia P | 2005 | Plant Physiology2005，137，： | 1 |
| 9 | Prognostic value of the metabolic syn- drome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coil Cardio12004，43，： | 1 |
| 10 | Primary sphenoid esthesioneuroblastoma studied with MR显示文摘 | Gaetano C Stefano P Silvio M | 2003 | J Clin Imaging2003，27，1： | 1 |
| 11 | Use of T-wave altemans in identifying patients with coronary artery disease 显示文摘 | Stefano F Alessandra S Gaetano P | 2014 | Cardiovas- cular Medicine2014，10，： | 1 |
| 12 | Fixed Investment and Economic Growth: New Results On Causality 显示文摘 | Elena P Gaetano C | 2001 | Applied Economics2001，，33： | 1 |
| 13 | A detailed analysis of power-supply noise attenuation in bandgap voltage references 显示文摘 | GIANLUCA G GAETANO P | 2003 | IEEE Trans Cire and Syst2003，50，2： | 1 |
| 14 | Latest developments in gene transfer technology: Achievements, perspectives, and controversies over therapeutic applications显示文摘 | Gaetano R Pietro M Carmen P | 2000 | Stem Cells2000，18，1： | 1 |
| 15 | Prognostic value of the metabolic syndrome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 16 | Prognostic value of the metabolic syndrome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coll Cardiol2004，43，10： | 1 |
| 17 | Nerve growth factor induces angiogenic activity in a mouse model of hindlimb ischemia显示文摘 | Turrini P Gaetano C Antonel i A | | 0，，02： | 1 |
| 18 | Sonographic patterns of the gallbladder in acute viral hepatitis 显示文摘 | Maresca G Gaetano A D Mirk P | 1984 | J Clin Ultrasound1984，12，3： | 1 |
| 19 | Nerve growth factor induces angiogenic activity in a mouse model of hindlimb ischemia显示文摘 | Turrini P Gaetano C | 2002 | Neumsei Lett2002，323，： | 1 |
| 20 | Stress,social support,emotional regulation,and exacerbation of diffuse plaque psoriasis显示文摘 | Picardi A Mazzotti E Gaetano P | | 0，，06： | 1 |
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