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| 1 | Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis显示文摘OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract.METHODS: Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy(AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis.RESULTS: Curcumin and K. senegalensis increased the cell stiffness by 2.6-and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox(glutathione level) and energy(adenosine triphosphate) status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition, the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay.CONCLUSION: Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells. | Jeremiah Olorunjuwon Olugbami Robert Damoiseaux Bryan France Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 2 | Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible显示文摘 | Hinkes B Wiggins R C Gbadegesin R Vlangos C N Seelow D Nurnberg G | 2006 | Nat Genet2006，38，： | 1 |
| 3 | Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid -dependent nephrotie syndrome显示文摘 | Gbadegesin R Hinkes B Vlangos C | 2007 | Pediatr Nephrol2007，22，4： | 1 |
| 4 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS) 显示文摘 | Gbadegesin R Hinkes B G Hoskins B E Vlangos C N Heerin ga S F Liu J | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 5 | Positional cloning uncovers mutations in PLCE1 responsible for a nephritic syndrome variant that may be reversible 显示文摘 | Hinkes B Wiggins RC Gbadegesin R | 2006 | Nat Genet2006，38，12： | 1 |
| 6 | Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS 显示文摘 | Gbadegesin R Bartkowiak B Lavin PJ | 2009 | Pediatr Nephrol2009，24，2： | 1 |
| 7 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (DMS) 显示文摘 | Gbadegesin R Hinkes BG Hoskins BE | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
| 8 | Avoiding the mistakes of the past:towards a community oriented management strategy for the proposed national park in Abuja-Nigeria显示文摘 | Gbadegesin A Ayileka O | 2000 | Land Use Policy2000，17，2： | 1 |
| 9 | Positional cloning uncovers mutations in PLCE1 responsible for a nephritic syndrome variant that may be reversible 显示文摘 | Hinkes B Wiggins RC Gbadegesin R | 2006 | Nat Genet2006，38，12： | 1 |
| 10 | Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid - dependent nephrotic syndrome显示文摘 | Gbadegesin R Hinkes BV langos C | 2007 | Pediatr Nephrol2007，22，4： | 1 |
| 11 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis(IDMS)显示文摘 | GBADEGESIN R HINKES B G HOSKINS B E | 2008 | Nephrology Dialysis Transplantation2008，23，4： | 1 |
| 12 | Isolation and partial characteriza- tion of a root-specific promoter for stacking multiple traits in- to cassava(Manihot esculenta CRANTZ)显示文摘 | Gbadegesin M Beeching J | 2011 | Genetics and Molecular Research2011，10，2： | 1 |
| 13 | Role of TGF- beta I in renal parenchymal scarring following childhood urinary tract infection显示文摘 | Cotton SA Gbadegesin RA Williams S | 2002 | Kidney Int2002，61，1： | 1 |
| 14 | Voluntary counseling and testing(VCT) for human immunodeficiency virus: a study on acceptability by Nigerian Women attending antenatal clinics 显示文摘 | EE Ekanem A Gbadegesin | 2004 | African Jourual of Reproductive Health2004，8，2： | 1 |
| 15 | Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium显示文摘 | Caroline Straatmann Rose Ayoob Rasheed Gbadegesin Keisha Gibson Michelle N. Rheault Tarak Srivastava Cheryl L. Tran Debbie S. Gipson Larry A. Greenbaum William E. Smoyer V. Matti Vehaskari | 2013 | Pediatric Nephrology2013，，8： | 1 |
| 16 | On the occurrence of nematode in- duced pine wilt disease in Nigeria显示文摘 | Khan F A Gbadegesin R A | 1991 | Pakistan Journal of Nema- tology1991，，9： | 1 |
| 17 | Pathogenesis and therapy of focal segmental glomerulosclerosis : an update 显示文摘 | Gbadegesin R Lavin P Foreman J | 2011 | Pe- diatr Nephrol2011，26，7： | 1 |
| 18 | Exclusion of homozygous PLCE1 ( NPHS3 ) mutations in 69 families with idiopathic and hereditary FSGS 显示文摘 | Gbadegesin R Bartkowiak B Lavin PJ | 2009 | Pediatr Nephrel2009，24，1： | 1 |
| 19 | Mutationalanalysis of NPHS2 and WT1 in frequently relapsing andsteroid-dependent nephrotic syndrome 显示文摘 | Gbadegesin R Hinkes B Vlangos C | 2007 | Pediatr Nephrol2007，22，4： | 1 |
| 20 | Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (DMS) 显示文摘 | Gbadegesin R Hinkes BG Hoskins BE | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
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