|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Why interleukin-10 supplementation does not work in Crohn's disease patients显示文摘Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in 'Westernised' countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit. | Gareth J Marlow Dominique van Gent Lynnette R Ferguson | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 2 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 4 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 5 | Pancreaticopleuralfistula:etiology,treatmentandlong-termfollow-up显示文摘BACKGROUND:Pancreaticopleural fistula(PPF) are uncommon.Complex multidisciplinary treatment is required due to nutritional compromise and sepsis.This is the first description of long-term follow-up of patients with PPF.METHODS:Eleven patients with PPF treated at a specialist unit were identified.Causation,investigation,treatment and outcomes were recorded.RESULTS:Pancreatitis was the etiology of the PPF in 9 patients,and in the remaining 2 the PPF developed following distal pancreatectomy.Cross-sectional imaging demonstrated the site of duct disruption in 10 cases,with endoscopic retrograde cholangiopancreatography identifying the final case.Suppression of pancreatic exocrine secretion and percutaneous drainage formed the mainstay of treatment.Five cases resolved following pancreatic duct stent insertion and three patients required surgical treatment for established empyema.There were no complications.In all cases that resolved there has been no recurrence of PPF over a median follow-up of 50 months(range 15-62).CONCLUSIONS:PPF is an uncommon event complicating pancreatitis or pancreatectomy;pancreatic duct disruption is the common link.A step-up approach consisting of minimally invasive techniques treats the majority with surgery needed for refractory sepsis. | Keith J Roberts Maria Sheridan Gareth Morris-Stiff Andrew M Smith | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
| 6 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 7 | Application of ultrasound to materials chemistry显示文摘 | Gareth J P | 1999 | Annu Rev Mater Sci1999，36，2： | 1 |
| 8 | Sources of sedimentary lipids deduced from stable carbon isotope analyses of individual compounds 显示文摘 | Gareth Rieley Robert J Collier David M Jones Geoffrey Eglinton Paul A Eakin Anthony E Fallick | 1991 | Nature1991，352，： | 1 |
| 9 | Applications of ultrasound to materials chemistry 显示文摘 | Kenneth S S Gareth J P | 1999 | Annu Rev Mater Sci1999，29，： | 1 |
| 10 | Ultrasonically assisted synthesis and degradation of poly ( dimethyl siloxane) 显示文摘 | Gareth J P Matthew P H Emma N K W | 1996 | Polymer1996，37，12： | 1 |
| 11 | The extent of codor usagc bias in human RNA viruses and its evolutionary origia 显示文摘 | Gareth M J Edward C H | 2003 | Virus Res2003，92，： | 1 |
| 12 | Inflammatory Gene Expression in Response Io Sub-lethal Ricin Exposurein Balb/c Mice 显示文摘 | onathan D Lucy J W Gareth 1) G | 2009 | Toxicology2009，264，： | 1 |
| 13 | Barriers to physical activity among predominantly low-income african-american patients with type 2 diabetes显示文摘 | Gareth R Johnson J Whitehead D | 2005 | Diabetes Care2005，28，： | 1 |
| 14 | The extent of codon usage bias in human RNA viruses and its evolutionary origin显示文摘 | Gareth M J Edward C H | 2003 | Virus Res2003，92，： | 1 |
| 15 | SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase(ALK) receptors ALK4,ALK5, and ALKT显示文摘 | GARETH J I FRANCISCO J N JAMES F C | 2002 | Mol Pharmaco12002，62，1： | 1 |
| 16 | Lymphoepithelial cysts of the pancreas:a management dilemma显示文摘Pancreatic lymphoepithelial cysts(LECs) are rare,benign lesions that are typically unexpected post-operative pathological findings. We aimed to review clinical, radiological and pathological features of LECs that may allow their preoperative diagnosis. Histopathology databases of two large pancreatic units were searched to identify LECs and notes reviewed to determine patient demographic details, mode of presentation, investigations, treatment and outcome. Five male and one female patients were identified. Their median age was 60 years. Lesions were identified on computed tomography performed for abdominal pain in two patients, and were incidentally observed in four patients. Five LECs were located in the tail and one in the body of the pancreas, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a largely acellular aspirate was yielded. The pre-operative diagnosis was mucinous cystic neoplasm in all patients. This series of patients were treated distal pancreatectomy and splenectomy. A retrospective review of radiological examinations suggested that LECs have a relatively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear more common in elderly males, and are typically incidental, large, unilocular cysts. Close attention to signal intensity on MRI may allow preoperative diagnosis of these lesions. | Julie Martin Keith J Roberts Maria Sheridan Gavin A Falk Daniel Joyce R Matthew Walsh Andrew M Smith Gareth Morris-Stiff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 1 |
| 17 | Exploiting Contextual Change in Context-Aware Retrieval显示文摘 | Peter J Brown Gareth J F Jones | 2002 | ACM2002，23，8： | 1 |
| 18 | Systems for monitoring corrosion in new and existing structures显示文摘 | GARETH J | 1996 | Construction Repair1996，10，6： | 1 |
| 19 | Pica-a model of nausea? Species differences in response to cisplatin 显示文摘 | Yong-Liug Liu Nasser Malik Gareth J S | 2005 | Physiology &Behavior2005，85，： | 1 |
| 20 | Exploiting Contextual Change in Context-Aware Retrieval显示文摘 | PETER J BROWN GARETH J F JONES | 2002 | ACM 1-58113-445-2/02/032002，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员