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| 1 | Emerging role of junctophilin-2 as a regulator of calcium handling in the heart显示文摘Junctophilin-2 (JPH2 ) 是在心脏的 myocytes 在 junctional 膜建筑群(JMC ) 的组织起一个关键作用的膜绑定蛋白质。JPH2 被相信在 JMC 以内在固定距离保留血浆膜和 sarcoplasmic 蜂窝胃,它在刺激收缩过程期间为合适的导致 Ca2+ 的 Ca2+ 版本是必要的。最近的研究表明了在 JPH2 基因的变化与 hypertrophic 心肌症被联系,强调为正常心脏的生理学的这蛋白质的重要性。在这份报纸,我们在心关于 junctophilin-2 的结构和功能考察当前的知识。 | Alejandro GARBINO | 2010 | Acta Pharmacologica Sinica2010，31，9： | 7 |
| 2 | Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study显示文摘BACKGROUND Esophageal cancer(ESCA)is the sixth most common malignancy in the world,and its incidence is rapidly increasing.Recently,several microRNAs(miRNAs)and messenger RNA(mRNA)targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis.In addition,computed tomography(CT)radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment.Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.AIM To explore the combination of CT radiomic features and molecular targets associated with clinical outcomes for characterization of ESCA patients.METHODS Of 15 patients with diagnosed ESCA were included in this study and their CT imaging and transcriptomic data were extracted from The Cancer Imaging Archive and gene expression data from The Cancer Genome Atlas,respectively.Cancer stage,history of significant alcohol consumption and body mass index(BMI)were considered as clinical outcomes.Radiomic analysis was performed on CT images acquired after injection of contrast medium.In total,1302 radiomics features were extracted from three-dimensional regions of interest by using PyRadiomics.Feature selection was performed using a correlation filter based on Spearman’s correlation(ρ)and Wilcoxon-rank sum test respect to clinical outcomes.Radiogenomic analysis involvedρanalysis between radiomic features associated with clinical outcomes and transcriptomic signatures consisting of eight N6-methyladenosine RNA methylation regulators and five up-regulated miRNA.The significance level was set at P<0.05.RESULTS Of 25,five and 29 radiomic features survived after feature selection,considering stage,alcohol history and BMI as clinical outcomes,respectively.Radiogenomic analysis with stage as clinical outcome revealed that six of the eight mRNA regulators and two of the five up-regulated miRNA were significantly correlated with ten and three of the 25 selected radiomic features,respectively(-0.61<ρ<-0.60 and 0.53<ρ<0.69,P<0.05).Assuming alcohol history as clinical outcome,no correlation was found between the five selected radiomic features and mRNA regulators,while a significant correlation was found between one radiomic feature and three up-regulated miRNAs(ρ=-0.56,ρ=-0.64 andρ=0.61,P<0.05).Radiogenomic analysis with BMI as clinical outcome revealed that four mRNA regulators and one up-regulated miRNA were significantly correlated with 10 and two radiomic features,respectively(-0.67<ρ<-0.54 and 0.53<ρ<0.71,P<0.05).CONCLUSION Our study revealed interesting relationships between the expression of eight N6-methyladenosine RNA regulators,as well as five up-regulated miRNAs,and CT radiomic features associated with clinical outcomes of ESCA patients. | Valentina Brancato Nunzia Garbino Lorenzo Mannelli Marco Aiello Marco Salvatore Monica Franzese Carlo Cavaliere | 2021 | World Journal of Gastroenterology2021，27，36： | 3 |
| 3 | Inappropriate initi-al antimicrobial therapy and its effect on survival in a clin-ical trial of immunomodulating therapy for severe sepsis显示文摘 | Harbarth S Garbino J Pugin J | 2003 | AmJMed2003，115，7： | 1 |
| 4 | Successful treatment of pulmonary invasive aspergillosis with voriconazole in patients who failed conventional therapy 显示文摘 | Garbino J Rohner P Kolarova L etal | 2003 | Infection2003，31，4： | 1 |
| 5 | Epidemiology of Candida species infections in critically ill non-immunosuppressed patients 显示文摘 | Eggimann P Garbino J Pittet D | 2003 | Lancet Infect Dis2003，3，： | 1 |
| 6 | Epidemiology of Candi-da species infections in critically ill non-immunosup-pressed patients显示文摘 | Eggimann P Garbino J PittetD | 2003 | Lancet Infect Dis2003，3，11： | 1 |
| 7 | Respiratory viruses in bron- choalveolar lavage: a hospital - based cohort study in adults 显示文摘 | Garbino J Soccal PM Aubert JD | 2009 | Thorax2009，64，5： | 1 |
| 8 | Caspofung in the treatment of oropharyngeal candidi- asis显示文摘 | Garbino | 2003 | Int J Clin Praet2003，57，2： | 1 |
| 9 | Lower respirato- ry viral illnesses improved diagnosis by molecular methods and clinical impact显示文摘 | Garbino J Gerbase M W Wunderli W | 2004 | Am J Respir Crit Care Med2004，170，11： | 1 |
| 10 | Ecstasy ingestion and fulminant hepatic failure:liver transplantation to be considered as a last therapeutic option 显示文摘 | Garbino J Henry JA Mentha G | 2001 | Vet Hum Toxicol2001，43，2： | 1 |
| 11 | 显示文摘 | Garbino J Rohner P Kolarova L | 2003 | Infection2003，31，： | 1 |
| 12 | Antibiotic consumption, bacterial resistance and their correlation in a Swiss university hospital and its adult intensive care units 显示文摘 | Loeffler J M Garbino J Lew D | 2003 | Scand J Infect Dis2003，35，： | 1 |
| 13 | Caspofungin in the treatment of oropharyngeal candidiasis显示文摘 | Garbino J Lew D Hirschel B | 2003 | Int J Clin Pract2003，57，2： | 1 |
| 14 | Epidemiology of Candida species infections in critically ill non-immunosuppressed patients 显示文摘 | Eggimann P Garbino J Pittet D | 2003 | Lancet Infect Dis2003，3，11： | 1 |
| 15 | Lenercept (p55 tu- mor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo- controlled, multicenter phase trial with 1342 patients显示文摘 | Abraham E Laterre PF Garbino ] et 01 | 2001 | Crit Care Med2001，29，3： | 1 |
| 16 | Caspofungin in the treatment of oropharyngeal candidiasis显示文摘 | Garbino J Lew D HirschelB | 2003 | Int J Clin Pract2003，57，2： | 1 |
| 17 | Epidemiology of Candida spe- cies infections in critically ill non-immunosuppressed pa- tients 显示文摘 | Eggimann P Garbino J Pittet D | 2003 | Lancet Infect Dis2003，3，： | 1 |
| 18 | Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis显示文摘 | Butty VL Roux-Lombard P Garbino J | 2003 | Eur Cytokine Netw2003，14，1： | 1 |
| 19 | Nocardiosis:updated clinical review and experience at a tertiary center显示文摘 | Ambrosioni J Lew DJ Garbino J | 2010 | Infection2010，38，2： | 1 |
| 20 | Disseminated histoplasmosis in an HIV-infected patient discovered by routine blood smear staining显示文摘 | Matulionyte R Garbino J Uckay I | 2005 | Eur J Clin Mierobiol Infect Dis2005，24，5： | 1 |
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