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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Apixaban or enoxaparin for thromboprophylaxis after knee replacement 显示文摘 | Lassen MR Raskob GE Gallus A | 2009 | New E J Med2009，361，： | 1 |
| 3 | Treatment of proximal deep- vein thrombosis with the oral direct factor Xa inhibitor rlvarexaban ( BAY 59-7939 ) : the ODIXa-DVT ( Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Throm- bosis ) study 显示文摘 | Agnelli G Gallus A Goldhabcr SZ | 2007 | Circulation2007，116，2： | 1 |
| 4 | Oral anticoagulant therapy : Antithrombotie Therapy and Prevention of Thrombosis,9th ed:Ameri- can College of Chest Physicians Evidence-Based Clinical Practice Guidelines显示文摘 | Ageno W Gallus )iS Wittkowsky A | 2012 | Chest2012，141，2： | 1 |
| 5 | Apixaban versus enoxaparin for thromboprephylaxis after hip or knee replacement: pooled analysis of major venous thromboembolism and bleeding in 8464 patients from the ADVANCE - 2 and ADVANCE - 3 trials 显示文摘 | RASKOB G E GALLUS A S PINEO G F | 2012 | J Bone Joint Surg Br2012，94，2： | 1 |
| 6 | Warfarin reversal: consensus guidelines, on be- half of the Australasian Society of Thrombosis and Haemostasis显示文摘 | BAKER R I COUGHLIN P B GALLUS A S | 2004 | Med J Aust2004，181，： | 1 |
| 7 | Apixaban or enoxaparin for thromboprophylaxis after knee replacement 显示文摘 | Lassen MR Raskob GE Gallus A | 2009 | N Engl J Med2009，361，： | 1 |
| 8 | Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE - 2 ) : a randomised double - blind trial 显示文摘 | Lassen MR Raskob GE Gallus A | 2010 | Lancet2010，375，： | 1 |
| 9 | Oral anticoagulant therapy : Antithrom- botic Therapy and Prevention of Thronlbosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 显示文摘 | Ageno W Gallus AS Wittkowsky A | 2012 | Chest2012，141，2： | 1 |
| 10 | Apixaban versus enoxaparin for thromboprophylaxis after hip replacement 显示文摘 | Lassen MR Gallus A Raskob GE | 2010 | N Engl J Med2010，363，： | 1 |
| 11 | Participatory ergonomics:Development of an employee assessment questionnaire 显示文摘 | Matthews R A Gallus J A Henning R A | 2011 | Accident Analysis and Prevention2011，43，1： | 1 |
| 12 | Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2):a randomised double-blind trial显示文摘 | Lassen MR Raskob GE Gallus A | 2010 | Lancet2010，375，9717： | 1 |
| 13 | Oral anticoagu- lant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 显示文摘 | Ageno W Gallus AS Wittkowsky A | 2012 | Chest2012，141，2： | 1 |
| 14 | Apixaban versus enoxaparin for thromboprophylaxis after hip replacement显示文摘 | Lassen MR Gallus A Raskob GE | 2010 | N Engl J Med2010，，26： | 1 |
| 15 | Apixaban or enox- aparin for thromboprophylaxis after knee replacement 显示文摘 | Lassen MR Raskob GE Gallus A | 2009 | N Engl J Med2009，361，： | 1 |
| 16 | Oral anticoagulant therapy : Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines 显示文摘 | Ageno W Gallus AS Wittkowsky A | 2012 | Chest2012，141，2： | 1 |
| 17 | Development and Nursing of Constipation显示文摘 | Gallus A S Goghlan D C | 2002 | Curr Opin Pulm Med2002，8，5： | 1 |
| 18 | Apixaban or enoxaparin for thromboprophylaxis after knee replacement显示文摘 | Lassen MR Raskob GE Gallus A | 2009 | N Engl J Med2009，361，6： | 1 |
| 19 | The role of septal surgery in cosmetic rhinoplasty显示文摘 | Parrilla C Artuso A Gallus R | 2013 | Acta Otorhinolaryngol Ital2013，33，3： | 1 |
| 20 | Insulin-like growth factor-1 in colon cancerogenesis:a case-control显示文摘 | Tavani A Gallus S Bosetti C | | 0，，： | 1 |
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