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| 1 | 因子Ⅶ-金黄色葡萄球菌肠毒素A融合蛋白的抗肿瘤效果显示文摘目的研究鼠因子Ⅶ(mfⅦ)与金黄色葡萄球菌肠毒素A(SEA)融合蛋白的抗肿瘤生长和转移活性。方法构建表达Ⅶ因子SEA融合蛋白的腺病毒载体,用293包装细胞系制备病毒Ad/mfⅦSEA。局部荧光检测证明其表达能力和安全性后,直接应用病毒感染的293细胞以皮下注射的方式进行试验。采用小鼠205H12肺转移模型和小鼠RM1皮下肿瘤模型检测mfⅦSEA对小鼠皮下肿瘤生长和肺转移形成的抑制情况。结果腺病毒感染的293细胞诱导的二次感染只在注射局部产生,而对心、肝、肾等重要脏器无任何影响。小鼠体内实验结果显示,mfⅦSEA治疗组肺转移数(23±8)与空载体对照组(193±38)和PBS对照组(211±42)相比,差异有统计学意义(P<0.01)。在抗小鼠前列腺肿瘤的动物实验中,mfⅦSEA对皮下肿瘤的抑制非常明显,第23天时,治疗组皮下肿瘤的体积平均为(342.6±107.1)mm3,明显小于空载体对照组(2244.3±350)mm3和SEA对照组(1208.3±210)mm3。结论mfⅦSEA融合蛋白能明显抑制小鼠皮下肿瘤的生长和肺转移的形成。 | 李进 孙颖 Masako Chen 李锋 Alan Garen | 2005 | 中华肿瘤杂志2005，27，8： | 3 |
| 2 | Pensions, non-discrimination policies, and the employment of older workers显示文摘 | John Garen Mark Berger Frank Scott | 1996 | Quarterly Review of Economics and Finance1996，，4： | 2 |
| 3 | Cloning,expression,purification,crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis显示文摘 | Biswal B K Garen G Cherney M M | | 0，，02： | 1 |
| 4 | Malignant rhabdoid tumor of the central nervous system显示文摘 | Biggs P J Garen P D Powers J M | 1987 | Hum Pathol1987，18，4： | 1 |
| 5 | Anti-melanoma antibodies from melanoma patients immunized with genetically modified autolagous tumor cells: selec- tion of specific antibodies from single-chain Fv fusion phage li- braries 显示文摘 | Cai X Garen A | 1995 | Proe Natl Aead Sei USA1995，92，： | 1 |
| 6 | Targeting tumor vaseulature endothelial cells and tumor ceils for immunotherapy of human melanoma in a mouse xenograft model 显示文摘 | Hu Z Sun Y Garen A | 1999 | Proe Natl Acad Sci USA1999，96，14： | 1 |
| 7 | Targeting tissue factor on tumor vascular endothelial ceils and tumor cells for immunotherapy in mouse models of prostatic cancer显示文摘 | Hu Z Garen A | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 8 | Intratumoral injection of adenoviral vectors encoding tumor targeted immunoconjugates for cancer immunotherapy显示文摘 | Hu Z Garen A | 2000 | Proc Natl Acad Sci USA2000，97，16： | 1 |
| 9 | Oral distress in primary Sjogren's syndrome:implications for health-related quality of life显示文摘 | Enger TB Palm O Garen T | 2011 | Eur J Oral Sci2011，119，6： | 1 |
| 10 | Roles of PSF protein and VL30 RNA in reversible gene regulation 显示文摘 | Song X Sun Y Garen A | 2005 | Proc Natl Acad Sci USA2005，34，12： | 1 |
| 11 | From a retrovirus infection of mice to a long noncoding RNA that induces proto-oncogene transcription and oncogenesis via an epigenetic transcription switch显示文摘Here I review the properties of the mouse retroelement VL30-1,which apparently derived from retrotranspostions of a founder VL30 retrovirus that infected the mouse germline after the mouse–human speciation.The VL30-1 gene is transcribed as a long noncoding RNA(lncRNA)with an essential host function in an epigenetic transcription switch(ETS)that regulates transcription of multiple genes,including proto-oncogenes that control cell proliferation and oncogenesis.The ETS involves the tumor suppressor protein PSF that has a DNA-binding domain(DBD)and two RNA-binding domains(RBDs).The DBD binds to promoters that have a DBD-binding sequence and switches off transcription,and the RBDs bind lncRNAs that have a RBD-binding sequence,releasing PSF and switching on transcription.VL30-1 lncRNA has two RBD-binding sequences,apparently acquired by mutations during retrotranspositions of the founder retrovirus,which drive proto-oncogene transcription and oncogenesis via the ETS.VL30-1 lncRNA is a seminal example of the key role of endogenous retroviruses(ERVs)and their retroelements in the evolution of transcription regulatory systems. | Alan Garen | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 12 | Clinical pulmonaryinvolvement in primary Sjogren syndrome: prevalence, qualityof life and mortality: a retrospective study based on registry data显示文摘 | Palm 0 Garen T Berge Enger T | 2013 | Rheumatology (Oxford)2013，52，1： | 1 |
| 13 | Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells显示文摘 | Cai X Garen A | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 14 | The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clini- cally related connective tissue diseases 显示文摘 | Flam ST Gunnarsson R Garen T | 2015 | Rheumatology (Ox- ford)2015，54，3： | 1 |
| 15 | Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries显示文摘 | Garen A | 1995 | Proc Natl Acad Sci USA1995，92，14： | 1 |
| 16 | Anti-melanoma antihedies from melanoma patients immunized with genetieaUy modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries 显示文摘 | CAI X GAREN A | 1995 | Proe Nail Acad Sci USA1995，92，： | 1 |
| 17 | Probability of Purchase,Amount of Purchase,and the Demographic Incidence of the Lottery Tax显示文摘 | Scott F Garen J | 1994 | Journal of Public Economics1994，54，1： | 1 |
| 18 | Capitalization of R&D costs and earnings management:Evidence from Italian listed companies显示文摘 | Garen Markarian Lorenzo Pozza Annalisa Prencipe | | 0，，43： | 1 |
| 19 | Simulating snowmelt processes during rain-on-snow over a semiarid mountain basin 显示文摘 | Marks D Link T Winstral A Garen D | 2001 | Annals of Glaciology2001，32，： | 1 |
| 20 | Anti -melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor ceils: selection of specific antibodies from single-chain Fv fusion phage libraries显示文摘 | Cai X Garen A | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
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