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| 1 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 2 | 高通量天然产物化学和毛细管核磁共振探头技术的应用显示文摘介绍了近几年为高通量药物筛选构建大型天然产物样品库的高通量天然产物化学,即多通道平行高效液相制备和平行液质联用分析技术;详细介绍了核磁共振新技术即体积小和质量灵敏度高的毛细管核磁共振探头技术,该探头技术的成功应用使得天然产物样品库中活性化合物的结构鉴定所需样品量降低到前所未有的微克级水平;展望了源于中药的天然产物作为小分子探针开展脑功能方面的化学基因组学研究。 | 胡金锋 Gary R.Eldridge 余亦华 Mark O'Neil-Johnson | 2008 | 化学进展2008，20，4： | 6 |
| 3 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 4 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 5 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 6 | Morbidity and Mortality Analysis of 200 Treatments With Cytoreductive Surgery and Hyperthermic Intraoperative Intraperitoneal Chemotherapy Using the Coliseum Technique显示文摘 | Arvil D. Stephens MD Robert Alderman PA-C David Chang MD Gary D. Edwards PA-C Jesus Esquivel MD Gilbert Sebbag MD Mark A. Steves MD Paul H. Sugarbaker MD | 1999 | Annals of Surgical Oncology1999，，8： | 5 |
| 7 | Intermediate results of a prospective randomized controlled trial of traditional four-port laparoscopic cholecystectomy versus single-incision laparoscopic cholecystectomy显示文摘 | Melissa Phillips Jeffrey Marks Kurt Roberts Roberto Tacchino Raymond Onders George DeNoto Homero Rivas Arsalla Islam Nathaniel Soper Gary Gecelter Eugene Rubach Paraskevas Paraskeva Sajani Shah | 2012 | Surgical Endoscopy2012，，5： | 4 |
| 8 | HFC-245fa性质及应用综述显示文摘HFC-245fa是近年来发展起来的一种碳氟氢化合物,它在发泡剂、溶剂、气溶胶及制冷设备工质等领域有着广阔的应用前景。本文回顾了美国环保署(EPA)对HFC-245fa各种应用的批准使用情况。由于具备良好的热物理特性,HFC-245fa在导热和制冷设备工质中有很多应用。文中总结了HFC-245fa的热物理特性,并根据几个实例对HFC-245fa的各种应用进行了讨论,包括在离心式冷冻器、有机兰金循环(Or-ganicRankineCycle)中的能源再生、低温制冷中的显热转换以及被动式冷却设备中的应用等。此外,还讨论了HFC-245fa的热稳定性、化学稳定性及其和建筑材料的相容性,并介绍了迄今为止所进行的一些热、化学稳定性测试及测试结果。讨论还涉及了金属、工程塑料、人造橡胶等几种普通建筑材料对HFC-245fa的可接收性。关于使用HFC-245fa可能带来的健康、安全和环境问题,如毒性、相关部门的参考使用暴露极限值、易燃性。此外对臭氧层的破坏、对全球变暖趋势的影响以及产品的安全管理等,文章也进行了相应的介绍。 | Gary J.Zyhowski Sr. Mark W.Spatz Samuel Yana Motta 张社 | 2003 | 家电科技2003，，8： | 4 |
| 9 | A Systematic Review of Factors That Contribute to Hepatosplenic T-Cell Lymphoma in Patients With Inflammatory Bowel Disease显示文摘 | David S. Kotlyar Mark T. Osterman Robert H. Diamond David Porter Wojciech C. Blonski Mariusz Wasik Sami Sampat Manuel Mendizabal Ming V. Lin Gary R. Lichtenstein | 2011 | Clinical Gastroenterology and Hepatology2011，，1： | 3 |
| 10 | A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block显示文摘Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1]. | Alex Tsz Lai Nganh Sharen Lee Tong LIU Mark Tam Ka Hou Christien Li Michelle Vangi Wong Michael Huen Sum Lam Gary Tse Ishan Lakhani | 2019 | Journal of Geriatric Cardiology2019，16，1： | 2 |
| 11 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 12 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 13 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford M.D. John Kilkenny M.D. Neil Hyman M.D. W. Donald Buie M.D. Jeffrey Cohen M.D. Charles Orsay M.D. Gary Dunn M.D. W. Brian Perry M.D. C. Neal Ellis M.D. Jan Rakinic M.D. Sharon Gregorcyk M.D. Paul Shellito M.D. Richard Nelson M.D. Joe J. | 2005 | Diseases of the Colon & Rectum2005，，7： | 2 |
| 14 | Temperature-insensitive near-infrared spectro scopic measurement of glucose in aqueous solutions显示文摘 | Hazen Kevin H Arnold Mark A Small Gary W | 1994 | Applied Spectroscopy1994，48，4： | 1 |
| 15 | Acute Heart Failure Syndromes: Emergency Department Presentation, Treatment, and Disposition: Current Approaches and Future Aims: A Scientific Statement From the American Heart Association显示文摘 | Neal L. Weintraub Sean P. Collins Peter S. Pang Phillip D. Levy Allen S. Anderson Cynthia Arslanian-Engoren W. Brian Gibler James K. McCord Mark B. Parshall Gary S. Francis Mihai Gheorghiade | 2010 | Circulation2010，，： | 1 |
| 16 | Computational slrategies for nonlinear and fracture mechanics problems: automatic crack propagation tracking显示文摘 | Mark S Shephard Nabil A B Yehia Gary S Burd | 1985 | Computer & Structure1985，20，： | 1 |
| 17 | Near-infrared spectroscopic measurement of glucose in a protein matrix显示文摘 | Marquardt Lois A Arnold Mark A Small Gary W | 1993 | Anal Chem1993，65，： | 1 |
| 18 | Structure and dynamics of water near the interface with oligo(ethylene oxide) self-assembled monolayers显示文摘 | Ahmed E I Gary S G Mark J S | 2007 | Langmuir2007，23，： | 1 |
| 19 | Primary Aortoenteric Fistula: Computed Tomographic Diagnosis of an Atypical Presentation显示文摘 | James T. Lee R. Mark Saroyan Gary Belzberg Nana A. Pianim Fred S. Bongard | 2001 | Annals of Vascular Surgery2001，，2： | 1 |
| 20 | Examining the value of pharmacy benefit management companies显示文摘 | Garis Robert I Clark Bartholomew E Siracuse Mark V | 2004 | American Journal of Health-System Pharma- cy2004，，61： | 1 |
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