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2篇 您的检索式:作者名="Gaobo Hong"
    题名 作者 年代 出处 被引量
1Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy显示文摘A variety of nano-engineered photosensitizers have been developed for photodynamic therapy(PDT)of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leakage and premature release, and have disadvantages such as low drug load and inaccurate release.The self-assembly strategy based on amphiphilic peptides has been considered to be more attractive nano-engineering method. Here we developed novel acid-activatable self-assembled nanophotosensitizers based on an amphiphilic peptide derivative. The peptide derivative was synthesized from a fluorescein molecule with thermally activated delayed fluorescence(TADF). The self-assembled nanophotosensitizers can specifically enter the tumor cells and disassemble inside lysosomes companied with “turn-on” fluorescence and photodynamic therapy effect. Such smart nanophotosensitizers will open new opportunities for cancer theranostics.Shuang Chen Yongzhuo Liu Ri Liang Gaobo Hong Jing An Xiaojun Peng Wen-Heng Zheng Fengling Song 2021Chinese Chemical Letters2021,32,12:0
2新一代固体捆绑火箭空间弹性模态建模与控制显示文摘In this paper,based upon the characteristics of elastic modal combination of large solid bundled launch vehicles,the finite element theory is used to describe the complex elastic vibration of a solid bundled launch vehicle,and a new three-channel unified elastic vibration equation was established.The elastic vibration equation can reflect the coupling between channels and between boosters and core stage.Some issues need consideration in the theoretical derivation,an engineering application was proposed,and the elastic vibration model was verified.The results of the theoretical derivation and simulation show that the elastic vibration equation of a solid bundled launch vehicle established in the paper is correct and can meet the needs for the engineering application.Hong Gang XIN Gaobo LIU Yuxi XUE Yu SONG Pan YANG Xinru 2022Aerospace China2022,23,2:0
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