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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Predicting bone mineral density of postmenopausal healthy and cirrhotic Italian women using anthropometric variables显示文摘 | Casini A Mohamed EI Gandin C | 2003 | Dig Liver Dis2003，35，12： | 2 |
| 3 | A three-dimensional cellular automation-finite element model for the prediction of solidification grain structures显示文摘 | Ch. -A. Gandin J. -L. Desbiolles M. Rappaz Ph. Thevoz | | Metallurgical and Materials Transactions A0，，： | 2 |
| 4 | Ebsd characterisation and modeling of columnar dendritic grains growing in the presence of fluid flow 显示文摘 | TAKATANI M GANDIN C A RAPPAZ M | 2000 | Acta Metall2000，48，3： | 1 |
| 5 | Probabilistic modelling of microstructure formation in solidification processes显示文摘 | Rappaz M Gandin Ch-A | 1993 | Acta Metal Mater1993，41，2： | 1 |
| 6 | A coupled finite element-cellular automaton model for the prediction of dendritic grain structure in solidification processes 显示文摘 | Gandin Ch-A Rappaz M | 1994 | Acta Metal Mater1994，42，7： | 1 |
| 7 | A coupled finite element-cellular automaton model for file prediction of dendritic grain structures in solidification processes显示文摘 | Gandin Ch A Rappaz M | 1994 | Acta Metallurgica et Materialia1994，42，7： | 1 |
| 8 | Coupled finite element-cellular automaton model for the prediction of dendritic grain structure in solidification process 显示文摘 | Gandin C A Rappaz M A | 1994 | Acta Metallurgica1994，42，7： | 1 |
| 9 | Probabilistic modeling of microstructure formation in solidification processes 显示文摘 | Rappaz A Gandin C A | 1993 | Acta Metall Master1993，41，2： | 1 |
| 10 | Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis viruis factions显示文摘 | Angelico M Renganathan E Gandin C | 1997 | Hepatol1997，26，2： | 1 |
| 11 | Ebsd Chamcterisation and Modeling of Columnar Dendritic Grains Growing in the Presence of Fluid Flow显示文摘 | Taktani M Gandin Ch-A Rappaz M | 2000 | Acta Metall2000，48，3： | 1 |
| 12 | Probabilistic modelling of microstructure formation in solidification processes显示文摘 | Rappaz M Gandin Ch-A | | 0，，02： | 1 |
| 13 | A three-dimensional cellular automaton-finite element model for the prediction of solidification grain structure 显示文摘 | Gandin C A Desbiolles J L Rappza M | 1999 | Metallurgical and Materials Transactions A-Physical Metallurgy and Materials Science1999，30，12： | 1 |
| 14 | From constrained to unconstrained growth during directional solidification 显示文摘 | Gandin Ch A | 2000 | Acta Metall2000，48，： | 1 |
| 15 | A three-dimensional cellular automaton-finite element model for the prediction of solidification grain structures显示文摘 | Gandin Ch-A Desbiolles J-L Rappaz M | | 0，，： | 1 |
| 16 | A 3D-cellular automaton algorithm for the prediction of dendritic grain growth 显示文摘 | Gandin C A Rappaz M | 1997 | Aeta Materialia1997，45，5： | 1 |
| 17 | Synthesis and in vitro antitumor activity of water soluble sulfonate-and esterfunctionalized silver(I)N-heterocyclic carbene complexes显示文摘 | Gandin V Pellei M Marinelli M | 2013 | J Inorg Biochem2013，129，： | 1 |
| 18 | A 3D cellular automaton algorithm for the prediction of dendritic grain growth显示文摘 | Gandin Ch-A Rappaz M | 1997 | Acta Metal Mater1997，45，5： | 1 |
| 19 | Three-Dimensional simulation of the grain formation in investment casting 显示文摘 | Rappaz M Gandin Ch A Tintillier R | 1994 | Metallurgical Trans1994，25，3： | 1 |
| 20 | Three-dimensional simulation of the grain formation in investment casting显示文摘 | Gandin Ch A Rappz M Tintillier R | 1994 | Metallurgical Transaction1994，25，3： | 1 |
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