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| 1 | Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier显示文摘Androgen deprivation therapy(ADT)has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer(PCa).However,this approach is rarely curative.Recent clinical trials have demonstrated that ADT combined with other agents,notably docetaxel and abiraterone,lead to improved survival.The mechanisms surrounding this improved cancer outcomes are incompletely defined.The response of cancer cells to ADT includes apoptosis and cell death,but a significant fraction remains viable.Our laboratory has demonstrated both in vitro and in vivo that cellular senescence occurs in a subset of these cells.Cellular senescence is a phenotype characterized by cell cycle arrest,senescenceassociated b-galactosidase(SA-b-gal),and a hypermetabolic state.Positive features of cellular senescence include growth arrest and immune stimulation,although persistence may release cytokines and growth factors that are detrimental.Senescent tumor cells generate a catabolic state with increased glycolysis,protein turnover and other metabolic changes that represent targets for drugs,like metformin,to be applied in a synthetic lethal approach.This review examines the response to ADT and the putative role of cellular senescence as a biomarker and therapeutic target in this context. | Tyler Etheridge Shivashankar Damodaran Adam Schultz Kyle A.Richards Joseph Gawdzik Bing Yang Vincent Cryns David F.Jarrard | 2019 | Asian Journal of Urology2019，6，1： | 3 |
| 2 | Methane separation from coalmine methane gas by vacuum pressure swing adsorption 显示文摘 | Olajossy A Gawdzik A | 2003 | Institution of Chemi- cal Engineers2003，81，4： | 1 |
| 3 | Kinetic model for the process giving linear polyurethanes, with consideration of substi- tution effects and different chemical reactivities of func- tional groups in 2,4-diisocyanate显示文摘 | KROL P GAWDZIK A | 1995 | Journal of Applied Polymer Science1995，58，： | 1 |
| 4 | Modification of Unsaturated Polyester Resin with Bismaleimide显示文摘 | GAWDZIK B MATYNIA T CHMIELEWSKA E | 2001 | J Appl Polym Sci2001，81，8： | 1 |
| 5 | Methane Separation from Coal Mine Methane Gas by Vacuum Pressure Swing Adsorption显示文摘 | A. Olajossy A. Gawdzik Z. Budner J. Dula | 2003 | Chemical Engineering Research and Design2003，，4： | 1 |
| 6 | , Vascular remodeling and arterial calcification are directly mediated by S100A12 (EN-RAGE) in chronic kidney disease显示文摘 | Gawdzik J Mathew L Kim G | 2011 | Am J Nephrol2011，33，3： | 1 |
| 7 | Chemical modification of the polymeric soybent containing hydroxyl functional groups显示文摘 | Gawdzik B Matynia T | 1997 | Chromatographia1997，44，12： | 1 |
| 8 | 8100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program显示文摘 | Hofmann Bowman M A Gawdzik J Bukhari U | 2011 | Arterioscler Thromb Vasc Biol2011，31，2： | 1 |
| 9 | S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program显示文摘 | Hofmann BMA Gawdzik J Bukhari U | | 0，，： | 1 |
| 10 | S100A12 expression in thoracic aortic aneurysm is associated with increased risk of dissection and perioperative complications显示文摘 | Das D Gawdzik J Dellefave-Castillo L | | 0，，： | 1 |
| 11 | Phosporicacid activation functionalization and porosity modification显示文摘 | A M PUZIY O I PODDUBNAYA B GAWDZIK | 2007 | Applied Surface Science2007，253，： | 1 |
| 12 | Vascular remodeling and arte-rial calcification are directly mediated by S100A12(EN-RAGE) in chronic kidney disease显示文摘 | Gawdzik J Mathew L Kim G | | 0，，： | 1 |
| 13 | Methane separation from coal mine methane gas by vacuum pressure swing adsorption显示文摘 | OLAJOSSY A GAWDZIK A BUDNER Z | 2003 | Chemical Engineering Research and Design2003，81，4： | 1 |
| 14 | Vascular remod- eling and arterial calcification are directly mediated by S100A12 (EN-RAGE) in chronic kidney disease 显示文摘 | GAWDZIK J MATHEW L KIM G | 2011 | Am J Nephrol2011，33，3： | 1 |
| 15 | Methane separation from coal mine methane gas by vacuum pressure swing adsorption显示文摘 | Olajossy A Gawdzik A Budner Z | 2003 | Chemical Engineering Research and Design2003，81，4： | 1 |
| 16 | Metnane separation from coal mine methane gas by vacuum pressure swing adsorption显示文摘 | Olajossy A Gawdzik A Budner Z | 2003 | Institution of Chemical Engineers2003，81，4： | 1 |
| 17 | Methane separation from eoalmine methane gas by vacuum pressure swing adsorption显示文摘 | Olajossy A Gawdzik A | 2003 | Institution of Chemical Engineers2003，81，4： | 1 |
| 18 | Analysis of structure and properties of active carbons and their copolymeric precursors 显示文摘 | Sobiesiak M Gawdzik B Puziy A M | 2010 | Applied Surface Science2010，256，： | 1 |
| 19 | Transgenic expression of human S100A12 induces struc- tural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation显示文摘 | Hofmann Bowman MA Heydemann A Gawdzik J | 2011 | Clin Exp Allergy2011，41，6： | 1 |
| 20 | Synthesis of Aromatic Polycarbonates from Bisphenol A, Phenol and Dimethyl Car- bonate显示文摘 | Tkacz B Grzywa E Gawdzik A | 2003 | Przem Chem2003，82，89： | 1 |
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