| 1 | Treatment and survival status of patients with EGFR mutation-positive stage Ⅳ lung adenocarcinoma: five-year follow-up results in the Ordos Area of Inner Mongolia, China显示文摘Objective We aimed to determine the epidermal growth factor receptor(EGFR) mutation status and treatment survival of patients with stage Ⅳ lung adenocarcinoma living in the Ordos area of Inner Mongolia, China.Methods EGFR testing and first-line tyrosine kinase inhibitor(TKI) treatment rates of patients with stage Ⅳ lung adenocarcinoma were analyzed from June 2012 to June 2016. Kaplan-Meier survival curves were constructed to compare patients who received different treatment strategies and those harboring different EGFR mutation statuses.Results EGFR testing and mutation rates were 65.60% and 52.90%, respectively, and improved continuously from June 2012 to June 2016. Among patients with EGFR mutations, 38.9% had EGFR 19 del, 48.2% had L858 R, 4.2% had co-existing mutations in exons 19 and 21, and 8.4% had uncommon mutations. The median overall survival(OS) was 29.5, 26.5, and 16.0 months for patients receiving both TKI and chemotherapy, TKI alone, and chemotherapy alone, respectively(P = 0.047). The OS was 26.5 and 30.0 months for patients harboring EGFR 19 del and L858 R mutations, respectively(P = 0.096).Conclusion The high OS rates of stage Ⅳ lung adenocarcinoma patients living in the Ordos area may be attributed to continuous improvements in EGFR testing and first-line TKI treatment rates. In the era of TKIs, chemotherapy for increasing OS times should be emphasized. | Gaowa Jin Wenjuan Wang Shuqin Deng Caihong Jiang Xiaojun Bai Jun Zhao Feng Chen Jixiang Hou Lanzhen Zhao Hui Li Ziyu Lu Lenggaowa Da Yungaowa Wu Xiaoyun Ma Yahan Wu Jiali Gao Quanfu Li | 2018 | Oncology and Translational Medicine2018，4，4： | 0 |
| 2 | NP方案联合不同间隔时间放疗对乳腺癌MCF-7细胞作用研究(英文)显示文摘Objective: To evaluate the effect of the treatment by vinovelbine (NVB) and cisplatin (DDP) with radiation at dif- ferent timing intervals on the radiosensitivity of human breast cancer cell MCF-7. Methods: Six groups (at the interval of 0 h, 4 h, 12 h, 36 h, 48 h, 72 h between chemotherapy and radiotherapy) were studied by cologenic formation assay. In addition, the effect of different timing intervals between chemotherapy and radiotherapy on cell cycle distribution and apoptosis induc- tion in MCF-7 cells was also studied. Quantitation of the apopotic cells was performed by Flow cytometry measurements. For the qualitative detection, fluorescence microscopy analysis was used. Results: The six groups had different SF data, it was the lowest one at the intervals 12 h group, the middest one at 0 h groups, and the highest one at 48 h, 72 h groups when the radiation dose was 8 Gy. In some degree, the different SF data of the six groups could been explained by the different percent- age accumulation of G2/M phase at different timing caused by the NP chemotherapy. Apoptosis index after chemotherapy increased with time extending, but the changes of apoptosis index seem not correlate with the SF differences. Conclusion: The different timing intervals between NP chemotherapy and radiotherapy affect the radiosensitivity of MCF-7 cells, but those changes according to the interactive of cycle distribution and apoptosis. | Quanfu Li Gaowa Jin Wenhui Li | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 0 |
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