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| 1 | c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells显示文摘 | Zuqin Nie Gangqing Hu Gang Wei Kairong Cui Arito Yamane Wolfgang Resch Ruoning Wang Douglas R. Green Lino Tessarollo Rafael Casellas Keji Zhao David Levens | 2012 | Cell2012，，1： | 1 |
| 2 | Tectonics and denudation adjacent to the Xuanshuihe Fault,eastern Tibetan Plateau:Constraints from fission track thermochronology显示文摘 | XUE Gangqing KAMP P J | 2000 | Journal of Geophysical Research2000，105，19： | 1 |
| 3 | Empowering beginners in bioinformatics with ChatGPT显示文摘The impressive conversational and programming abilities of ChatGPT make it an attractive tool for facilitating the education of bioinformatics data analysis for beginners.In this study,we proposed an iterative model to fine-tune instructions for guiding a chatbot in generating code for bioinformatics data analysis tasks.We demonstrated the feasibility of the model by applying it to various bioinformatics topics.Additionally,we discussed practical considerations and limitations regarding the use of the model in chatbot-aided bioinformatics education. | Evelyn Shue Li Liu Bingxin Li Zifeng Feng Xin Li Gangqing Hu | 2023 | Quantitative Biology2023，11，2： | 0 |
| 4 | Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction显示文摘Articular cartilage has a limited capacity to self-heal once damaged.Tissue-specific stem cells are a solution for cartilage regeneration;however,ex vivo expansion resulting in cell senescence remains a challenge as a large quantity of high-quality tissue-specific stem cells are needed for cartilage regeneration.Our previous report demonstrated that decellularized extracellular matrix(dECM)deposited by human synovium-derived stem cells(SDSCs),adipose-derived stem cells(ADSCs),urine-derived stem cells(UDSCs),or dermal fibroblasts(DFs)provided an ex vivo solution to rejuvenate human SDSCs in proliferation and chondrogenic potential,particularly for dECM deposited by UDSCs.To make the cell-derived dECM(C-dECM)approach applicable clinically,in this study,we evaluated ex vivo rejuvenation of rabbit infrapatellar fat pad-derived stem cells(IPFSCs),an easily accessible alternative for SDSCs,by the abovementioned C-dECMs,in vivo application for functional cartilage repair in a rabbit osteochondral defect model,and potential cellular and molecular mechanisms underlying this rejuvenation.We found that C-dECM rejuvenation promoted rabbit IPFSCs’cartilage engineering and functional regeneration in both ex vivo and in vivo models,particularly for the dECM deposited by UDSCs,which was further confirmed by proteomics data.RNA-Seq analysis indicated that both mesenchymal-epithelial transition(MET)and inflammation-mediated macrophage activation and polarization are potentially involved in the C-dECM-mediated promotion of IPFSCs’chondrogenic capacity,which needs further investigation. | Ming Pei Yixuan Amy Pei Sheng Zhou Elmira Mikaeiliagah Christopher Erickson Benjamin Giertych Halima Akhter Lei Wang Amanda Stewart Joshua Parenti Bin Wang Sijin Wen Sotcheadt Sim Eric Quenneville Kirk C.Hansen Steven Frisch Gangqing Hu | 2023 | Bioactive Materials2023，，5： | 0 |
| 5 | The artificial intelligence pharma era after“Chat Generative Pre-trained Transformer”显示文摘The era of advanced artificial intelligence has arrived with the development of chatbots like ChatGPT(Chat Generative Pre-trained Transformer).As described by Ouyang et al.(2022),ChatGPT demonstrates an impressive ability to generate human-like responses and solve practical problems,surpassing original expectations for its capabilities.The rapid release and adoption of ChatGPT signals a new phase in AI development,powered by large language models that can be fine-tuned through human feedback.However,risks remain regarding how such powerful models may be misused.Further research is needed to ensure safe and ethical deployment of these transformative technologies. | Zhengwei Xie Gangqing Hu | 2023 | Medical Review2023，3，3： | 0 |
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