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| 1 | 第二代液态电渣冶金技术的发展显示文摘描述了基于导电结晶器的第二代液态电渣冶金技术的原理、特点和应用情况,主要包括液态电渣浇注实心锭、空心锭和复合轧辊。同时,介绍了采用液态电渣浇注技术制备双金属耐腐蚀钢筋和铜钢复合电极的试验结果。最后,对今后的发展提出了展望,指出液态电渣浇注技术与连铸工艺的结合将是今后的发展趋势,并提出了液态电渣多次多层复合法制备特大型钢锭的可行性。 | 姜周华 Lev Medovar Ganna Stovpchenko 董艳伍 臧喜民 刘福斌 | 2013 | 钢铁研究学报2013，25，3： | 7 |
| 2 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 3 | SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity显示文摘There is a link between high lipopolysaccharide(LPS)levels in the blood and the metabolic syndrome,and metabolic syndrome predisposes patients to severe COVID-19.Here,we define an interaction between SARS-CoV-2 spike(S)protein and LPS,leading to aggravated inflammation in vitro and in vivo.Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS.Microscale thermophoresis yielded a of〜47 nM for the interaction.Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results,identifying a main LPS-binding site in SARS-CoV-2 S protein.S protein,when combined with low levels of LPS,boosted nuclear factor-kappa B(NF-k B)activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells,respectively.The in vitro inflammatory response was further validated by employing NF-kB reporter mice and in vivo bioimaging.Dynamic light scattering,transmission electron microscopy,and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS,providing a molecular explanation for the observed boosting effect.Taken together,our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins. | Ganna Petruk Manoj Puthia Jitka Petrlova Firdaus Samsudin Ann-Charlotte Stromdahl Samuel Cerps Lena Uller Sven Kjellstrom Peter J.Bond Artur Schmidtchen | 2020 | Journal of Molecular Cell Biology2020，12，12： | 3 |
| 4 | A case study of the role of climate, humans, and ecological setting in Holocene fire history of northwestern Europe显示文摘We present the major results from studies of fire history over the last 11000 years(Holocene) in southern Sweden, on the basis of palaeoecological analyses of peat sequences from three small peat bogs. The main objective is to emphasize the value of multiple, continuous sedimentary records of macroscopic charcoal(macro-C) for the reconstruction of local to regional past changes in fire regimes, the importance of multi-proxy studies, and the advantage of model-based estimates of plant cover from pollen data to assess the role of tree composition and human impact in fire history. The chronologies at the three study sites are based on a large number of 14 C dates from terrestrial plant remains and age-depth models are achieved using Bayesian statistics. Fire history is inferred from continuous records of macro-C and microscopic charcoal counts on pollen slides. The Landscape Reconstruction Algorithm(LRA) for pollen-based quantitative reconstruction of local vegetation cover is applied on the three pollen records for plant cover reconstruction over the entire Holocene. The results are as follows:(1) the long-term trends in fire regimes are similar between sites, i.e., frequent fires during the early Holocene until ca. 9 ka BP, low fire frequency during the mid-Holocene, and higher fire frequency from ca. 2.5 ka BP;(2) this broad trend agrees with the overall fire history of northwestern and western Europe north of the Mediterranean area, and is due to climate forcing in the early and mid-Holocene, and to anthropogenic land-use in the late Holocene;(3) the LRA estimates of plant cover at the three sites demonstrate that the relative abundance of pine played a primordial role in the early and mid-Holocene fire history; and(4) the between-site differences in the charcoal records and inferred fire history are due to local factors(i.e., relative abundance of pine, geomorphological setting, and anthropogenic land-use) and taphonomy of charcoal deposition in the small peat bogs. It is shown that continuous macro-C records are most useful to disentangle local from regional-subcontinental fire history, and climate-induced from human-induced fire regimes, and that pollen-based LRA estimates of local plant cover are more adequate than pollen percentages for the assessment of the role of plant composition on fire history. | CUI QiaoYu Marie-José GAILLARD Fredrik OLSSON Annica GREISMAN Geoffrey LEMDAHL Ganna ZERNOVA | 2015 | Science China Earth Sciences2015，58，2： | 2 |
| 5 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 6 | Peripheral blood mononuclear cells proliferation and Th1/Th2 cytokine production in response to streptococcal M protein in psoriatic patients 显示文摘 | P rez - Lorenzo R N ez - Oreza LA Ganna - Quen PM | 2006 | Int J Dermatol2006，45，5： | 1 |
| 7 | Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series 显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | neurosurgery2008，62，5： | 1 |
| 8 | Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions:indications and limitations显示文摘 | Dehdashti AR Ganna A Witterick I | | 0，，： | 1 |
| 9 | Pure endoscopic endonassal approach for pituitary adenomas:early surgical results in 200 patients and comparison with previous mierosurgical series显示文摘 | Dehdashi AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，： | 1 |
| 10 | Pure endo- scopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with pre- vious microsurgical series 显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，5： | 1 |
| 11 | Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series 显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，5： | 1 |
| 12 | Large- scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease 显示文摘 | GANNA A SALIHOVIC S SUNDSTROM J | 2014 | PLoS Genet2014，10，10： | 1 |
| 13 | Applied Real-time Acoustic Chemometrics for Measurements of Canadian Standard Freeness显示文摘 | Bjork A Danielsson L-G Ganna A | 2005 | Paperi ja Puu2005，87，7： | 1 |
| 14 | Pure endoscopic endonasal approach for pituitary adenomas:early surgical results in 200 patients and comparison with previous microsurgical series显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，： | 1 |
| 15 | Pure endoscopic endonasal approach for pituitary adenomas : early surgical results in 200 patients and comparison with previous microsurgical series 显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，5： | 1 |
| 16 | New insights into the mechanism of amine/nitroxide cycling during the hindered amine light stabilizer inhibited oxidative degradation of polymers显示文摘 | Ganna Gryn'ova Ingold K U Michelle L Coote | 2012 | Journal of American Chemical Society2012，134，12： | 1 |
| 17 | The impact of terrorism on financial markets: An empirical study显示文摘 | Marc Chesney Ganna Reshetar Mustafa Karaman | 2010 | Journal of Banking and Finance2010，，： | 1 |
| 18 | Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series 显示文摘 | Dehdashti AR Ganna A Karabatsou K | 2008 | Neurosurgery2008，62，5： | 1 |
| 19 | Akt2 deficiency as a therapeutic strategy protects against acute lung injury 显示文摘 | Ganna AE Cha S | 2014 | Immunotherapy2014，6，4： | 1 |
| 20 | New insights into the mechanism of amine/nitroxide cycling during the hindered amine light stabilizer inhibited oxidative degradation of polymers显示文摘 | Ganna Gryn ova Ingold K U Michelle L Coote | 2012 | J Am Chem Soc2012，134，12： | 1 |
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