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2篇 您的检索式：作者名="Ge Hongchuan"

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		题名	作者	年代	出处	被引量
	1	Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection.	Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu	2015	Journal of Molecular Cell Biology2015，7，6：	2
	2	A comparison of optical performance between evacuated collector tubes with flat and semicylindric absorbers显示文摘	He Zinian Ge Hongchuan Jiang Fulin	1997	Solar Energy1997，60，2：	1

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