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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 5 | papillary thyroid mierocarcinoma: A surgical perspective 显示文摘 | Sakorfafas GH Giotakis J Stafyla V | 2005 | Cancer Treat Rev2005，31，6： | 1 |
| 6 | DNA typing of HLA-B alleles: comparison of PCR-SSOP and PCRcloning-sequencing显示文摘 | Nielsen J Shi XJ Zhang GH | 1996 | Hum Immunol1996，，： | 1 |
| 7 | Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘 | D'ANGELO J G BORD N C POSNER GH | 2009 | J Antimicrob Chemother2009，63，1： | 1 |
| 8 | Guidelines for using the Quan- tiFERON-TB-Glod test for detecting Mycobacterium tuberculosis infection, United states显示文摘 | Mazurek GH Jereb J Lobue P | 2005 | MMWR Recomm Rep2005，54，15： | 1 |
| 9 | Cerebral blood flow in relation to contralateral carotid disease,an MRA and TCD study显示文摘 | de Nie A J Blankensteijn JD Visser GH | 2001 | Eur J Vasc Endovasc Surg2001，21，3： | 1 |
| 10 | The clinical signi ficance of axillary lymph node micrometastases in breast cancer显示文摘 | Sakorafas GH Geraghty J Pavlakis G | 2004 | Eur J Surg Oncol2004，30，8： | 1 |
| 11 | Rise in serum soluble intercellular adhesion molecule-1 levels with vasospasm following aneurysmal subarachnoid hemorrhage显示文摘 | Mocco J Mack WJ Kim GH | 2002 | Neurosurgery2002，97，3： | 1 |
| 12 | The role of acid and duodenal gastrophageal refluxin symptomatic GERD 显示文摘 | Koek GH Tack J Sifrim D | 2001 | Am Gastroenterof2001，96，： | 1 |
| 13 | Treatment of upper urinary cal- culi with the PCNL technique (Experience of 20 years)显示文摘 | Li X Zeng GH Yuan J | 2004 | Beijing Da Xue Xue tMo2004，36，2： | 1 |
| 14 | Grades of Recommendation for Antithrombotic Agents显示文摘 | Guyatt GH Cook D J Jaeschke R | 2008 | Chest2008，133，： | 1 |
| 15 | Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 显示文摘 | Liu GH Qu J Suzuki K | 2012 | Nature2012，491，7425： | 1 |
| 16 | Hyper homocysteinemia and its role in the development of artehrosclerosis显示文摘 | Lawrence de Koning AB Weratuck GH Zhou J | 2003 | Clin Biochen2003，36，6： | 1 |
| 17 | Cloning and characterization of ZNF 189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31 显示文摘 | Odeberg J Rosok O Gudmundsson GH | 1998 | Genomics1998，50，2： | 1 |
| 18 | Bad bugs need drugs, an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America显示文摘 | Talbot GH Bradley J Edwards JE | 2006 | Clin Infect Dis2006，42，5： | 1 |
| 19 | Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells显示文摘 | Wang Y Ripperger J Fey GH | 1999 | Hepatology1999，30，3： | 1 |
| 20 | Complete nucleotide sequence and taxonomy of sugarcane streak mosaic virus, member of a novel genus in the family Potyviridae显示文摘 | Xu DL Zhou GH Xie Y J Mock R LiR | 2010 | Virus Genes2010，40，3： | 1 |
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