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| 1 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 2 | Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | Galis ZS Johnson C Godin D | 2002 | Circ Res2002，91，9： | 1 |
| 3 | Targeted disruption of the matrix metalloproteinase-9 gene impairs muscle cell migration and geometrical arterial remodelling 显示文摘 | Galis ZS Johnson C Godin D | 2002 | Circ Res2002，91，9： | 1 |
| 4 | The role of matrix metallopro- teinase-2 in the remodeling of cell-seeded vascular constructs subjected to cyclic strain 显示文摘 | Seliktar D Nerem RM Galis ZS | 2001 | Ann Biomed Eng2001，29，11： | 1 |
| 5 | Positive pressure mechanical ventilation显示文摘 | GALI B GOYAL D G | 2003 | Emerg Med Clin North Am2003，21，2： | 1 |
| 6 | Kinetic and equilibrium mass-dependent isotope fractionation laws in nature and their geochemical and eosmochemieal significance显示文摘 | Young E D Galy A Nagahara H | 2002 | Geochimiea et Cosmochimica Acta2002，66，： | 1 |
| 7 | The isotope geochemistry and cosmochemistry of magnesium显示文摘 | Young E D Galy A | 2004 | Rev Mineral Geochem2004，55，1： | 1 |
| 8 | Transmural pressure induces matrix-degrading activity in porcine arteries ex vivo显示文摘 | CHESLER N C KU D N GALIS Z S | 1999 | Am J Physiol1999，277，： | 1 |
| 9 | Mesenehymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneie mice 显示文摘 | Galie M Konstantinidou G Peroni D | 2008 | Oneogene2008，27，18： | 1 |
| 10 | Systemic hypotension and decreased pressor re sponse in dogs with chronic bile duct ligation显示文摘 | Bomzon A Rosenberg M Gali D Binah O Mordechovitz D Better O S | 1986 | Hepatology 19861986，，： | 1 |
| 11 | Targeted disruption of the matrix metalioproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | Galis ZS Johnson C Godin D | 2002 | Circ Res2002，91，9： | 1 |
| 12 | Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation显示文摘 | Gali~d M Courvalin P Lambert T | 2003 | Antimicrob Agents Chemother2003，47，8： | 1 |
| 13 | N-acetylcysteine decreases the matrix-degrading capacity of macrophage-derived foam ceils:new target for antioxidant therapy?显示文摘 | Asanuma K Godin D | 1998 | Circulation1998，97，： | 1 |
| 14 | Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | GALIS Z S JOHNSON C GODIN D | 2002 | Circ Res2002，91，： | 1 |
| 15 | Technology Shocks and Monetary Policy:Assessing the Fed's Performance显示文摘 | Gali J Lopez D S Javier V | 2004 | Journal of Monetary Economics2004，50，： | 1 |
| 16 | Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | Galis ZS Johnson C Godin D | 2002 | Circ Res2002，91，： | 1 |
| 17 | Altered body iron distribution and microcytosis in mice deficient in iron regulatory portein 2(IRP2)显示文摘 | Galy B Ferring D Minana B | 2005 | Blood2005，106，7： | 1 |
| 18 | The application of AC impedance to study the performance of lacquered aluminum specimens in ace- tic acid solution 显示文摘 | Scantlebury J D Gali K | 1997 | Progress in organic Coatings1997，31，3： | 1 |
| 19 | Targeted mutagenesis of the murine IRP2 and IRP1 genes reveals context-dependent RNA processing differences in vivo 显示文摘 | Galy B Ferring D Benesova M | 2004 | RNA2004，10，： | 1 |
| 20 | Kinetic and equilibrium mass-dependent isotope fractionation laws in nature and their geochemical and cosmochemieal significance显示文摘 | Young E D Galy A Nagahara H | 2002 | Geoehimiea et Cosmochimica Acta2002，66，6： | 1 |
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