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| 1 | Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer显示文摘瞄准:肿瘤蛋白质的 Overexpression 导致 p53 的原子蛋白质(TP53INP1 ) 1 导致 G1 房间周期拘捕并且增加调停 p53 的 apoptosis。澄清 TP53INP1 的临床的重要性,我们在胃的癌症分析了 TP53INP1 和 p53 表示。方法:TP53INP1 和 p53 表示在胃的癌症的 142 种情况中用免疫组织化学被检验。胃的癌症房间的 apoptosis 用 TUNEL 方法被分析。在 TP53INP1 和 clinicopathological 因素的表示之间的关系统计上被分析。结果:TP53INP1 在 98% 被表示(139/142 盒子) 非癌的胃的纸巾并且在 64% 是下面表示的(91/142 盒子) 从一样的病人的胃的癌症损害。TP53INP1 表示显著地被减少(43.9%) 与井相比或中等在糟糕区分的腺癌区分了腺癌(81.6%) 。入侵粘膜下层的癌症或更深出现了断然降低(59.1%) 与粘膜癌症(85.2%) 相比。TP53INP1 表示的减少或损失显著地与淋巴的侵略被相关(54.3% 对 82.0% 没有淋巴的侵略) 并且节点积极的病人(31.3% 对 68.3% 在节点否定的病人) 。P53 在 68 被表示(47.9%) 胃的癌症的病人,而它在正常胃的纸巾是不在的。一个重要协会也在肿瘤房间在 TP53INP1 地位和 apoptosis 的水平之间被观察:在 TP53INP1 积极的纸巾的 apoptotic 索引在 TP53INP1 否定的部分比那显著地高。最后,当幸存数据被分析时, TP53INP1 表示的损失在预言差的预后(P=0.0006 ) 有重要效果。结论:有胃的癌症的前进的 TP53INP1 积极的率减少。TP53INP1 蛋白质否定性显著地与胃的癌症的好攻击的病理学的显型被联系。TP53INP1 与胃的癌症房间的 apoptosis 有关。TP53INP1 蛋白质的减少的表示可以反映胃的癌症的恶意的等级并且被认为是一个不利预示的因素。 | Pei-Hong Jiang Yoshiharu Motoo Stéphane Garcia Juan Lucio Iovanna Marie-Josèphe Pébusque Norio Sawabu | 2006 | World Journal of Gastroenterology2006，12，5： | 3 |
| 2 | Correlation between the cytotoxicity of melphalan and DNA crosslinks as detected by the ethidium bromide fluorescence assay in the FI varient of BI6 melanoma cells显示文摘 | Garcia ST McQuillan A Panasci L | 1988 | Biochem Pharmacol1988，37，16： | 1 |
| 3 | An HIV-1 clade C DNA prime,NYVAC boost vaccine regimen induces reliable,polyfunctional,and long-lasting T cell responses显示文摘 | Harari A Bart PA St(o)hr W Tapia G Garcia M Medjitna-Rais E Burnet S Cellerai C Erlwein O Barber T Moog C Liljestrom P Wagner R Wolf H Kraehenbuhl JP Esteban M Heeney J Frachette MJ Tartaglia J McCormack S Babiker A Weber J Pantaleo G | 2008 | J Exp Med2008，205，1： | 1 |
| 4 | Comparative genomics modeling of the NRSF/REST repressor network : from sin- gle conserved sites to genome-wide repertoirev 显示文摘 | Mortazavi A Leeper Thompson EC Garcia ST | 2006 | Genome Res2006，16，： | 1 |
| 5 | Systemic arterial expression of matrix metalloproteinases 2 and 9 in Kawasaki disease 显示文摘 | Gavin PJ Crawford SE Shulman ST Garcia FL Rowley AH | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 6 | Effects of voucher-based intervention on abstinence and retention in an outpatient treatment for cocaine addiction:a randomized controlled trial显示文摘 | Garcia RO Secades VR Higgins ST | 2009 | Exp Clin Psychopharmacol2009，17，3： | 1 |
| 7 | Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease 显示文摘 | Gavin PJ Crawford SE Shulman ST Garcia FL Rowlev AH | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 8 | Financing a voucher program for cocaine abusers through community donations in Spain显示文摘 | Garcia RO Secades VR Higgins ST | 2008 | J Appl Behav Anal2008，41，： | 1 |
| 9 | Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance显示文摘To reduce the burden of denture stomatitis and oral candidiasis,an aqueous solution containing polyhexamethylene guanidine hydrochloride(PHMGH)was investigated as an antifungal disinfectant against the leading cause of these oral conditions,Candida albicans.The solutions formulated with concentrations ranging from 0.125 to 0.50 wt%enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens.After 10 min-contact,the solution at lower concentration has reached total fungal elimination.The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration.The PHMGH aqueous solutions at 0.125 wt%could be applied to promote interim denture liner disinfection without promoting the loss of materials’mechanical property. | Isadora Martini Garcia Stéfani Becker Rodrigues Maria Eduarda Rodrigues Gama Vicente Castelo Branco Leitune Mary Anne Melo Fabrício Mezzomo Collares | 2020 | Bioactive Materials2020，5，2： | 0 |
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