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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome. | Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 6 |
| 3 | Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis显示文摘Background: Gold standard for colorectal liver metastases(CRLM) remains hepatic resection(HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation(MWA), radiofrequency ablation(RFA) and HR by conducting the first network meta-analysis. Data sources: Systematic search of the literature was conducted in the electronic databases. Both updated traditional and network meta-analyses were conducted and the results were compared between them. Results: HR cohort demonstrated significantly less local recurrence rate and better 3-and 5-year diseasefree(DFS) and overall survival(OS) compared to MWA and RFA cohorts. HR cohort included significantly younger patients and with significantly lower preoperative carcinoembryonic antigen(CEA) by 10.28 ng/m L compared to RFA cohort. Subgroup analysis of local recurrence and OS of solitary and ≤3 cm CRLMs did not demonstrate any discrepancies when compared with the whole sample. Conclusions: For resectable CRLM the treatment of choice still remains HR. MWA and RFA can be used as a single or adjunct treatment in patients with unresectable CRLM and/or prohibitive comorbidities. | Paschalis Gavriilidis Keith J Roberts Nicola de’Angelis Luca Aldrighetti Robert P Sutcliffe | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 4 | Simultaneous portal and hepatic vein embolization is better than portal embolization or ALPPS for hypertrophy of future liver remnant before major hepatectomy: A systematic review and network meta-analysis显示文摘Background:Post-hepatectomy liver failure(PHLF)is the Achilles’heel of hepatic resection for colorectal liver metastases.The most commonly used procedure to generate hypertrophy of the functional liver remnant(FLR)is portal vein embolization(PVE),which does not always lead to successful hypertrophy.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been proposed to overcome the limitations of PVE.Liver venous deprivation(LVD),a technique that includes simultaneous portal and hepatic vein embolization,has also been proposed as an alternative to ALPPS.The present study aimed to conduct a systematic review as the first network meta-analysis to compare the efficacy,effectiveness,and safety of the three regenerative techniques.Data sources:A systematic search for literature was conducted using the electronic databases Embase,PubMed(MEDLINE),Google Scholar and Cochrane.Results:The time to operation was significantly shorter in the ALPPS cohort than in the PVE and LVD cohorts by 27 and 22 days,respectively.Intraoperative parameters of blood loss and the Pringle maneuver demonstrated non-significant differences between the PVE and LVD cohorts.There was evidence of a significantly higher FLR hypertrophy rate in the ALPPS cohort when compared to the PVE cohort,but non-significant differences were observed when compared to the LVD cohort.Notably,the LVD cohort demonstrated a significantly better FLR/body weight(BW)ratio compared to both the ALPPS and PVE cohorts.Both the PVE and LVD cohorts demonstrated significantly lower major morbidity rates compared to the ALPPS cohort.The LVD cohort also demonstrated a significantly lower 90-day mortality rate compared to both the PVE and ALPPS cohorts.Conclusions:LVD in adequately selected patients may induce adequate and profound FLR hypertrophy before major hepatectomy.Present evidence demonstrated significantly lower major morbidity and mortality rates in the LVD cohort than in the ALPPS and PVE cohorts. | Paschalis Gavriilidis Gabriele Marangoni Jawad Ahmad Daniel Azoulay | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，3： | 2 |
| 5 | Functional study of transcription factor KLF11 by targeted gene inactivation显示文摘 | SONG C Z GAVRIILIDIS G ASANO H | 2005 | Blood Cells Mol Dis2005，34，1： | 1 |
| 6 | Catalyst Preparation and Deactivation Issues for Nitrobenzene Hydrogenation in a Microstructured Falling Film Reactor显示文摘 | Gavriilidis A Zapf R | 2003 | Catal Today2003，，81： | 1 |
| 7 | 显示文摘 | Zanfir M Gavriilidis A | 2001 | Chemical Engineering Science2001，56，8： | 1 |
| 8 | Catalyst preparation and deactivation issues for nitrobenzene hydrogenation in a micro-structured falling film reactor 显示文摘 | YEONG K K GAVRIILIDIS A ZAPF R | 2003 | Catal Tod2003，81，4： | 1 |
| 9 | Design and characterisation of the staggered herringbone mixer 显示文摘 | KEE S P GAVRIILIDIS A | 2008 | Chemical Engineering Journal2008，142，1： | 1 |
| 10 | Flow regimes for adia- batic gas - liquid flow in microchannels 显示文摘 | Gavriilidis A Shao N Angeli P | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 11 | Oxidative dehydro- genation of 3-methyl-2-buten-l-ol in microreactors显示文摘 | Cao E Gavriilidis A Motherwell W B | 2004 | Chemi cal Engineering Science2004，59，2004： | 1 |
| 12 | A model for predicting axial mix- ing during gas-liquid Taylor flow in microchannels at low Bodenstein numbers 显示文摘 | Salman W Gavriilidis A Angeli P | 2004 | Chem Eng J2004，101，123： | 1 |
| 13 | Effect of drying conditions of Au-Mn Co-Precipitates for low-temperature CO oxidation 显示文摘 | Seung-Jae Lee Asterios Gavriilidis Quentin A | 2001 | J Catal2001，200，2： | 1 |
| 14 | CFD simulations of the effect of inlet conditions on Taylor flow formation 显示文摘 | Shao N Sahnan W Gavriilidis A | 2008 | International Journal of Heat and Fluid Flow2008，29，6： | 1 |
| 15 | Gas-liquid and gas- liquid-solid microstructured reactors: Contacting principles and applications 显示文摘 | Hessel V Angeli P Gavriilidis A | 2005 | Ind Eng Chem Res2005，44，25： | 1 |
| 16 | Design and fabrication of zeolite-based microreactors and membrane microseparators 显示文摘 | Wan Y S S Chau J L H Gavriilidis A Yeung K L | 2001 | Micreporeus Mesoporous Materials2001，42，23： | 1 |
| 17 | Flow distribution in different microreactor scale-out geometries and the effect of manufacturing tolerances and channel blockage 显示文摘 | Amador C Gavriilidis A Angeli P | 2004 | Chemical Engineering Journal2004，101，1： | 1 |
| 18 | 显示文摘 | Zanfir M Gavriilidis A | 2002 | Chemical Engineering Journal2002，86，3： | 1 |
| 19 | TS-1 oxidation of aniline to azoxybenzene in a micmstructured reactor 显示文摘 | Wan Y S S Yeung K L Gavriilidis A | 2005 | Applied Catalysis A: General2005，281，12： | 1 |
| 20 | Modelling of a catalytic plate reactor for dehydrogenation- combustion coupling显示文摘 | Gavriilidis A | 2001 | Chem Eng Sci2001，56，8： | 1 |
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