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| 1 | Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis显示文摘AIM:To evaluate the clinical significance of-765G/C and-1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).METHODS:The study included 201 patients:85 with PC and 116 healthy controls.-765G/C and-1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood samples.The associations of the analyzed genotypes and clinical data at diagnosis were evaluated.RESULTS:We found an increased frequency of the homozygous-1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P < 0.01).In contrast,the distribution of genotypeand allele frequencies of the-765G/C COX-2 polymorphism in the PC patients were not different from those in control groups.A correlation between presence of homozygous-1195AA COX-2 genotype and tumor size > 3 cm was observed (P < 0.05).Analyzed polymorphisms were unrelated to the patients' sex and age,nor to the presence of regional or distant metastases.CONCLUSION:These preliminary results indicate that the-1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis. | Renata Talar-Wojnarowska Anita Gasiorowska Marek Olakowski Pawel Lampe Beata Smolarz Hanna Romanowicz-Makowska Ewa Malecka-Panas | 2011 | World Journal of Gastroenterology2011，17，36： | 4 |
| 2 | Tumor necrosis factor alpha and interferon gamma genes polymorphisms and serum levels in pancreatic adenocarcinoma显示文摘 | Talar - Wojnarowska R Gasiorowska A Smolarz B | 2009 | Neoplasma2009，56，1： | 1 |
| 3 | Interaction ofnitric oxide and the cytochrome P-450 system on blood pressureand renal function in the rat:dependence on sodium intake显示文摘 | Kuczeriszka M Olszyński KH Gasiorowska A | 2011 | Acta Physiol2011，201，： | 1 |
| 4 | Vitamin C and quercetin modulate DNA damaging effect of N-methyl-n'-nitro- n-nitrosoguanidine (MNNG)显示文摘 | Blasiak J Trzeciak A Gasiorowska A | 2002 | Plant Food Hum Nutr2002，57，1： | 1 |
| 5 | Clinical value of serum neopterin, tissue polypeptide-specific antigen and CA19-9 levels in differential diagnosis between pancreatic cancer and chronic pancreatitis 显示文摘 | Talar-Wojnarowska R Gasiorowska A Olakowski M | 2010 | Pancreatology2010，10，6： | 1 |
| 6 | Endocrine pancreatic function in patients after acute pancreatitis 显示文摘 | Malecka-Panas E Gasiorowska A Kropiwnicka A | 2002 | Hepatogastroenterology2002，49，： | 1 |
| 7 | Refractory GERD: What is it?显示文摘 | Ronnie Fass Anita Gasiorowska | 2008 | Current Gastroenterology Reports2008，，3： | 1 |
| 8 | The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon显示文摘 | Neneman B Gasiorowska A Malecka-Panas E | 2006 | Adv Med Sci2006，51，1： | 1 |
| 9 | Refractory GERD:what is it? 显示文摘 | Fass R Gasiorowska A | 2008 | Curt Gastroenterol Rep2008，10，3： | 1 |
| 10 | Prognostic factors in the operative and palliative treatment of pancreatic cancer显示文摘 | Talar-Wojnarowska R Gasiorowska A Strzelczyk J | 2003 | Neoplasma2003，50，5： | 1 |
| 11 | The efficacy and safety of argon plasma coagulation(APC)in the management of polyp remnants in stomach and colon显示文摘 | Neneman B Gasiorowska A Ma ecka-Panas E | 2006 | Adv Med Sci2006，51，1： | 1 |
| 12 | Utility of different serum fibrosis markers in diagnosing patients with chronic pancreatitis and pancreatic adenocarcinoma显示文摘AIM: To estimate the levels of serum cytokines in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC) patients in order to evaluate their usefulness as possible biomarkers.METHODS: The study included 167 Caucasian patients: 74 with PDAC(28 men and 42 women, aged 30-88 years), 78 with CP(50 men and 21 women, aged 20-79 years) and 15 age-matched healthy controls hospitalized in the Department of Digestive Tract Diseases, Medical University of Lodz, Poland between 2006 and 2013. Serum MCP-1, transforming growth factor(TGF)-β1, HA and s-Fr were measured in patients with CP(n = 78), PDAC(n = 74) and healthy controls(n = 15) using ELISA(Corgenix United Kingdom Ltd R and D Systems). The severity of CP was assessed according to the Cambridge classification.RESULTS: Both patients with CP and PDAC had a significantly higher mean TGF-β1 serum level(1066 ± 582and 888 ± 356 vs 264 ± 93, P < 0.0001), mean s-Fr(2.42 ± 1.385 and 2.41 ± 1.275 vs 0.6 ± 0.370, P < 0.0001) and mean HA(199 ± 254 and 270 ± 358 vs 40 ± 26, P < 0.0001) compared to controls. There was no difference in mean MCP-1 between all the groups. There were no significant differences in any cytokine levels between the PC and PDAC groups. No significant differences between serum cytokines depending on age, gender or smoking status were found in CP patients. Mean s-Fr concentration was significantly higher in CP, lasting longer than 5 years compared to those with a shorter disease clinical course(2.639 ± 1.125 vs 1.870 ± 0.970, P < 0.03). There was no correlation between tumor size, localization or TNM classification and serum TGF-β1, MCP-1, s-Fr and HA levels in patients with PDAC. No significant differences between cytokines depending on diabetes presence in CP were found. Nevertheless, mean serum TGF-β1 concentration in PDAC patients was higher in those with diabetes compared to the remaining group(986 vs 839, P = 0.043). CONCLUSION: Serum TGF-β1, s-Fr and HA may be considered additional diagnostic markers of CP and PDAC. TGF-β1 may be useful to predict endocrine insufficiency in PDAC. | Anna Kozak Renata Talar-Wojnarowska Aleksandra Kaczka Anna Borkowska Leszek Czupryniak Ewa Malecka-Panas Anita Gasiorowska | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 1 |
| 13 | Clinical sig- nificance of interleukin - 6 ( IL - 6 ) gene Polymorphism and IL - 6 se- rum level in Pancreatic adenocarcinoma and chronic Pancreatitis显示文摘 | Talar - Wojnarowska R Gasiorowska A Smolarz B | 2009 | Dis Dis Sci2009，54，3： | 1 |
| 14 | Vitamin C and quercetin modulate DNA - damaging effect of N - methyl - N'nitro- N - nitrosoguanidine(MNNG)显示文摘 | Blasiak J Trzeciak A Gasiorowska A | 2002 | Plant Foods Hum Nutr2002，57，1： | 1 |
| 15 | Usefulness of p16 and K-ras mutation in pancreatic adenocar- cinoma and chronic pancreatitis differential diagnosis 显示文摘 | Talar-Wojnarowska R Gasiorowska A Smolarz B | 2004 | J Physiol Pharmacol2004，552，： | 1 |
| 16 | Clinical significance of interleukin-6 (IL-6) gene polymorphism and IL-6 serum level in pancreatic adenocarcinoma and chronic pancreatitis 显示文摘 | Talar-Wojnarowska R Gasiorowska A Smolarz B Romanowicz- Makowska H Kuliq A Malecka-Panas E | 2009 | Dig Dis Sci2009，54，3： | 1 |
| 17 | The efficacy and safety of argon plasma coagulation(APC)in the management of polyp remnants in stomach and colon显示文摘 | NENEMAN B GASIOROWSKA A MALECKA-PANAS E | 2006 | Adv Mad Sci2006，51，1： | 1 |
| 18 | Clinical value of serum neopterin,tissue polypeptide-specific antigen and CA199 levels in differential diagnosis between pancreatic cancer and chronic pancreatitis显示文摘 | Talar-Wojnarowska R Gasiorowska A Olakowski M | 2010 | Pancreatology2010，10，6： | 1 |
| 19 | Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer显示文摘 | Bombski G Gasiorowska A Orszulak-Michalak D | 2002 | Int J Gastrointest Cancer2002，31，13： | 1 |
| 20 | The efficacy and safety of argon plasma coagulation (APC)in the management of polyp remnants in stomach and colon 显示文摘 | NENEMAN B GASIOROWSKA A MALECKA- PANAS E | 2006 | Adv Med Sci2006，51，1： | 1 |
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