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| 1 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | Are there clinical or serological differences between male and female patients with primary Sjogren's syndrome显示文摘 | D f az-Lopez C Geli C Corominas H | 2004 | J Rheumatol2004，31，7： | 1 |
| 3 | Early stages of infection of rapeseed petals and leaves by Sclerotinia scleroti- orum revealed by scanning electron microscopy显示文摘 | Jamaux J Gelie B Lamarque C | 1995 | Plant Pathol1995，44，： | 1 |
| 4 | Potentialof electrical resistivity tomography to detect fault zonesin limestone and argillaceous formations in the experi-mental platform of toumemire,france显示文摘 | GELIS C REVILA CUSHING M E | 2010 | Pure AppliedGeophysics2010，167，： | 1 |
| 5 | Early stages of infection of rapeseed petals and leaves by Sclerotinia sclerotiorum revealed by scanning electron microscopy显示文摘 | Jamaux I Gelie B Lamarque C | 1995 | Plant Pathology1995，44，： | 1 |
| 6 | Early stages of infection of rapeseed petals and leaves by sclerotinia sclerotiorum revealed by scanning electron microscopy显示文摘 | Jamaux L Gelie B Lamarque C | 1995 | Plant Pathology1995，44，： | 1 |
| 7 | Early stages of infection of rapeseed petals and leaves by Sclerotinia sclerotiorum revealed by scanning electron microscopy 显示文摘 | Jamaux I Gelie B Lamarque C | 1995 | Plant Pathology1995，44，： | 1 |
| 8 | Early stages of infection of rapeseed petals and leaves by sclerotinia sclerotiorum revealed by scanning electron microscopy显示文摘 | JAMAUX L GELIE B LAMARQUE C | 1995 | Plant Pathology1995，44，： | 1 |
| 9 | Moisture diffusivity in quinoa seeds:Effect of air temperature and initial moisture content of seeds显示文摘 | María C Gely Estela M Santalla | 2007 | Journal of Food Engineering2007，78，3： | 1 |
| 10 | Assessment of the skin photoproteetive capacities of an organo-mineral broad- spectrum sunblock on two exvivo skin models 显示文摘 | Gelis C Girard S Mavon A | 2003 | Photochem Photobiol2003，19，5： | 1 |
| 11 | Experimentally exploring the conformational space sampled by domain reorientation in ealmodulin显示文摘 | Bertini I Del Bianco C Gelis I | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 12 | Physical properties of quinoa seeds 显示文摘 | Vilche C Gely M Santalla E | 2003 | Biosystems Engineering2003，86，1： | 1 |
| 13 | Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR显示文摘 | BERNARD C GELY S BOURHIS JM | 2009 | FEBS Lett2009，583，7： | 1 |
| 14 | Early stages of infection of rapeseed petals and leaves by Sclerotinia sclerotiorum revealed by scanning electron microscopy显示文摘 | JAMAUX I GELIE B LAMARQUE C | | 0，，： | 1 |
| 15 | Assessment of the skin photoprotective capacities of an organo-mineral broadspectrum sunblock on two ex vivo skin models 显示文摘 | Gelis C Girard S Mavon A | 2003 | Photodermatol Photoimmunol Photamed2003，19，5： | 1 |
| 16 | Use of the Roche LightCy-cler 480 system in a routine laboratory setting for molecular diag-nosis of opportunistic viral infections: Evaluation on whole bloodspecimens and proficiency panels显示文摘 | Deback C Geli J Ait-Arkoub Z | 2009 | J Virol Methods2009，159，2： | 1 |
| 17 | Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models显示文摘 | Gelis C Girard S Mavon A Delverdier M Paillous N Vicendo P | 2003 | Photodermatol Photoimmunol Photomed2003，19，5： | 1 |
| 18 | Gene-specific promoter hypermethylation without global hypomethylation in follicular thyroid cancer显示文摘 | Lee JJ Geli J Larsson C | 2008 | Int J Oncol2008，33，4： | 1 |
| 19 | Early stages of infection of rapeseed petals and leaves by Sclerotinia sclerotiorum revealed by scanning electron microscopy显示文摘 | JAMAUX J GELIE B LAMARQUE C | 1995 | Plant Pathol1995，44，： | 1 |
| 20 | Early stages of infection of rapeseed petals and leaves by sclerotinia sclertiorum revealed by scanning electron microscopy显示文摘 | JAMAUX I GELIE B LAMARQUE C | 1995 | Plant Pathology1995，44，： | 1 |
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