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| 1 | Herbal Medicine in Ischemic Stroke:Challenges and Prospective显示文摘Herbal medicines, mainly of plant source, are invaluable source for the discovery of new therapeutic agents for all sorts of human ailments. The complex pathogenesis of stroke and multifactorial effect of herbal medicine and their active constituents may suggest the promising future of natural medicine for stroke treatment. Anti-oxidant, anti-inflammatory, anti-apoptotic, neuroprotective and vascular protective effect of herbal medicines are believed to be efficacious in stroke treatment. Herbs typically have fewer reported side effects than allopathic medicine, and may be safer to use over longer period of time. Herbal medicines are believed to be more effective for the longstanding health complaints, such as stroke. Several medicinal plants and their active constituents show the promising results in laboratory research. However failure in transformation of laboratory animal research to the clinical trials has created huge challenge for the use of herbal medicine in stroke. Until and unless scientifically comprehensive evidence of the efficacy and safety of herbal medicine in ischemic stroke patients is available, efforts should be made to continue implementing treatment strategies of proven effectiveness. More consideration should be paid to natural compounds that can have extensive therapeutic time windows, perfect pharmacological targets with few side effects. Herbal medicine has excellent prospective for the treatment of ischemic stroke, but a lot of effort should be invested to transform the success of animal research to human use. | Bhakta Prasad Gaire | 2018 | Chinese Journal of Integrative Medicine2018，24，4： | 13 |
| 2 | Scutellaria baicalensis in Stroke Management:Nature's Blessing in Traditional Eastern Medicine显示文摘Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern medicine,especially in Chinese medicine.The major phytochemicals isolated from S.baicalensis are flavonoids,glycosides and their glucoronides such as baicalin,baicalein,wogonin etc.More than 30 different kinds of flavonoids are isolated from this plant.S.baicalensis and its flavonoids are reported to have several pharmacological activities,which includes anti-allergic,antioxidant,anti apoptic,anti-inflammatory effects and many more.Recently,S.baicalensis and its isolated flavonoids have been studied for their neuroprotective effects,through a variety of in vitro and in vivo models of neurodegenerative diseases,plausibly suggesting that S.baicalensis has salutary effect as a nature's blessing for neuroprotection.In this review,we are focousing on the neuroprotective effects of S.baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death.We aimed at compiling all the information regarding the neuroprotective effect of S.baicalensis in various experimental models of cerebral ischemia or stroke. | Bhakta Prasad Gaire Sang-Kwan Moon Hocheol Kim | 2014 | Chinese Journal of Integrative Medicine2014，20，9： | 8 |
| 3 | A review on the pharmacological and toxicological aspects of Datura stramonium L.显示文摘Datura stramonium L., a wild-growing plant of the Solanaceae family, is widely distributed and easily accessible. It contains a variety of toxic tropane alkaloids such as atropine, hyoscamine, and scopolamine. In Eastern medicine, especially in Ayurvedic medicine, D. stramonium has been used for curing various human ailments, including ulcers, wounds, inflammation, rheumatism and gout, sciatica, bruises and swellings, fever, asthma and bronchitis, and toothache. A few previous studies have reported on the pharmacological effects of D. stramonium; however, complete information regarding the pharmacology, toxicity, ethnobotany and phytochemistry remains unclear. Ethnomedicinally, the frequent recreational abuse of D. stramonium has resulted in toxic syndromes. D. stramonium, in the form of paste or solution to relieve the local pain, may not have a deleterious effect; however, oral and systemic administration may lead to severe anticholinergic symptoms. For this reason, it is very important for individuals, mainly young people, to be aware of the toxic nature and potential risks associated with the use of this plant. This comprehensive review of D. stramonium includes information on botany, phytochemistry, pharmacology, toxicology and ethnomedicinal uses. | Bhakta Prasad Gaire Lalita Subedi | 2013 | Journal of Integrative Medicine2013，11，2： | 5 |
| 4 | 青藏高原东缘两处高山树线交错带时空动态及其建群种的生态学特征显示文摘热量匮乏是高山树线的主要成因,在全球变暖趋势下对高山树线及其建群种的生态学过程及特征的研究具有重要意义。该文以青藏高原东缘的折多山和剪子弯山两处高山树线(海拔分别为4 265 m和4 425 m)作为研究对象,通过设置垂直样带,同时结合区域温度、降水的长时间序列分析,探究两处树线的时空动态过程,并明确了建群种冷杉(Abies spp.)的生态学特征。结果表明:1)折多山和剪子弯山区域的气温在过去58年均存在显著的上升趋势(分别上升了0.72和0.91℃),而折多山和剪子弯山区域降水均存在微弱的降低趋势。2)折多山的峨眉冷杉(A. fabri)龄级结构呈反J形,剪子弯山的鳞皮冷杉(A. squamata)龄级结构呈双峰形,二者种群结构均相对稳定。3)在小尺度上,种子扩散限制使得两处树线的冷杉聚集分布。在大尺度上,折多山峨眉冷杉亦呈聚集分布,而剪子弯山鳞皮冷杉受生长环境以及种内或种间关系的影响呈随机分布。4)两处样地建群树种的树高和基径均随海拔升高而降低,位于树线交错带上部的冷杉均呈现树高生长大于径向生长的异速生长关系,而位于样地中、下部位的冷杉大部分呈等速生长关系。5)相比10年前,折多山和剪子弯山的树线及树种线位置均无明显变化,剪子弯山鳞皮冷杉种群的树木密度亦无明显变化,而折多山的树木个体数提高了约25%;相比20年前,折多山和剪子弯山的树种线分别上移了50和30 m,树线位置分别升高了75和40 m,树木个体数亦明显增加,分别提高了约220%和100%。树线及其建群种在较大时空尺度上主要受热量的控制,而在较小时空尺度上受温度及生长环境共同作用的影响。 | 周天阳 NARAYAN Prasad Gaire 廖礼彬 郑莉莉 王金牛 孙建 魏彦强 谢雨 吴彦 | 2018 | 植物生态学报2018，42，11： | 3 |
| 5 | Neuroprotective effects of Fructus Chebulae extracts on experimental models of cerebral ischemia显示文摘OBJECTIVE:To investigate the neuroprotective effects of Fructus Chebulae extract using both in vivo and invitromodels of cerebral ischemia.METHODS:As an in vitro model,oxygen glucose deprivation followed by reoxygenation(OGD-R)and hydrogen peroxide(H2O2)induced cellular damage in rat pheochromocytoma(PC12)cells was used to investigate the neuroprotective effects of extract of Fructus Chebulae.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to calculate cell survival.For in vivo,occlusion of left middle cerebral artery on rats was carried out as a focal cerebral ischemic model.RESULTS:Fructus Chebulae extract increases the PC12 cell survival against OGD-R and H2O2by 68%and 91.4%respectively.Fructus Chebulae also de-creases the cerebral infarct volume by 39%and extent of hemisphere swelling from 17%in control group to 10%in FructusChebulaetreated group.CONCLUSION:Fructus Chebulae,as a traditional medicine,can rescue the neuronal cell death against ischemia related damage.The possible mechanism for the neuroprotection might be the inhibition of oxidative damages occurring after acute phase of cerebral ischemia. | Bhakta Prasad Gaire Hocheol Kim | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 2 |
| 6 | Normal visual development after unilateral complete ptosis at birth显示文摘 | Gair FJ Adams GG | 1999 | J AAPOS1999，3，1： | 1 |
| 7 | Dynamic model of a lead acid battery for use in a domestic fuel cell system 显示文摘 | DURR M CRUDEN A GAIR S | 2006 | Journal of Power Sources2006，161，2： | 1 |
| 8 | Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine显示文摘 | Williams G D Maan H Ramamoorthy C Kamra K Bratton S L gair E | 2010 | Paediatr Anaesth2010，20，： | 1 |
| 9 | Control of an EV Drive with Reduced Unsprung Mass显示文摘 | Hredzak B Gair S Eastham J F | 1998 | IEEE Transactions on Electric Power Applications1998，145，6： | 1 |
| 10 | Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat olgodendrocytes in culture:a model for studying neuropathy due to vitamin B12 deficiency显示文摘 | Sponne IE Gaire D Stabler SP | 2000 | J Neurosci Lett2000，288，： | 1 |
| 11 | Effects of the particle size of soil- less substrates upon AM fungus in oculum production 显示文摘 | ATO AMAV GAIR ALOK Adholcya | 2000 | Mycorrhiza2000，，10： | 1 |
| 12 | Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro显示文摘 | Danzeisen R Gair S | 2001 | Biochemical Journal2001，356，3： | 1 |
| 13 | The nine C-terminal residues of the grapevine fanleaf nepovirus movement protein are critieal for systemic viruss spread显示文摘 | BELIN SCHMITT C GAIRE F | 1999 | Journal of General Virol1999，80，13： | 1 |
| 14 | Dynamic model of a lead acid battery for use in a domestic fuel cell system 显示文摘 | DURR M CRUDEN A GAIR S | 2006 | Journal of Power Sources2006，161，： | 1 |
| 15 | Protein 2A of grapevine fanleaf Nepovirus is implieated in RNA2 replieation and coloealizes to the replieation site显示文摘 | GAIRE F SCHMITT C STUSSI-GARAUD C | 1999 | Virol1999，264，1： | 1 |
| 16 | Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium显示文摘 | Osteen KG Rodgers WH Gaire M | 1994 | Proc Natl Acad Sci U S A1994，91，10： | 1 |
| 17 | 兴都库什喜马拉雅地区高海拔树木生长对气候变化的响应显示文摘高海拔地区快速升温可能导致树木对温度响应更为敏感,而限制高海拔地区树木生长的关键气候因子以及气候变化对树木生长产生多大程度的影响尚不清楚。本研究在兴都库什喜马拉雅地区收集了73个样点的树轮数据,包括3个优势属的树种(Abies属、Juniperus属和Picea属),样点海拔均在3000 m以上。将时间动态规整(dynamic time warping)的方法用于建立亚区域年表,以考虑不同站点年表之间变化的同步性。同时,定量分析了气候因子对树木生长的贡献以及树木生长与气候因子关系的时空动态。研究结果发现,73个站点年表可以聚为3类,且与其所处的生物气候区相对应,即西喜马拉雅地区,中东喜马拉雅地区和藏东南地区。在干旱的西喜马拉雅地区,树木生长与冬、春两季的降水呈正相关关系,而在湿润的藏东南地区,树木生长与冬季温度和春季降水呈正相关关系。树木生长受最低温度的影响最大,特别是冬季温度,其重要性从西到东呈现递增趋势。滑动窗口相关分析表明,在中西喜马拉雅地区,影响树木生长的冬季温度信号在减弱,然而在藏东南地区该信号随着1980年以来的快速升温而增强。本研究结果表明,若该地区升温持续,在西喜马拉雅地区可能会因变暖引起的水分亏缺而造成森林衰退,而在藏东南地区因树木生长得益于变暖而使得森林扩张。 | Lili Zheng Narayan Prasad Gaire Peili Shi | 2021 | Journal of Plant Ecology2021，14，5： | 1 |
| 18 | Bit-interleaved coded modulation显示文摘 | GAIRE G TARICCO G BIGLIERI E | 1998 | IEEE Trans Inform Theory1998，44，3： | 1 |
| 19 | Sturucture and Expression of the human gene for the matrix metalloproteinase matrilysin显示文摘 | Gaire M Magbanua Z Mcdonel S | 1994 | J Biol Chem1994，270，2： | 1 |
| 20 | Structure and expression of the human gene for the matrix metalloproteinase matrilysin 显示文摘 | Gaire M Magbanua Z McDonnell S | 1994 | Biol Chem1994，269，3： | 1 |
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