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| 1 | Crohn's disease and growth deficiency in children and adolescents显示文摘Nutritional concerns, linear growth deficiency, and delayed puberty are currently detected in up to 85% of patients with Crohn's disease(CD) diagnosed at childhood. To provide advice on how to assess and manage nutritional concerns in these patients, a Medline search was conducted using 'pediatric inflammatory bowel disease', 'pediatric Crohn's disease', 'linear growth','pubertal growth', 'bone health', and 'vitamin D' as key words. Clinical trials, systematic reviews, and metaanalyses published between 2008 and 2013 were selected to produce this narrative review. Studies referring to earlier periods were also considered if the data was relevant to our review. Although current treatment strategies for CD that include anti-tumor necrosis factor-αtherapy have been shown to improve patients' growth rate, linear growth deficiencies are still common. In pediatric CD patients, prolonged diagnostic delay, high initial activity index, and stricturing/penetrating typeof behavior may cause growth deficiencies(in weight and height) and delayed puberty, with several studies reporting that these patients may not reach an optimal bone mass. Glucocorticoids and inflammation inhibit bone formation, though their impact on skeletal modeling remains unclear. Long-term control of active inflammation and an adequate intake of nutrients are both fundamental in promoting normal puberty. Recent evidence suggests that recombinant growth factor therapy is effective in improving short-term linear growth in selected patients, but is of limited benefit for ameliorating mucosal disease and reducing clinical disease activity. The authors conclude that an intense initial treatment(taking a 'top-down' approach, with the early introduction of immunomodulatory treatment) may be justified to induce and maintain remission so that the growth of children with CD can catch up, ideally before puberty. Exclusive enteral nutrition has a key role in inducing remission and improving patients' nutritional status. | Marco Gasparetto Graziella Guariso | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 2 | A Mechanical Model for the Adhesion of Spiders to Nominally Flat Surfaces显示文摘In dry attachment systems of spiders and geckos, van der Waals forces mediate attraction between substrate and animaltarsus. In particular, the scopula of Evarcha arcuata spiders allows for reversible attachment and easy detachment to a broadrange of surfaces. Hence, reproducing the scopula’s roughness compatibility while maintaining anti-bunching features and dirtparticle repellence behavior is a central task for a biomimetic transfer to an engineered model. In the present work we model thescopula of E. arcuata from a mechano-elastic point of view analyzing the influence of its hierarchical structure on the attachmentbehavior. By considering biological data of the gecko and spider, and the simulation results, the adhesive capabilities of thetwo animals are compared and important confirmations and new directives in order to reproduce the overall structure are found.Moreover, a possible suggestion of how the spider detaches in an easy and fast manner is proposed and supported by the results. | Alessandro Gasparetto Tobias Seidl Renato Vidoni | 2009 | Journal of Bionic Engineering2009，6，2： | 5 |
| 3 | Treating children with inflammatory bowel disease: Current and new perspectives显示文摘Inflammatory bowel disease(IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A MEDLINE search was conducted using 'paediatric inflammatory bowel disease', 'paediatric Crohn's disease', 'paediatric ulcerative colitis', 'treatment', 'therapy', 'immunosuppressant', 'biologic', 'monitoring' and 'biomarkers' as key words. Clinical trials, systematic reviews, and meta-analyses published between 2014 and 2016 were selected. Studies referring to earlier periods were also considered in case the data was relevant to our scope. Major advances have been achieved in monitoring the individual metabolism, toxicity and response to relevant medications in IBD including thiopurines and biologics. New biologics acting on novel mechanisms such as selective interference with lymphocyte trafficking are emerging treatment options. Current research is investing in the development of reliable prognostic biomarkers, aiming to move towards personalised treatments targeted to individual patients. | Graziella Guariso Marco Gasparetto | 2017 | World Journal of Gastroenterology2017，23，30： | 5 |
| 4 | Feasibility study of computed vs measured high b-value(1400 s/mm2) diffusion-weighted MR images of the prostate显示文摘AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system.For DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P < 0.001; 5.6 ± 1.8 vs 2.8 ± 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONCLUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting. | Leonardo K Bittencourt Ulrike I Attenberger Daniel Lima Ralph Strecker Andre de Oliveira Stefan O Schoenberg Emerson L Gasparetto Daniel Hausmann | 2014 | World Journal of Radiology2014，6，6： | 5 |
| 5 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 6 | Optimal trajectory planning for industrial robots显示文摘 | A. Gasparetto V. Zanotto | 2009 | Advances in Engineering Software2009，，4： | 2 |
| 7 | Optimal Trajectory Planning for Industrial Robots显示文摘 | Gasparetto A Zanotto V | 2010 | Advances in Engineering Software2010，41，4： | 1 |
| 8 | Pineal yolk sac tumor:correlation between neuroimaging and pathological findings显示文摘 | Davaus T Gasparetto E L Carvalho Neto A | 2007 | Arq Neuropsiquiatr2007，65，2： | 1 |
| 9 | Pereutaneous vertebroplasty for vertebral osteoporotic f ractures:long term analysis显示文摘 | Marchiori E Gasparetto EL | 2007 | ArqNeuropsiquiatr2007，65，4： | 1 |
| 10 | An electrophysio- logical study of the intermediate syndrome of organophos- phate poisoning显示文摘 | Lorenzoni PJ Gasparetto J Kay CS | 2010 | J Clin Neurosci2010，17，9： | 1 |
| 11 | Development and validation of an HPLC - DAD method for analysis of the six major isofla- vones in extracts from soybean processing 显示文摘 | Gasparetto J C Smolarek F S F De Francisco | 2012 | J Am Oil Chem Soc2012，89，7： | 1 |
| 12 | Percutaneous vertebroplasty for vertebral osteoporotic fractures: long term analysis 显示文摘 | Astacio GS Marchiori E Gasparetto EL | 2007 | Arq neuropsiquiatr2007，65，： | 1 |
| 13 | Funcional perfusion and BBB permeability images in the diagnosis of cerebral tumors by angio CT显示文摘 | Bartolini A Gasparetto B Furlan M | 1994 | Comput Med Imaging Graph1994，18，： | 1 |
| 14 | Efficient Force Distribution and Leg Posture for A Bin-inspired Spider Robot 显示文摘 | R Vidoni A Gasparetto | 2011 | Robotics and Autonomous Systems (S0921-8890)2011，59，2： | 1 |
| 15 | Nonalcoholic Wernicke enceph- alopathy with extensive cortical involvement: cortical laminar necrosis and hemorrhage demonstrated With susceptibility-weighted MR phase images显示文摘 | creira DB Pereira ML Gasparetto EL | 2011 | AJNR Am J Neuroradiol2011，32，2： | 1 |
| 16 | Model-based trajectory planning for flexible-link mechanisms with bounded jerk显示文摘 | P. Boscariol A. Gasparetto | 2012 | Robotics and Computer Integrated Manufacturing2012，，： | 1 |
| 17 | Immune activation as effect modifier of atherogenesis in chronic infection 显示文摘 | Ricevuti G Grini D Gasparetto C | 2002 | Int Rev Immunol2002，21，1： | 1 |
| 18 | Cytomegalovirus pneumonia after bone marrow transplantation: high resolution CT findings 显示文摘 | Gasparetto EL Ono SE Escuissato D | 2004 | Br J Radiol2004，77，921： | 1 |
| 19 | Efficient force distribution and leg posture for a bio-inspired spider robot显示文摘 | Vidoni R Gasparetto A | | 0，，02： | 1 |
| 20 | Haemangioblastomas: Clinical, epidemiological and pathological findings in 14 cases显示文摘 | Gasparetto EL Faoro LN Reis Filho JS | 2000 | Arq Neuropsiquiatr2000，58，2： | 1 |
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